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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.7 P.526-532

http://doi.org/10.1631/jzus.2007.B0526


Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines


Author(s):  MALLIKARJUNA B.P., SURESH KUMAR G.V., SASTRY B.S., NAGARAJ, MANOHARA K.P.

Affiliation(s):  Department of Medicinal Chemistry, St. Johns Pharmacy College, Bangalore-560040, Karnataka, India; more

Corresponding email(s):   gvsureshkumar@yahoo.com

Key Words:  5, 6-Bis aryl 1, 2, 4-triazines, Synthesis, Anticonvulsant activity


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MALLIKARJUNA B.P., SURESH KUMAR G.V., SASTRY B.S., NAGARAJ, MANOHARA K.P.. Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines[J]. Journal of Zhejiang University Science B, 2007, 8(7): 526-532.

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author="MALLIKARJUNA B.P., SURESH KUMAR G.V., SASTRY B.S., NAGARAJ, MANOHARA K.P.",
journal="Journal of Zhejiang University Science B",
volume="8",
number="7",
pages="526-532",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0526"
}

%0 Journal Article
%T Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines
%A MALLIKARJUNA B.P.
%A SURESH KUMAR G.V.
%A SASTRY B.S.
%A NAGARAJ
%A MANOHARA K.P.
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 7
%P 526-532
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0526

TY - JOUR
T1 - Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines
A1 - MALLIKARJUNA B.P.
A1 - SURESH KUMAR G.V.
A1 - SASTRY B.S.
A1 - NAGARAJ
A1 - MANOHARA K.P.
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 7
SP - 526
EP - 532
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0526


Abstract: 
In the present research, a series of 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5,286-Bis aryl 1%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>6-Bis aryl 1,2,4-triazines 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5a~285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5f were synthesized by condensation of various benzils 4a~4f with aminoguanidine bicarbonate and were screened in vivo, for their anticonvulsant and neurotoxicity studies. Compounds 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5a, 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5b and 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5d were found to be potent molecules of this series, when compared with the reference drugs phenytoin sodium, diazepam and lamotrigine. The structures of these compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopic data.

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