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Yong He


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Journal of Zhejiang University SCIENCE A 2020 Vol.21 No.11 P.859-875


Coaxial 3D bioprinting of organ prototyps from nutrients delivery to vascularization

Author(s):  Hamed Ramezani, Lu-yu Zhou, Lei Shao, Yong He

Affiliation(s):  The State Key Laboratory of Fluid Power and Mechatronic Systems and Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province, School of Mechanical Engineering, Zhejiang University, Hangzhou 310027, China

Corresponding email(s):   yongqin@zju.edu.cn

Key Words:  3D bioprinting, Coaxial bioprinting, Vascularization, Bioink

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Hamed Ramezani, Lu-yu Zhou, Lei Shao, Yong He. Coaxial 3D bioprinting of organ prototyps from nutrients delivery to vascularization[J]. Journal of Zhejiang University Science A, 2020, 21(11): 859-875.

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%A Hamed Ramezani
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.A2000261

T1 - Coaxial 3D bioprinting of organ prototyps from nutrients delivery to vascularization
A1 - Hamed Ramezani
A1 - Lu-yu Zhou
A1 - Lei Shao
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J0 - Journal of Zhejiang University Science A
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.A2000261

Vascular networks inside organs provide the means for metabolic exchange and adequate nutrition. Similarly, vascular or nutrient networks are needed when building tissue constructs >500 μm in vitro due to the hydrogel compact pore size of bioinks. As the hydrogel used in bioinks is rather soft, it is a great challenge to reconstruct effective vascular networks. Recently, coaxial 3D bioprinting was developed to print tissue constructs directly using hollow hydrogel fibers, which can be treated as built-in microchannels for nutrient delivery. Furthermore, vascular networks could be printed directly through coaxial 3D bioprinting. This review summarizes recent advances in coaxial bioprinting for the fabrication of complex vascularized tissue constructs including methods, the effectiveness of varying strategies, and the use of sacrificial bioink. The limitations and challenges of coaxial 3D bioprinting are also summarized.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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