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CLC number: R574.62

On-line Access: 2015-03-05

Received: 2014-07-07

Revision Accepted: 2014-12-03

Crosschecked: 2015-02-17

Cited: 6

Clicked: 3227

Citations:  Bibtex RefMan EndNote GB/T7714


Joshua J. Malago


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.3 P.224-234


Intraperitoneal administration of butyrate prevents the severity of acetic acid colitis in rats

Author(s):  Joshua J. Malago, Catherine L. Sangu

Affiliation(s):  Department of Pathology, Faculty of Veterinary Medicine, Sokoine University of Agriculture, P.O. Box 3203, Morogoro, Tanzania; more

Corresponding email(s):   malagojj@yahoo.com

Key Words:  Butyrate, Oral administration, Intraperitoneal administration, Intrarectal administration, Acetic acid, Ulcerative colitis

Joshua J. Malago, Catherine L. Sangu. Intraperitoneal administration of butyrate prevents the severity of acetic acid colitis in rats[J]. Journal of Zhejiang University Science B, 2015, 16(3): 224-234.

@article{title="Intraperitoneal administration of butyrate prevents the severity of acetic acid colitis in rats",
author="Joshua J. Malago, Catherine L. Sangu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Intraperitoneal administration of butyrate prevents the severity of acetic acid colitis in rats
%A Joshua J. Malago
%A Catherine L. Sangu
%J Journal of Zhejiang University SCIENCE B
%V 16
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%P 224-234
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400191

T1 - Intraperitoneal administration of butyrate prevents the severity of acetic acid colitis in rats
A1 - Joshua J. Malago
A1 - Catherine L. Sangu
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 3
SP - 224
EP - 234
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400191

Intrarectal infusion of butyrate improves colorectal disorders including ulcerative colitis (UC). However, it is not established whether systemically administered butyrate benefits such patients. The current study aimed at exploring and comparing the potential of intraperitoneally, intrarectally, and orally administered butyrate against acetic acid (AA)-induced UC in rats. intrarectal administration of 2 ml of 50% AA was done after or without prior treatment of rats for 7 consecutive days with 100 mg/kg sodium butyrate (SB) intraperitoneally, intrarectally, or orally. Rats were sacrificed after 48 h of AA-treatment. Subsequently, colon sections were processed routinely for histopathological examination. We clinically observed diarrhea, loose stools, and hemoccult-positive stools, and histologically, epithelial loss and ulceration, crypt damage, goblet cell depletion, hemorrhage, and mucosal infiltration of inflammatory cells. The changes were significantly reduced by intraperitoneal, intrarectal, or oral butyrate, with intraperitoneal butyrate exhibiting the highest potency. It is concluded that intraperitoneal administration of butyrate abrogates the lesions of AA-induced UC and its potency surpasses that of intrarectal or oral butyrate.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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