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CLC number: R512.6+2; R943; R978.7
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Received: 2008-02-16
Revision Accepted: 2008-04-24
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Cited: 9
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Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy
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Xing-guo ZHANG, Jing MIAO, Min-wei LI, Sai-ping JIANG, Fu-qiang HU, Yong-zhong DU. Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy[J]. Journal of Zhejiang University Science B, 2008, 9(6): 506-510.
@article{title="Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy",
author="Xing-guo ZHANG, Jing MIAO, Min-wei LI, Sai-ping JIANG, Fu-qiang HU, Yong-zhong DU",
journal="Journal of Zhejiang University Science B",
volume="9",
number="6",
pages="506-510",
year="2008",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820047"
}
%0 Journal Article
%T Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy
%A Xing-guo ZHANG
%A Jing MIAO
%A Min-wei LI
%A Sai-ping JIANG
%A Fu-qiang HU
%A Yong-zhong DU
%J Journal of Zhejiang University SCIENCE B
%V 9
%N 6
%P 506-510
%@ 1673-1581
%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820047
TY - JOUR
T1 - Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy
A1 - Xing-guo ZHANG
A1 - Jing MIAO
A1 - Min-wei LI
A1 - Sai-ping JIANG
A1 - Fu-qiang HU
A1 - Yong-zhong DU
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 6
SP - 506
EP - 510
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820047
Abstract: Herein, solid lipid nanoparticles (SLN) were proposed as a new drug delivery system for adefovir dipivoxil (ADV). The octadecylamine-fluorescein isothiocynate (ODA-FITC) was synthesized and used as a fluorescence maker to be incorporated into SLN to investigate the time-dependent cellular uptake of SLN by HepG2.2.15. The SLN of monostearin with ODA-FITC or ADV were prepared by solvent diffusion method in an aqueous system. About 15 wt% drug entrapment efficiency (EE) and 3 wt% drug loading (DL) could be reached in SLN loading ADV. Comparing with free ADV, the inhibitory effects of ADV loaded in SLN on hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA levels in vitro were significantly enhanced.
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