CLC number: R512.6+2; R943; R978.7
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
Cited: 9
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Xing-guo ZHANG, Jing MIAO, Min-wei LI, Sai-ping JIANG, Fu-qiang HU, Yong-zhong DU. Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy[J]. Journal of Zhejiang University Science B, 2008, 9(6): 506-510.
@article{title="Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy",
author="Xing-guo ZHANG, Jing MIAO, Min-wei LI, Sai-ping JIANG, Fu-qiang HU, Yong-zhong DU",
journal="Journal of Zhejiang University Science B",
volume="9",
number="6",
pages="506-510",
year="2008",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820047"
}
%0 Journal Article
%T Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy
%A Xing-guo ZHANG
%A Jing MIAO
%A Min-wei LI
%A Sai-ping JIANG
%A Fu-qiang HU
%A Yong-zhong DU
%J Journal of Zhejiang University SCIENCE B
%V 9
%N 6
%P 506-510
%@ 1673-1581
%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820047
TY - JOUR
T1 - Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy
A1 - Xing-guo ZHANG
A1 - Jing MIAO
A1 - Min-wei LI
A1 - Sai-ping JIANG
A1 - Fu-qiang HU
A1 - Yong-zhong DU
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 6
SP - 506
EP - 510
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820047
Abstract: Herein, solid lipid nanoparticles (SLN) were proposed as a new drug delivery system for adefovir dipivoxil (ADV). The octadecylamine-fluorescein isothiocynate (ODA-FITC) was synthesized and used as a fluorescence maker to be incorporated into SLN to investigate the time-dependent cellular uptake of SLN by HepG2.2.15. The SLN of monostearin with ODA-FITC or ADV were prepared by solvent diffusion method in an aqueous system. About 15 wt% drug entrapment efficiency (EE) and 3 wt% drug loading (DL) could be reached in SLN loading ADV. Comparing with free ADV, the inhibitory effects of ADV loaded in SLN on hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA levels in vitro were significantly enhanced.
[1] Dai, C.Y., Chuang, W.L., Hsieh, M.Y., Lee, L.P., Huang, J.F., Hou, N.J., Lin, Z.Y., Chen, S.C., Hsieh, M.Y., Wang, L.Y., et al., 2007. Adefovir dipivoxil treatment of lamivudine-resistant chronic hepatitis B. Antiviral. Res., 75(2):146-151.
[2] Hadziyannis, S.J., Tassopoulos, N.C., Jenny Heathcote, E., Chang, T.T., Kitis, G., Rizzetto, M., Marcellin, P., Lim, S.G., Goodman, Z., Wulfsohn, M.S., et al., 2003. Adefovir dipivoxil for the treatment of hepatitis B e antigen-negative chronic hepatitis B. N. Engl. J. Med., 348(9):800-807.
[3] Hu, F.Q., Jiang, S.P., Du, Y.Z., Yuan, H., Ye, Y.Q., Zeng, S., 2005. Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system. Colloid and Surfaces B-Biointerfaces, 45(3-4):167-173.
[4] Iyer, R.P., Padmanabhan, S., Zhang, G.R., Morrey, J.D., Korba, B.E., 2005. Nucleotide analogs as novel anti-hepatitis B virus agents. Curr. Opin. Pharmacol., 5(5):520-528.
[5] Jiang, J.T., Xu, N., Zhang, X.Y., Wu, C.P., 2007. Lipids changes in liver cancer. J. Zhejiang Univ. Sci. B, 8(6):398-409.
[6] Lai, C.L., Ratziu, V., Yuen, M.F., Poynard, T., 2003. Viral hepatitis B. Lancet, 362(9401):2089-2094.
[7] Marcellin, P., Chang, T.T., Lim, S.G., Tong, M.J., Sievert, W., Shiffman, M.L., Jeffers, L., Goodman, Z., Wulfsohn, M.S., Xiong, S., et al., 2003. Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B. N. Engl. J. Med., 348(9):808-816.
[8] Marengo, E., Cavalli, R., Caputo, O., Rodriguez, L., Gasco, M., 2000. Scale-up of the preparation process of solid lipid nanospheres. Int. J. Pharm., 205(1-2):3-13.
[9] Mehnert, W., Mäder, K., 2001. Solid lipid nanoparticles: production, characterization and applications. Adv. Drug Deliv. Rev., 47(2-3):165-196.
[10] Müller, R., Mäder, K., Gohla, S., 2000. Solid lipid nanoparticles (SLN) for controlled drug delivery—a review of the state of the art. Eur. J. Pharm. Biopharm., 50(1):161-177.
[11] Perrillo, R., Schiff, E., Yoshida, E., Statler, A., Hirsch, K., Wright, T., Gutfreund, K., Lamy, P., Murray, A., 2000. Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutants. Hepatology, 32(1):129-134.
[12] Perrillo, R., Hann, H.W., Mutimer, D., Willems, B., Leung, N., Lee, W.M., Moorat, A., Gardner, S., Woessner, M., Bourne, E., Brosgart, C.L., Schiff, E., 2004. Adefovir dipivoxil added to ongoing lamivudine in chronic hepatitis B with YMDD mutant hepatitis B virus. Gastroenterology, 126(1):81-90.
[13] Raney, A.K., Hamatake, R.K., Hong, Z., 2003. Agents in clinical development for the treatment of chronic hepatitis B. Expert Opin. Investig. Drugs, 12(8):1281-1295.
[14] Westland, C.E., Yang, H., Delaney IV, W.E., Wulfsohn, M., Lama, N., Gibbs, C.S., Miller, M.D., Fry, J., Brosgart, C.L., Schiff, E.R., Xiong, S., 2005. Activity of adefovir dipivoxil against all patterns of lamivudine-resistant hepatitis B viruses in patients. J. Viral Hepat., 12(1):67-73.
[15] Yuan, H., Chen, J., Du, Y.Z., Hu, F.Q., Zeng, S., 2007. Studies on oral absorption of stearic acid SLN by a novel fluorometric method. Colloid and Surfaces B-Biointerfaces, 58(2):157-164.
[16] Yuan, H., Miao, J., Du, Y.Z., You, J., Hu, F.Q., Zeng, S., 2008. Cellular uptake of solid lipid nanoparticles and cytotoxicity of encapsulated paclitaxel in A549 cancer cells. Int. J. Pharm., 348(1-2):137-145.
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