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CLC number: R459.9

On-line Access: 2011-11-30

Received: 2010-11-22

Revision Accepted: 2011-10-26

Crosschecked: 2011-11-10

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.12 P.1034-1040

http://doi.org/10.1631/jzus.B1000406


Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis


Author(s):  Ling Wang, Yuan Li, Qin Ma, Yong Liu, Yuan-yi Rui, Ping Xue, Zong-guang Zhou

Affiliation(s):  Institute of Digestive Surgery and Department of Colorectal Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China

Corresponding email(s):   liyuanletters@163.com

Key Words:  Acute pancreatitis, Cytokine, Chaiqin Chengqi Decoction (CQCQD)


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Ling Wang, Yuan Li, Qin Ma, Yong Liu, Yuan-yi Rui, Ping Xue, Zong-guang Zhou. Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis[J]. Journal of Zhejiang University Science B, 2011, 12(12): 1034-1040.

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author="Ling Wang, Yuan Li, Qin Ma, Yong Liu, Yuan-yi Rui, Ping Xue, Zong-guang Zhou",
journal="Journal of Zhejiang University Science B",
volume="12",
number="12",
pages="1034-1040",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000406"
}

%0 Journal Article
%T Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis
%A Ling Wang
%A Yuan Li
%A Qin Ma
%A Yong Liu
%A Yuan-yi Rui
%A Ping Xue
%A Zong-guang Zhou
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 12
%P 1034-1040
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000406

TY - JOUR
T1 - Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis
A1 - Ling Wang
A1 - Yuan Li
A1 - Qin Ma
A1 - Yong Liu
A1 - Yuan-yi Rui
A1 - Ping Xue
A1 - Zong-guang Zhou
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 12
SP - 1034
EP - 1040
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000406


Abstract: 
Objective: In this paper, we investigated the effect of the traditional Chinese medicine chaiqin Chengqi Decoction (CQCQD) on serum cytokines in acute pancreatitis (AP) patients. Methods: Peripheral blood samples from 107 AP patients were collected within the first 48 h of AP onset and on the 10th day of CQCQD treatment. Control samples were collected from 20 healthy individuals. Serum proinflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), and anti-inflammatory cytokines IL-10 and IL-1β receptor antagonist (IL-1ra) were examined using the Luminex 100 system. Results: Within the first 48 h of AP onset, IL-6 and IL-1ra levels in severe AP (SAP) patients were significantly higher than those in mild AP (MAP) patients, but IL-10 levels in SAP patients were significantly lower than those in MAP patients. Proinflammatory cytokine IL-6 was significantly decreased after CQCQD treatment (P<0.05), especially in SAP patients (n=25 of 36, P<0.05). The hospitalization time of SAP patients was shortened significantly when serum IL-6 decreased after CQCQD treatment (P<0.05). Conclusions: CQCQD decreased proinflammatory cytokine IL-6 levels in AP patients.

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