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CLC number: R54

On-line Access: 2010-08-05

Received: 2010-06-17

Revision Accepted: 2010-07-05

Crosschecked: 2010-07-07

Cited: 2

Clicked: 4528

Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.8 P.548-552

http://doi.org/10.1631/jzus.B1001004


Elevated high sensitive C-reactive protein and apelin levels after percutaneous coronary intervention and drug-eluting stent implantation


Author(s):  Xin Du, Jun-ping Kang, Jia-hui Wu, Qiang Lv, Chao-shu Tang, Chang-sheng Ma

Affiliation(s):  Cardiovascular Division, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China, Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing 100083, China

Corresponding email(s):   duxinheart@sina.com, chshma@vip.sina.com

Key Words:  High sensitive C-reactive protein (hs-CRP), Apelin, Percutaneous coronary intervention (PCI)


Xin Du, Jun-ping Kang, Jia-hui Wu, Qiang Lv, Chao-shu Tang, Chang-sheng Ma. Elevated high sensitive C-reactive protein and apelin levels after percutaneous coronary intervention and drug-eluting stent implantation[J]. Journal of Zhejiang University Science B, 2010, 11(8): 548-552.

@article{title="Elevated high sensitive C-reactive protein and apelin levels after percutaneous coronary intervention and drug-eluting stent implantation",
author="Xin Du, Jun-ping Kang, Jia-hui Wu, Qiang Lv, Chao-shu Tang, Chang-sheng Ma",
journal="Journal of Zhejiang University Science B",
volume="11",
number="8",
pages="548-552",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1001004"
}

%0 Journal Article
%T Elevated high sensitive C-reactive protein and apelin levels after percutaneous coronary intervention and drug-eluting stent implantation
%A Xin Du
%A Jun-ping Kang
%A Jia-hui Wu
%A Qiang Lv
%A Chao-shu Tang
%A Chang-sheng Ma
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 8
%P 548-552
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1001004

TY - JOUR
T1 - Elevated high sensitive C-reactive protein and apelin levels after percutaneous coronary intervention and drug-eluting stent implantation
A1 - Xin Du
A1 - Jun-ping Kang
A1 - Jia-hui Wu
A1 - Qiang Lv
A1 - Chao-shu Tang
A1 - Chang-sheng Ma
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 8
SP - 548
EP - 552
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1001004


Abstract: 
Objective: percutaneous coronary intervention (PCI) triggers an acute inflammatory response, while sirolimus is known to have anti-inflammatory properties; the inflammatory system response to PCI after sirolimus-eluting stent placement remains unclear. The purpose of this study is to determine the changes in high sensitive C-reactive protein (hs-CRP) and apelin after PCI procedure and drug-eluting stent implantation in patients with and without reduced left ventricular systolic function. Methods: Forty-eight consecutive patients undergoing PCI at the Beijing Anzhen Hospital between July and September 2006 were recruited. Sirolimus-eluting stents were employed in all patients. Blood samples were drawn immediately before and 24 h after the procedure. Plasma hs-CRP and apelin levels were determined by enzyme immunoassay. Results: Paired t-test revealed a significant increase in both hs-CRP and apelin post-procedure (P=0.006 and P<0.0001, respectively). Patients with reduced left ventricular ejection fraction (LVEF) had significantly lower baseline apelin levels compared to those with normal ventricular function [(46.8±10.8) vs. (72.0±8.4) pg/ml, P<0.001]. However, apelin increased to a level similar to the level of those with normal left ventricular systolic function 24 h after the PCI procedure [(86.7±11.6) vs. (85.1±6.1) pg/ml, P=0.72]. Conclusions: hs-CRP and apelin levels increased after PCI and sirolimus-eluting stent implantation. Patients with impaired left ventricular systolic function had significantly lower baseline apelin levels, which increased significantly after PCI.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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