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CLC number: R541

On-line Access: 2013-06-04

Received: 2012-10-28

Revision Accepted: 2013-02-20

Crosschecked: 2013-05-17

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.6 P.505-510

http://doi.org/10.1631/jzus.B1200293


β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation


Author(s):  Xiao-jing Zhao, Zhuo Pen, Ping Li, Er-xiu Chen, Jian Liu, Yan-xia Gao, Yun-xia Ren, Li-jun Li

Affiliation(s):  Department of Emergency Medicine, the Second Affiliated Hospital of Medical College, Xian Jiaotong University, Xian 710004, China; more

Corresponding email(s):   zxj47@aliyun.com

Key Words:  β, -receptor blocker, Cardiopulmonary resuscitation, Return of spontaneous circulation, Epinephrine, Chemical examination


Xiao-jing Zhao, Zhuo Pen, Ping Li, Er-xiu Chen, Jian Liu, Yan-xia Gao, Yun-xia Ren, Li-jun Li. β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation[J]. Journal of Zhejiang University Science B, 2013, 14(6): 505-510.

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author="Xiao-jing Zhao, Zhuo Pen, Ping Li, Er-xiu Chen, Jian Liu, Yan-xia Gao, Yun-xia Ren, Li-jun Li",
journal="Journal of Zhejiang University Science B",
volume="14",
number="6",
pages="505-510",
year="2013",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1200293"
}

%0 Journal Article
%T β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation
%A Xiao-jing Zhao
%A Zhuo Pen
%A Ping Li
%A Er-xiu Chen
%A Jian Liu
%A Yan-xia Gao
%A Yun-xia Ren
%A Li-jun Li
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 6
%P 505-510
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200293

TY - JOUR
T1 - β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation
A1 - Xiao-jing Zhao
A1 - Zhuo Pen
A1 - Ping Li
A1 - Er-xiu Chen
A1 - Jian Liu
A1 - Yan-xia Gao
A1 - Yun-xia Ren
A1 - Li-jun Li
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 6
SP - 505
EP - 510
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200293


Abstract: 
Objective: We investigated the influence of β;-receptor blocker metoprolol on return of spontaneous circulation (ROSC) during cardiopulmonary resuscitation (CPR) in rats with induced myocardial infarction (MI). Methods: Male Sprague-Dawley rats were randomly divided into three groups: the sham-operated group, the MI group without metoprolol, which was fed the vehicle, and the MI+metoprolol group receiving intragastric metoprolol. Each group was further divided randomly into three subgroups, depending on the dosage of epinephrine administered during subsequent CPR applied after the induction of asphyxial cardiac arrest. Results: The ROSC rate was significantly decreased in the low dose subgroup of MI group, unchanged in the medium dose subgroup of MI group, and significantly decreased in the high dose subgroup of MI group, compared with the same dose subgroup of sham-operated group. MI+metoprolol group had a lower ROSC rate than MI group in the medium dose subgroup, and a higher ROSC rate than MI group in the high dose subgroup. There was no difference in blood K+ values of successful rats between MI group and MI+metoprolol group. The rats with successful CPR had lower blood K+ values than rats with unsuccessful CPR in each of the three treatment groups. Conclusions: Metoprolol administered to MI rats over a long period significantly improved ROSC rates under an appropriate dose of epinephrine during CPR. An increasing high blood K+ value would attenuate the rate of a successful CPR.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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