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CLC number: R541

On-line Access: 2013-06-04

Received: 2012-10-28

Revision Accepted: 2013-02-20

Crosschecked: 2013-05-17

Cited: 1

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Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.6 P.505-510

http://doi.org/10.1631/jzus.B1200293


β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation


Author(s):  Xiao-jing Zhao, Zhuo Pen, Ping Li, Er-xiu Chen, Jian Liu, Yan-xia Gao, Yun-xia Ren, Li-jun Li

Affiliation(s):  Department of Emergency Medicine, the Second Affiliated Hospital of Medical College, Xi’an Jiaotong University, Xi’an 710004, China; more

Corresponding email(s):   zxj47@aliyun.com

Key Words:  β, -receptor blocker, Cardiopulmonary resuscitation, Return of spontaneous circulation, Epinephrine, Chemical examination


Xiao-jing Zhao, Zhuo Pen, Ping Li, Er-xiu Chen, Jian Liu, Yan-xia Gao, Yun-xia Ren, Li-jun Li. β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation[J]. Journal of Zhejiang University Science B, 2013, 14(6): 505-510.

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author="Xiao-jing Zhao, Zhuo Pen, Ping Li, Er-xiu Chen, Jian Liu, Yan-xia Gao, Yun-xia Ren, Li-jun Li",
journal="Journal of Zhejiang University Science B",
volume="14",
number="6",
pages="505-510",
year="2013",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1200293"
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%0 Journal Article
%T β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation
%A Xiao-jing Zhao
%A Zhuo Pen
%A Ping Li
%A Er-xiu Chen
%A Jian Liu
%A Yan-xia Gao
%A Yun-xia Ren
%A Li-jun Li
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 6
%P 505-510
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200293

TY - JOUR
T1 - β-receptor blocker influences return of spontaneous circulation and chemical examination in rats during cardiopulmonary resuscitation
A1 - Xiao-jing Zhao
A1 - Zhuo Pen
A1 - Ping Li
A1 - Er-xiu Chen
A1 - Jian Liu
A1 - Yan-xia Gao
A1 - Yun-xia Ren
A1 - Li-jun Li
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 6
SP - 505
EP - 510
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200293


Abstract: 
Objective: We investigated the influence of β;-receptor blocker metoprolol on return of spontaneous circulation (ROSC) during cardiopulmonary resuscitation (CPR) in rats with induced myocardial infarction (MI). Methods: Male Sprague-Dawley rats were randomly divided into three groups: the sham-operated group, the MI group without metoprolol, which was fed the vehicle, and the MI+metoprolol group receiving intragastric metoprolol. Each group was further divided randomly into three subgroups, depending on the dosage of epinephrine administered during subsequent CPR applied after the induction of asphyxial cardiac arrest. Results: The ROSC rate was significantly decreased in the low dose subgroup of MI group, unchanged in the medium dose subgroup of MI group, and significantly decreased in the high dose subgroup of MI group, compared with the same dose subgroup of sham-operated group. MI+metoprolol group had a lower ROSC rate than MI group in the medium dose subgroup, and a higher ROSC rate than MI group in the high dose subgroup. There was no difference in blood K+ values of successful rats between MI group and MI+metoprolol group. The rats with successful CPR had lower blood K+ values than rats with unsuccessful CPR in each of the three treatment groups. Conclusions: Metoprolol administered to MI rats over a long period significantly improved ROSC rates under an appropriate dose of epinephrine during CPR. An increasing high blood K+ value would attenuate the rate of a successful CPR.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]ACCESS Investigators, 2011. Management of acute coronary syndromes in developing countries: acute coronary events—a multinational survey of current management strategies. Am. Heart. J., 162(5):852-859.

[2]Attaran, R.R., Ewy, G.A., 2010. Epinephrine in resuscitation: curse or cure? Future Cardiol., 6(4):473-482.

[3]Berg, R.A., Otto, C.W., Kern, K.B., Hilwig, R.W., Sanders, A.B., Henry, C.P., Ewy, G.A., 1996. A randomized, blinded trial of high-dose epinephrine versus standard-dose epinephrine in a swine model of pediatric asphyxial cardiac arrest. Crit. Care Med., 24(10):1695-1700.

[4]Emergency Cardiac Care Committee and Subcommittees, American Heart Association, 1992. Guidelines for cardiopulmonary resuscitation and emergency cardiac care. Part IX. Ensuring effectiveness of communitywide emergency cardiac care. JAMA, 268(16):2289-2295.

[5]Geddes, L.A., Roeder, R.A., Rundell, A.E., Otlewski, M.P., Kemeny, A.E., Lottes, A.E., 2006. The natural biochemical changes during ventricular fibrillation with cardiopulmonary resuscitation and the onset of postdefibrillation pulseless electrical activity. Am. J. Emer. Med., 24(5):577-581.

[6]Gottlieb, S.S., McCarter, R.J., Vogel, R.A., 1998. Effect of β-blockade on mortality among high-risk and low-risk patients after myocardial infarction. N. Engl. J. Med., 339(8):489-497.

[7]Hendrickx, H.H., Rao, G.R., Safar, P., Gisvold, S.E., 1984. Asphyxia, cardiac arrest andresuscitation in rats. Resuscitation, 12(2):97-116.

[8]Holmes, H.R., Babbs, C.F., Voorhees, W.D., deGaravilla, B., 1980. Influence of adrenergic drugs upon vital organ perfusion during CPR. Crit. Care Med., 8(3):137-140.

[9]Huang, L., Weil, M.H., Cammarata, G., Sun, S., Tang, W., 2004. Nonselective β-blocking agent improves the outcome of cardiopulmonary resuscitation in a rat model. Crit. Care Med., 32(S9):S378-S380.

[10]Huang, L., Sun, S., Fang, X., Tang, W., Weil, M.H., 2006. Simultaneous blockade of α1- and β-actions of epinephrine during cardiopulmonary resuscitation. Crit. Care Med., 34(S12):S483-S485.

[11]Jeung, K.W., Ryu, H.H., Song, K.H., Lee, B.K., Lee, H.Y., Heo, T., Min, Y.I., 2011. Variable effects of high-dose adrenaline relative to standard-dose adrenaline on resuscitation outcomes according to cardiac arrest duration. Resuscitation, 82(7):932-936.

[12]Kurita, A., Taniguchi, T., Yamamoto, K., 2010. The effects of carvedilol administration on cardiopulmonary resuscitation in a rat model of cardiac arrest induced by airway obstruction. Anesth. Analg., 111(5):1207-1210.

[13]Lei, L., Zhou, R., Zheng, W., Christensen, L.P., Weiss, R.M., Tomanek, R.J., 2004. Bradycardia induces angiogenesis, increases coronary reserve, and preserves function of the postinfarcted heart. Circulation, 110:796-802.

[14]Liakopoulos, O.J., Allen, B.S., Buckberg, G.D., Hristov, N., Tan, Z., Villablanca, J.P., Trummer, G., 2010. Resuscitation after prolonged cardiac arrest: role of cardiopulmonary bypass and systemic hyperkalemia. Ann. Thorac. Surg., 89(6):1972-1979.

[15]Lindner, K.H., Ahnefeld, F.W., Bowdler, I.M., 1988. The effect of epinephrine on hemodynamics, acid-base status and potassium during spontaneous circulation and cardiopulmonary resuscitation. Resuscitation, 16(4):251-261.

[16]Lisachenko, G.V., Ivanova, N.A., 1999. Electrolyte disorders in the postresuscitation period after acute myocardial infarct. Anesteziol. Reanimatol., (1):35-36 (in Russian).

[17]Metra, M., Nodari, S., D′Aloia, A., Muneretto, C., Robertson, A.D., Bristow, M.R., Dei Cas, L., 2002. β-blocker therapy influences the hemodynamic response to inotropic agents in patients with heart failure: a randomized comparison of dobutamine and enoximone before and after chronic treatment with metoprolol or carvedilol. J. Am. Coll. Cardiol., 40(7):1248-1258.

[18]Neumar, R.W., Otto, C.W., Link, M.S., Kronick, S.L., Shuster, M., Callaway, C.W., Kudenchuk, P.J., Ornato, J.P., McNally, B., Silvers, S.M., et al., 2010. Part 8: adult advanced cardiovascular life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation, 122(18 Suppl. 3):S729-S767.

[19]Norwegian Multicenter Study Group, 1981. Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. N. Engl. J. Med., 304:801-807.

[20]Ristagno, G., Tang, W., Huang, L., Fymat, A., Chang, Y.T., Sun, S., Castillo, C., Weil, M.H., 2009. Epinephrine reduces cerebral perfusion during cardiopulmonary resuscitation. Crit. Care Med., 37(4):1408-1415.

[21]Sun, T., Li, Z.Z., Shen, L.H., Chen, H., Li, H.W., Tang, C.S., 2008. Effects of β-adrenergic receptor blockers on cardiac fibrosis during heart failure after myocardial infarction in rats. Chin. Circ. J., 23(3):217-220 (in Chinese).

[22]Tran, H.A., 2005. Extreme hyperkalemia. South Med. J., 98(7):729-732.

[23]Wang, T., Wan, Z., Fu, Y., Fang, X.S., Huang, Z.T., 2008. A rat model of congestive heart failure following myocardial infarction. J. Clin. Rehab. Tissue Eng. Res., 12(37):7318-7321 (in Chinese).

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