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CLC number: R91

On-line Access: 2014-01-04

Received: 2013-05-15

Revision Accepted: 2013-09-11

Crosschecked: 2013-12-24

Cited: 6

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Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2014 Vol.15 No.1 P.84-91


Comparative pharmacokinetics of borneol in cerebral ischemia-reperfusion and sham-operated rats*

Author(s):  Pan Xu, Ying Li, Shou-ying Du, Yang Lu, Jie Bai, Qing-li Guo

Affiliation(s):  . Department of Industrial Pharmacy, School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China

Corresponding email(s):   dushouying@263.net

Key Words:  Borneol, Pharmacokinetics, Cerebral ischemia-reperfusion, Xingnaojing

Pan Xu, Ying Li, Shou-ying Du, Yang Lu, Jie Bai, Qing-li Guo. Comparative pharmacokinetics of borneol in cerebral ischemia-reperfusion and sham-operated rats[J]. Journal of Zhejiang University Science B, 2014, 15(1): 84-91.

@article{title="Comparative pharmacokinetics of borneol in cerebral ischemia-reperfusion and sham-operated rats",
author="Pan Xu, Ying Li, Shou-ying Du, Yang Lu, Jie Bai, Qing-li Guo",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Comparative pharmacokinetics of borneol in cerebral ischemia-reperfusion and sham-operated rats
%A Pan Xu
%A Ying Li
%A Shou-ying Du
%A Yang Lu
%A Jie Bai
%A Qing-li Guo
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 1
%P 84-91
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300141

T1 - Comparative pharmacokinetics of borneol in cerebral ischemia-reperfusion and sham-operated rats
A1 - Pan Xu
A1 - Ying Li
A1 - Shou-ying Du
A1 - Yang Lu
A1 - Jie Bai
A1 - Qing-li Guo
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 1
SP - 84
EP - 91
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300141

Objective: This study was designed to investigate the pharmacokinetics of borneol in the pathological conditions of stroke and evaluate the pharmacokinetic differences of borneol caused by stroke after oral administration of borneol and xingnaojing (XNJ). Methods: The rats were divided into two groups, ischemia-reperfusion (IR) and sham-operated (SO) rats. Each group contained two subgroups: pure borneol and XNJ subgroups. After administration with the same dosages of borneol 162.0 mg/kg, plasma samples were collected. The cerebral ischemia-reperfusion model was created by reversible middle cerebral artery occlusion (MCAO). The blood samples were collected punctually after oral administration and a specific gas chromatographic system-flame ionization detector (GC-FID) method was developed and employed to determine the level of borneol in the plasma. The pharmacokinetic parameters were analyzed using non-compartmental methods with Kinetica. Results: After administration of borneol, the maximum plasma concentration (C max) and area under the curve (AUC) values in stroke rats significantly increased by 302% and 275%, respectively, compared with the SO rats, and the same phenomenon appeared after administration of XNJ. In the rats with the same physiological conditions, the C max and AUC had higher values in the borneol subgroup (P<0.05). Conclusions: These results suggest that the pathological damages of ischemia-reperfusion have a significant impact on the pharmacokinetic traits of borneol and that there are some components in XNJ inhibiting the absorption of borneol.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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