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On-line Access: 2011-02-04

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.2 P.143-148

http://doi.org/10.1631/jzus.B1000121


Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration


Author(s):  Yang Lu, Shou-ying Du, Xiao-lan Chen, Qing Wu, Xiao Song, Bing Xu, Yong-song Zhai

Affiliation(s):  Department of Industrial Pharmacy, School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China; more

Corresponding email(s):   dushouying@263.net

Key Words:  Geniposide, Natural borneol, Intranasal administration, Intravenous administration, Pharmacokinetics


Yang Lu, Shou-ying Du, Xiao-lan Chen, Qing Wu, Xiao Song, Bing Xu, Yong-song Zhai. Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration[J]. Journal of Zhejiang University Science B, 2011, 12(2): 143-148.

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author="Yang Lu, Shou-ying Du, Xiao-lan Chen, Qing Wu, Xiao Song, Bing Xu, Yong-song Zhai",
journal="Journal of Zhejiang University Science B",
volume="12",
number="2",
pages="143-148",
year="2011",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000121"
}

%0 Journal Article
%T Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration
%A Yang Lu
%A Shou-ying Du
%A Xiao-lan Chen
%A Qing Wu
%A Xiao Song
%A Bing Xu
%A Yong-song Zhai
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 2
%P 143-148
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000121

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T1 - Enhancing effect of natural borneol on the absorption of geniposide in rat via intranasal administration
A1 - Yang Lu
A1 - Shou-ying Du
A1 - Xiao-lan Chen
A1 - Qing Wu
A1 - Xiao Song
A1 - Bing Xu
A1 - Yong-song Zhai
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 2
SP - 143
EP - 148
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000121


Abstract: 
Both geniposide (Ge) and natural borneol (NB) are bioactive substances derived from traditional Chinese herbs. The effect of NB on the pharmacokinetics of Ge in rat via intranasal administration was investigated. The concentrations of Ge in plasma were determined by reversed-phase high-performance liquid chromatography (HPLC) after intranasal administration of Ge (4 mg/kg) alone and combined with different doses (0.08, 0.8, and 8 mg/kg) of NB. The intravenous administration was given as a reference (4 mg/kg of Ge and 8 mg/kg of NB). Compared with the intravenous administration, the absolute bioavailability of Ge was 76.14% through intranasal administration combined with NB. Compared with the intranasal administration of Ge alone, Ge could be absorbed rapidly in the nasal cavity combined with NB; the peak time of Ge in the plasma became shorter (3–5 min vs. 40 min); the peak concentration became higher (1.32–4.25 μg/ml vs. 0.67 μg/ml); and, the relative bioavailability of Ge combined with NB was 90.3%–237.8%. The enhancing effect was attenuated as the dose of NB decreased. The results indicated that NB can accelerate the absorption of Ge dose-dependently in the nasal cavity.

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