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CLC number: R593.2

On-line Access: 2016-05-04

Received: 2015-11-11

Revision Accepted: 2016-01-17

Crosschecked: 2016-04-15

Cited: 4

Clicked: 5580

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Yi-wu Zheng

http://orcid.org/0000-0002-2898-7842

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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.5 P.399-404

http://doi.org/10.1631/jzus.B1500279


High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China


Author(s):  Guo-dong Hao, Yi-wu Zheng, Zhi-xiang Wang, Xing-ai Kong, Zhi-jing Song, Xu-xin Lai, Michael D. Spangfort

Affiliation(s):  Department of Allergy, Tangshan Gongren Hospital, Tangshan 063000, China; more

Corresponding email(s):   Yiwu.Zheng@alk.net

Key Words:  Apple, Birch, Cross-reaction, Pollen-food allergy, Soy, Specific immunoglobulin E (IgE)


Guo-dong Hao, Yi-wu Zheng, Zhi-xiang Wang, Xing-ai Kong, Zhi-jing Song, Xu-xin Lai, Michael D. Spangfort. High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China[J]. Journal of Zhejiang University Science B, 2016, 17(5): 399-404.

@article{title="High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China",
author="Guo-dong Hao, Yi-wu Zheng, Zhi-xiang Wang, Xing-ai Kong, Zhi-jing Song, Xu-xin Lai, Michael D. Spangfort",
journal="Journal of Zhejiang University Science B",
volume="17",
number="5",
pages="399-404",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1500279"
}

%0 Journal Article
%T High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China
%A Guo-dong Hao
%A Yi-wu Zheng
%A Zhi-xiang Wang
%A Xing-ai Kong
%A Zhi-jing Song
%A Xu-xin Lai
%A Michael D. Spangfort
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 5
%P 399-404
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500279

TY - JOUR
T1 - High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China
A1 - Guo-dong Hao
A1 - Yi-wu Zheng
A1 - Zhi-xiang Wang
A1 - Xing-ai Kong
A1 - Zhi-jing Song
A1 - Xu-xin Lai
A1 - Michael D. Spangfort
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 5
SP - 399
EP - 404
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500279


Abstract: 
Background: birch pollen sensitization and associated pollen-food syndrome among Chinese allergic patients have not been investigated. Methods: Sera from 203 allergic patients from the northern part of China and collected during February to July 2014 were investigated. specific immunoglobulin E (IgE) against birch pollen extract Bet v and major birch pollen allergen Bet v 1 were measured using the ADVIA Centaur. The presence of major apple allergen Mal d 1 and soy bean allergen Gly m 4 specific IgE was measured by ImmunoCAP 100. Results: Among the 203 sera, 34 sera (16.7%) had specific IgE to Bet v and of these, 28 sera (82.4%) contained Bet v 1-specific IgE. Among the 28 sera with Bet v 1-specific IgE, 27 sera (96.4%) contained Mal d 1-specific IgE and 22 sera (78.6%) contained Gly m 4-specific IgE. Of the 34 Bet v-positive sera, 6 sera (17.6%) contained no specific IgE for Bet v 1, Mal d 1, or Gly m 4. Almost all Bet v-positive sera were donated during the birch pollen season. Conclusions: The prevalence of birch allergy among patients visiting health care during pollen season can be as high as 16.7% in Tangshan City. The majority of Chinese birch allergic patients are IgE-sensitized to the major birch pollen allergen Bet v 1 as well as to the major apple allergen Mal d 1 and soy bean allergen Gly m 4. A relatively high number of patients (17.6%) are IgE-sensitized to birch pollen allergen(s) other than Bet v 1. The high prevalence of specific IgE to Mal d 1 and Gly m 4 among Bet v 1-sensitized patients indicates that pollen-food allergy syndrome could be of clinical relevance in China.

桦树花粉、大豆和苹果过敏原之间高免疫球蛋白E相关性表明中国北方地区桦树花粉过敏患者很可能同时患有花粉-食物综合征

目的:研究中国北方地区桦树花粉过敏及花粉-食物过敏综合征。
创新点:国内首次研究花粉-食物过敏综合征,为中国北方地区此类患者的诊断和治疗提出了新思路。
方法:采集临床中过敏患者血清,检测桦树花粉及其主要过敏原特异性免疫球蛋白E(IgE),同时检测大豆和苹果过敏原的特异性IgE,并评价其相关性。
结论:中国北方地区桦树花粉季节对此花粉过敏的患者有16.7%以上,主要是对桦树花粉第一组过敏原致敏。这些患者大多数同时对大豆和苹果的主要过敏原过敏,这种特异性IgE高相关性说明临床上存在花粉-食物过敏综合征。

关键词:桦树;大豆;苹果;特异性IgE;花粉-食物过敏综合征

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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