CLC number: R593.2
On-line Access: 2016-05-04
Received: 2015-11-11
Revision Accepted: 2016-01-17
Crosschecked: 2016-04-15
Cited: 4
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Guo-dong Hao, Yi-wu Zheng, Zhi-xiang Wang, Xing-ai Kong, Zhi-jing Song, Xu-xin Lai, Michael D. Spangfort. High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China[J]. Journal of Zhejiang University Science B, 2016, 17(5): 399-404.
@article{title="High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China",
author="Guo-dong Hao, Yi-wu Zheng, Zhi-xiang Wang, Xing-ai Kong, Zhi-jing Song, Xu-xin Lai, Michael D. Spangfort",
journal="Journal of Zhejiang University Science B",
volume="17",
number="5",
pages="399-404",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1500279"
}
%0 Journal Article
%T High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China
%A Guo-dong Hao
%A Yi-wu Zheng
%A Zhi-xiang Wang
%A Xing-ai Kong
%A Zhi-jing Song
%A Xu-xin Lai
%A Michael D. Spangfort
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 5
%P 399-404
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500279
TY - JOUR
T1 - High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China
A1 - Guo-dong Hao
A1 - Yi-wu Zheng
A1 - Zhi-xiang Wang
A1 - Xing-ai Kong
A1 - Zhi-jing Song
A1 - Xu-xin Lai
A1 - Michael D. Spangfort
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 5
SP - 399
EP - 404
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500279
Abstract: Background: birch pollen sensitization and associated pollen-food syndrome among Chinese allergic patients have not been investigated. Methods: Sera from 203 allergic patients from the northern part of China and collected during February to July 2014 were investigated. specific immunoglobulin E (IgE) against birch pollen extract Bet v and major birch pollen allergen Bet v 1 were measured using the ADVIA Centaur. The presence of major apple allergen Mal d 1 and soy bean allergen Gly m 4 specific IgE was measured by ImmunoCAP 100. Results: Among the 203 sera, 34 sera (16.7%) had specific IgE to Bet v and of these, 28 sera (82.4%) contained Bet v 1-specific IgE. Among the 28 sera with Bet v 1-specific IgE, 27 sera (96.4%) contained Mal d 1-specific IgE and 22 sera (78.6%) contained Gly m 4-specific IgE. Of the 34 Bet v-positive sera, 6 sera (17.6%) contained no specific IgE for Bet v 1, Mal d 1, or Gly m 4. Almost all Bet v-positive sera were donated during the birch pollen season. Conclusions: The prevalence of birch allergy among patients visiting health care during pollen season can be as high as 16.7% in Tangshan City. The majority of Chinese birch allergic patients are IgE-sensitized to the major birch pollen allergen Bet v 1 as well as to the major apple allergen Mal d 1 and soy bean allergen Gly m 4. A relatively high number of patients (17.6%) are IgE-sensitized to birch pollen allergen(s) other than Bet v 1. The high prevalence of specific IgE to Mal d 1 and Gly m 4 among Bet v 1-sensitized patients indicates that pollen-food allergy syndrome could be of clinical relevance in China.
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