CLC number: R681.5+1
On-line Access: 2016-11-03
Received: 2016-02-24
Revision Accepted: 2016-06-23
Crosschecked: 2016-10-18
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Lie-dao Yu, Zhi-yun Feng, Xuan-wei Wang, Zhi-heng Ling, Xiang-jin Lin. Fungal spondylodiscitis in a patient recovered from H7N9 virus infection: a case study and a literature review of the differences between Candida and Aspergillus spondylodiscitis[J]. Journal of Zhejiang University Science B, 2016, 17(11): 874-881.
@article{title="Fungal spondylodiscitis in a patient recovered from H7N9 virus infection: a case study and a literature review of the differences between Candida and Aspergillus spondylodiscitis",
author="Lie-dao Yu, Zhi-yun Feng, Xuan-wei Wang, Zhi-heng Ling, Xiang-jin Lin",
journal="Journal of Zhejiang University Science B",
volume="17",
number="11",
pages="874-881",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600077"
}
%0 Journal Article
%T Fungal spondylodiscitis in a patient recovered from H7N9 virus infection: a case study and a literature review of the differences between Candida and Aspergillus spondylodiscitis
%A Lie-dao Yu
%A Zhi-yun Feng
%A Xuan-wei Wang
%A Zhi-heng Ling
%A Xiang-jin Lin
%J Journal of Zhejiang University SCIENCE B
%V 17
%N 11
%P 874-881
%@ 1673-1581
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600077
TY - JOUR
T1 - Fungal spondylodiscitis in a patient recovered from H7N9 virus infection: a case study and a literature review of the differences between Candida and Aspergillus spondylodiscitis
A1 - Lie-dao Yu
A1 - Zhi-yun Feng
A1 - Xuan-wei Wang
A1 - Zhi-heng Ling
A1 - Xiang-jin Lin
J0 - Journal of Zhejiang University Science B
VL - 17
IS - 11
SP - 874
EP - 881
%@ 1673-1581
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600077
Abstract: To report a rare case of fungal spondylodiscitis in a patient recovered from h7N9 virus infection and perform a literature review of the different characteristics of Candida and Aspergillus spondylodiscitis, we reviewed cases of spondylodiscitis caused by Candida and Aspergillus species. Data, including patients’ information, pathogenic species, treatment strategy, outcomes, and relapses, were collected and summarized. The characteristics of Candida and Aspergillus spondylodiscitis were compared to see if any differences in clinical features, management, or consequences could be detected. The subject of the case study was first misdiagnosed as having a vertebral tumor, and then, following open biopsy, was diagnosed as having fungal spondylodiscitis. The patient made a good recovery following radical debridement. Seventy-seven additional cases of Candida spondylodiscitis and 94 cases of Aspergillus spondylodiscitis were identified in the literature. Patients with Candida spondylodiscitis tended to have a better outcome than patients with Aspergillus spondylodiscitis (cure rate 92.3% vs. 70.2%). Candida was found more frequently (47.8%) than Aspergillus (26.7%) in blood cultures, while neurological deficits were observed more often in patients with Aspergillus spondylodiscitis (43.6% vs. 25.6%). Candida spinal infections were more often treated by radical debridement (60.5% vs. 39.6%). Patients with Candida spondylodiscitis have better outcomes, which may be associated with prompt recognition, radical surgical debridement, and azoles therapy. A good outcome can be expected in fungal spondylodiscitis with appropriate operations and anti-fungal drugs.
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[38]List of electronic supplementary materials
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