Full Text:   <2636>

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CLC number: R541.7+5

On-line Access: 2017-11-06

Received: 2016-10-31

Revision Accepted: 2017-05-07

Crosschecked: 2017-10-12

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714


Jun Zhu


Chen-yang Jiang


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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.11 P.946-954


Metabolic benefits of rivaroxaban in non-valvular atrial fibrillation patients after radiofrequency catheter ablation

Author(s):  Jun Zhu, Rong-jun Gao, Qiang Liu, Ru-hong Jiang, Lu Yu, Ya-xun Sun, Pei Zhang, Jian-wei Lin, Yang Ye, Zu-wen Zhang, Shi-quan Chen, Hui Cheng, Xia Sheng, Chen-yang Jiang

Affiliation(s):  Department of Cardiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China; more

Corresponding email(s):   cyjiang@zju.edu.cn

Key Words:  Atrial fibrillation, Radiofrequency catheter ablation, Anticoagulation, Rivaroxaban

Jun Zhu, Rong-jun Gao, Qiang Liu, Ru-hong Jiang, Lu Yu, Ya-xun Sun, Pei Zhang, Jian-wei Lin, Yang Ye, Zu-wen Zhang, Shi-quan Chen, Hui Cheng, Xia Sheng, Chen-yang Jiang. Metabolic benefits of rivaroxaban in non-valvular atrial fibrillation patients after radiofrequency catheter ablation[J]. Journal of Zhejiang University Science B, 2017, 18(11): 946-954.

@article{title="Metabolic benefits of rivaroxaban in non-valvular atrial fibrillation patients after radiofrequency catheter ablation",
author="Jun Zhu, Rong-jun Gao, Qiang Liu, Ru-hong Jiang, Lu Yu, Ya-xun Sun, Pei Zhang, Jian-wei Lin, Yang Ye, Zu-wen Zhang, Shi-quan Chen, Hui Cheng, Xia Sheng, Chen-yang Jiang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Metabolic benefits of rivaroxaban in non-valvular atrial fibrillation patients after radiofrequency catheter ablation
%A Jun Zhu
%A Rong-jun Gao
%A Qiang Liu
%A Ru-hong Jiang
%A Lu Yu
%A Ya-xun Sun
%A Pei Zhang
%A Jian-wei Lin
%A Yang Ye
%A Zu-wen Zhang
%A Shi-quan Chen
%A Hui Cheng
%A Xia Sheng
%A Chen-yang Jiang
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 11
%P 946-954
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600492

T1 - Metabolic benefits of rivaroxaban in non-valvular atrial fibrillation patients after radiofrequency catheter ablation
A1 - Jun Zhu
A1 - Rong-jun Gao
A1 - Qiang Liu
A1 - Ru-hong Jiang
A1 - Lu Yu
A1 - Ya-xun Sun
A1 - Pei Zhang
A1 - Jian-wei Lin
A1 - Yang Ye
A1 - Zu-wen Zhang
A1 - Shi-quan Chen
A1 - Hui Cheng
A1 - Xia Sheng
A1 - Chen-yang Jiang
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 11
SP - 946
EP - 954
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600492

Background and objective: rivaroxaban is a new oral anticoagulant for stroke prevention in patients with non-valvular atrial fibrillation (NVAF), which has less drug–food interaction than warfarin. We conducted this prospective randomized study to evaluate the metabolic benefits as well as the safety and efficacy with rivaroxaban versus warfarin in patients with NVAF following radiofrequency catheter ablation (RFCA). Methods: From April to July 2014, 60 patients with NVAF undergoing RFCA were prospectively enrolled in our study. Following RFCA, all patients were randomly assigned to receive rivaroxaban (Group R, n=30) or warfarin (Group W, n=30). Metabolic indices including serum total protein, albumin, globulin, and high-density lipoprotein (HDL) as well as bleeding, stroke, and systemic thromboembolism events were evaluated and compared during follow-up after 15, 30, 60, and 90 d of RFCA procedure. Results: Serum total protein, albumin, globulin, and HDL levels were all significantly elevated at each follow-up stage in Group R when compared to the baseline (P<0.05 respectively). In Group W, the metabolic indices decreased at first and then had an increasing trend. There were no deaths or thromboembolic complications in each group. The prevalence of total bleeding complications was similar between Group R and Group W (11/30, 36.7% vs. 10/30, 33.3%, P=0.79). Conclusions: Patients with NVAF receiving rivaroxaban after RFCA procedures appear to benefit from a metabolic perspective compared with warfarin, providing practical clinical reference for the choice of the anticoagulant. rivaroxaban seems to be as safe and effective in preventing thromboembolic events as warfarin for these patients.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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