Full Text:   <695>

Summary:  <193>

CLC number: 

On-line Access: 2023-03-10

Received: 2022-02-16

Revision Accepted: 2022-06-16

Crosschecked: 2023-03-13

Cited: 0

Clicked: 823

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jiazhou YE

https://orcid.org/0000-0001-9124-7284

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.3 P.191-206

http://doi.org/10.1631/jzus.B2200067


Advances in post-operative prognostic models for hepatocellular carcinoma


Author(s):  Ziqin HE, Xiaomin SHE, Ziyu LIU, Xing GAO, Lu LU, Julu HUANG, Cheng LU, Yan LIN, Rong LIANG, Jiazhou YE

Affiliation(s):  Department of Medical Oncology, Guangxi Medical University Cancer Hospital, Nanning 530021, China; more

Corresponding email(s):   yejiazhou@gxmu.edu.cn

Key Words:  Hepatocellular carcinoma, Clinical stage, Tumor-Node-Metastasis (TNM), Barcelona Clinic Liver Cancer (BCLC), Nomogram


Share this article to: More |Next Article >>>

Ziqin HE, Xiaomin SHE, Ziyu LIU, Xing GAO, Lu LU, Julu HUANG, Cheng LU, Yan LIN, Rong LIANG, Jiazhou YE. Advances in post-operative prognostic models for hepatocellular carcinoma[J]. Journal of Zhejiang University Science B, 2023, 24(3): 191-206.

@article{title="Advances in post-operative prognostic models for hepatocellular carcinoma",
author="Ziqin HE, Xiaomin SHE, Ziyu LIU, Xing GAO, Lu LU, Julu HUANG, Cheng LU, Yan LIN, Rong LIANG, Jiazhou YE",
journal="Journal of Zhejiang University Science B",
volume="24",
number="3",
pages="191-206",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200067"
}

%0 Journal Article
%T Advances in post-operative prognostic models for hepatocellular carcinoma
%A Ziqin HE
%A Xiaomin SHE
%A Ziyu LIU
%A Xing GAO
%A Lu LU
%A Julu HUANG
%A Cheng LU
%A Yan LIN
%A Rong LIANG
%A Jiazhou YE
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 3
%P 191-206
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200067

TY - JOUR
T1 - Advances in post-operative prognostic models for hepatocellular carcinoma
A1 - Ziqin HE
A1 - Xiaomin SHE
A1 - Ziyu LIU
A1 - Xing GAO
A1 - Lu LU
A1 - Julu HUANG
A1 - Cheng LU
A1 - Yan LIN
A1 - Rong LIANG
A1 - Jiazhou YE
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 3
SP - 191
EP - 206
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200067


Abstract: 
hepatocellular carcinoma (HCC) is one of the most common malignancies and a leading cause of cancer-related death worldwide. Surgery remains the primary and most successful therapy option for the treatment of early- and mid-stage HCCs, but the high heterogeneity of HCC renders prognostic prediction challenging. The construction of relevant prognostic models helps to stratify the prognosis of surgically treated patients and guide personalized clinical decision-making, thereby improving patient survival rates. Currently, the prognostic assessment of HCC is based on several commonly used staging systems, such as tumor-Node-Metastasis (TNM), Cancer of the Liver Italian Program (CLIP), and barcelona Clinic Liver Cancer (BCLC). Given the insufficiency of these staging systems and the aim to improve the accuracy of prognostic prediction, researchers have incorporated further prognostic factors, such as microvascular infiltration, and proposed some new prognostic models for HCC. To provide insights into the prospects of clinical oncology research, this review describes the commonly used HCC staging systems and new models proposed in recent years.

肝细胞癌术后预后模型的研究进展

何子勤1,佘晓敏1,刘子钰1,高星1,卢露1,黄菊露2,陆程2,林燕1,梁嵘1,叶甲舟2
1广西医科大学肿瘤医院肿瘤科,中国南宁市,530021
2广西医科大学肿瘤医院肝胆胰脾外科,中国南宁市,530021
概要:肝细胞癌(HCC)是全球最常见的恶性肿瘤之一,同时也是癌症相关死亡的主要原因之一。对于肝癌,尤其是早期和中期肝癌,外科手术是首选同时也是最有效的治疗方法。但HCC的高度异质性,给其患者的预后带来了巨大的挑战。预后模型的构建将有助于对手术治疗患者进行预后分层,并指导临床医生采取个体化治疗,从而提高患者的生存率。目前,HCC的预后评估主要基于几种常用的HCC分期系统(如TNM分期、意大利肝癌计划评分(CLIP)和巴塞罗那分期(BCLC))。然而,鉴于这些分期系统存在的不足,也为了提高预后预测的准确性,研究人员进一步纳入患者的其他预后因素,如微血管浸润,并提出了一些新的预后模型。本综述就当前常见的肝癌临床分期系统及近年提出的新预后模型进行阐述,以期为今后的临床研究提供思路。

关键词:肝细胞癌;临床分期;TNM分期;巴塞罗那分期;列线图

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]AdhouteX, PenarandaG, BronowickiJP, et al., 2015. Usefulness of the HKLC vs. the BCLC staging system in a European HCC cohort. J Hepatol, 62(2):492-493.

[2]AgopianVG, Harlander-LockeM, ZarrinparA, et al., 2015. A novel prognostic nomogram accurately predicts hepatocellular carcinoma recurrence after liver transplantation: analysis of 865 consecutive liver transplant recipients. J Am Coll Surg, 220(4):416-427.

[3]AminMB, GreeneFL, EdgeSB, et al., 2017. The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population-based to a more “personalized” approach to cancer staging. CA Cancer J Clin, 67(2):93-99.

[4]BalachandranVP, GonenM, SmithJJ, et al., 2015. Nomograms in oncology: more than meets the eye. Lancet Oncol, 16(4):e173-e180.

[5]BolondiL, BurroughsA, DufourJF, et al., 2012. Heterogen

[6]eity of patients with intermediate (BCLC B) hepatocellular carcinoma: proposal for a subclassification to facilitate treatment decisions. Semin Liver Dis, 32(4):348-359.

[7]BorzioM, DionigiE, RossiniA, et al., 2018. External validation of the ITA.LI.CA prognostic system for patients with hepatocellular carcinoma: a multicenter cohort study. Hepatology, 67(6):2215-2225.

[8]BrayF, FerlayJ, SoerjomataramI, et al., 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin, 68(6):394-424.

[9]The Cancer of the Liver Italian Program (CLIP) investigators, 1998. A new prognostic system for hepatocellular carcinoma: a retrospective study of 435 patients. Hepatology, 28(3):751-755.

[10]The Cancer of the Liver Italian Program (CLIP) investigators, 2000. Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma. Hepatology, 31(4):840-845.

[11]ChanACY, FanST, PoonRTP, et al., 2013. Evaluation of the seventh edition of the American Joint Committee on Cancer tumour-node-metastasis (TNM) staging system for patients undergoing curative resection of hepatocellular carcinoma: implications for the development of a refined staging system. HPB (Oxford), 15(6):439-448.

[12]ChanAWH, ChongCCN, MoFKF, et al., 2016. Applicability of albumin-bilirubin-based Japan integrated staging score in hepatitis B-associated hepatocellular carcinoma. J Gastroenterol Hepatol, 31(10):1766-1772.

[13]ChanAWH, ZhongJH, BerhaneS, et al., 2018. Development of pre- and post-operative models to predict early recurrence of hepatocellular carcinoma after surgical resection. J Hepatol, 69(6):1284-1293.

[14]ChanSL, MoFKF, JohnsonPJ, et al., 2011. Prospective validation of the Chinese University Prognostic Index and comparison with other staging systems for hepatocellular carcinoma in an Asian population. J Gastroenterol Hepatol, 26(2):340-347.

[15]ChanSL, JohnsonPJ, MoF, et al., 2014. International validation of the Chinese University Prognostic Index for staging of hepatocellular carcinoma: a joint United Kingdom and Hong Kong study. Chin J Cancer, 33(10):481-491.

[16]ChenLJ, ChangYJ, ChangYJ, 2021. Survival predictability between the American Joint Committee on Cancer 8th edition staging system and the Barcelona Clinic Liver Cancer classification in patients with hepatocellular carcinoma. Oncologist, 26(3):e445-e453.

[17]ChenWQ, ZhengRS, BaadePD, et al., 2016. Cancer statistics in China, 2015. CA Cancer J Clin, 66(2):115-132.

[18]ChunYS, PawlikTM, VautheyJN, 2018. 8th Edition of the AJCC Cancer Staging Manual: pancreas and hepatobiliary cancers. Ann Surg Oncol, 25(4):845-847.

[19]CongWM, BuH, ChenJ, et al., 2016. Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update. World J Gastroenterol, 22(42):9279-9287.

[20]di SandroS, CentonzeL, PinottiE, et al., 2019. Surgical and oncological outcomes of hepatic resection for BCLC-B hepatocellular carcinoma: a retrospective multicenter analysis among 474 consecutive cases. Updates Surg, 71(2):285-293.

[21]European Association for the Study of the Liver, 2018. EASL Clinical Practice Guidelines: management of hepatocellular carcinoma. J Hepatol, 69(1):182-236.

[22]FarinatiF, VitaleA, SpolveratoG, et al., 2016. Development and validation of a new prognostic system for patients with hepatocellular carcinoma. PLoS Med, 13(4):e1002006.

[23]FilgueiraNA, 2019. Hepatocellular carcinoma recurrence after liver transplantation: risk factors, screening and clinical presentation. World J Hepatol, 11(3):261-272.

[24]FornerA, ReigM, BruixJ, 2018. Hepatocellular carcinoma. Lancet, 391(10127):1301-1314.

[25]GianniniEG, MoscatelliA, PellegattaG, et al., 2016. Application of the intermediate-stage subclassification to patients with untreated hepatocellular carcinoma. Am J Gastroenterol, 111(1):70-77.

[26]GianniniEG, BucciL, GarutiF, et al., 2018. Patients with advanced hepatocellular carcinoma need a personalized management: a lesson from clinical practice. Hepatology, 67(5):1784-1796.

[27]GrandhiMS, KimAK, Ronnekleiv-KellySM, et al., 2016. Hepatocellular carcinoma: from diagnosis to treatment. Surg Oncol, 25(2):74-85.

[28]HalazunKJ, HardyMA, RanaAA, et al., 2009. Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma. Ann Surg, 250(1):141-151.

[29]HalazunKJ, NajjarM, AbdelmessihRM, et al., 2017. Recurrence after liver transplantation for hepatocellular carcin

[30]oma: a new MORAL to the story. Ann Surg, 265(3):‍557-564.

[31]HeW, PengBG, TangYQ, et al., 2018. Nomogram to predict survival of patients with recurrence of hepatocellular carcinoma after surgery. Clin Gastroenterol Hepatol, 16(5):756-764.e10.

[32]HouYF, WeiYG, YangJY, et al., 2016. Combined hepatectomy and radiofrequency ablation versus TACE in improving survival of patients with unresectable BCLC stage B HCC. Hepatobiliary Pancreat Dis Int, 15(4):378-385.

[33]HuoRR, LiuX, CuiJ, et al., 2020. Development and valid

[34]ation of a nomogram for assessing survival in patients with hepatocellular carcinoma after hepatectomy. Biosci Rep, 40(6):BSR20192690.

[35]JunCH, YoonJH, ChoE, et al., 2017. Barcelona clinic liver cancer-stage C hepatocellular carcinoma: a novel approach to subclassification and treatment. Medicine (Baltimore), 96(17):e6745.

[36]KamarajahSK, FrankelTL, SonnendayC, et al., 2018. Critical evaluation of the American Joint Commission on Cancer (AJCC) 8th edition staging system for patients with Hepatocellular Carcinoma (HCC): a Surveillance, Epidemiology, End Results (SEER) analysis. J Surg Oncol, 117(4):644-650.

[37]KimJH, ShimJH, LeeHC, et al., 2017. New intermediate-stage subclassification for patients with hepatocellular carcinoma treated with transarterial chemoembolization. Liver Int, 37(12):1861-1868.

[38]KollyP, ReevesH, SangroB, et al., 2016. Assessment of the Hong Kong Liver Cancer staging system in Europe. Liver Int, 36(6):911-917.

[39]KudoM, ChungH, OsakiY, 2003. Prognostic staging system for hepatocellular carcinoma (CLIP score): its value and limitations, and a proposal for a new staging system, the Japan Integrated Staging score (JIS score). J Gastroenterol, 38(3):207-215.

[40]KulikL, El-SeragHB, 2019. Epidemiology and management of hepatocellular carcinoma. Gastroenterology, 156(2):477-491.e1.

[41]LeeYS, SeoYS, KimJH, et al., 2018. Can more aggressive treatment improve prognosis in patients with hepatocellular carcinoma? A direct comparison of the Hong Kong Liver Cancer and Barcelona Clinic Liver Cancer algorithms. Gut Liver, 12(1):94-101.

[42]LeungTWT, TangAMY, ZeeB, et al., 2002. Construction of the Chinese University Prognostic Index for hepatocellular carcinoma and comparison with the TNM staging system, the Okuda staging system, and the Cancer of the Liver Italian Program staging system: a study based on 926 patients. Cancer, 94(6):1760-1769.

[43]LiaoMJ, SunJR, ZhangQF, et al., 2021. A novel post-operative ALRI model accurately predicts clinical outcomes of resected hepatocellular carcinoma patients. Front Oncol, 11:665497.

[44]MarreroJA, KulikLM, SirlinCB, et al., 2018. Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology, 68(2):723-750.

[45]MazzaferroV, SpositoC, ZhouJ, et al., 2018. Metroticket 2.0 model for analysis of competing risks of death after liver transplantation for hepatocellular carcinoma. Gastroenterology, 154(1):128-139.

[46]MorisD, ShawBI, McElroyL, et al., 2020. Using hepatocellular carcinoma tumor burden score to stratify prognosis after liver transplantation. Cancers (Basel), 12(11):3372.

[47]NanashimaA, SumidaY, MorinoS, et al., 2004. The Japanese integrated staging score using liver damage grade for hepatocellular carcinoma in patients after hepatectomy. Eur J Surg Oncol, 30(7):765-770.

[48]NanashimaA, SumidaY, AboT, et al., 2006. Modified Japan Integrated Staging is currently the best available staging system for hepatocellular carcinoma patients who have undergone hepatectomy. J Gastroenterol, 41(3):250-256.

[49]NoordzijM, LeffondréK, van StralenKJ, et al., 2013. When do we need competing risks methods for survival analysis in nephrology? Nephrol Dial Transplant, 28(11):2670-2677.

[50]OkudaK, ObataH, NakajimaY, et al., 1984. Prognosis of primary hepatocellular carcinoma. Hepatology, 4(S1):3S-6S.

[51]ParikhND, SingalAG, 2016. The ITA.LI.CA staging system: a novel staging system for hepatocellular carcinoma. PLoS Med, 13(4):e1002005.

[52]ParkS, ChoiS, ChoYA, et al., 2020. Evaluation of the American Joint Committee on Cancer (AJCC) 8th edition staging system for hepatocellular carcinoma in 1008 patients with curative resection. Cancer Res Treat, 52(4):1145-1152.

[53]QinW, WangL, HuBY, et al., 2019. A novel score predicts HBV-related hepatocellular carcinoma recurrence after hepatectomy: a retrospective multicenter study. J Gastrointest Surg, 23(5):922-932.

[54]ReigM, FornerA, RimolaJ, et al., 2022. BCLC strategy for prognosis prediction and treatment recommendation: the 2022 update. J Hepatol, 76(3):681-693.

[55]SelbyLKF, TayRXY, WoonWWL, et al., 2017. Validity of the Barcelona Clinic Liver Cancer and Hong Kong Liver Cancer staging systems for hepatocellular carcinoma in Singapore. J Hepatobiliary Pancreat Sci, 24(3):143-152.

[56]ShindohJ, AndreouA, AloiaTA, et al., 2013. Microvascular invasion does not predict long-term survival in hepatocellular carcinoma up to 2 cm: reappraisal of the staging system for solitary tumors. Ann Surg Oncol, 20(4):1223-1229.

[57]SinnDH, ChoJY, GwakGY, et al., 2015. Different survival of Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma patients by the extent of portal vein invasion and the type of extrahepatic spread. PLoS ONE, 10(4):e0124434.

[58]SuLH, ZhouT, ZhangZL, et al., 2016. Optimal staging system for predicting the prognosis of patients with hepatocellular carcinoma in China: a retrospective study. BMC Cancer, 16:1245.

[59]TabrizianP, JibaraG, ShragerB, et al., 2015. Recurrence of hepatocellular cancer after resection: patterns, treatments, and prognosis. Ann Surg, 261(5):947-955.

[60]TellapuriS, SutphinPD, BegMS, et al., 2018. Staging systems of hepatocellular carcinoma: a review. Indian J Gastroenterol, 37(6):481-491.

[61]VernaEC, PatelYA, AggarwalA, et al., 2020. Liver transplantation for hepatocellular carcinoma: management after the transplant. Am J Transplant, 20(2):333-347.

[62]VitaleA, FarinatiF, NoaroG, et al., 2018. Restaging patients with hepatocellular carcinoma before additional treatment decisions: a multicenter cohort study. Hepatology, 68(4):1232-1244.

[63]WadaH, EguchiH, NodaT, et al., 2016. Selection criteria for hepatic resection in intermediate-stage (BCLC stage B) multiple hepatocellular carcinoma. Surgery, 160(5):1227-1235.

[64]WangCW, HeW, YuanYC, et al., 2020. Comparison of the prognostic value of inflammation-based scores in early recurrent hepatocellular carcinoma after hepatectomy. Liver Int, 40(1):229-239.

[65]WangHB, LuZM, ZhaoXX, 2019. Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer. J Hematol Oncol, 12:133.

[66]WangL, XianYT, YangZQ, 2019. Comparison of 10 prognostic staging systems in patients with advanced hepatocellular carcinoma. J BUON, 24(1):150-157.

[67]XuLL, LiL, WangP, et al., 2019. Novel prognostic nomograms for hepatocellular carcinoma patients with microvascular invasion: experience from a single center. Gut Liver, 13(6):669-682.

[68]XuW, LiRN, LiuF, 2020. Novel prognostic nomograms for predicting early and late recurrence of hepatocellular carcinoma after curative hepatectomy. Cancer Manag Res, 12:1693-1712.

[69]YanXP, FuX, CaiC, et al., 2015. Validation of models in patients with hepatocellular carcinoma: comparison of Hong Kong Liver Cancer with Barcelona Clinic Liver Cancer staging system in a Chinese cohort. Eur J Gastroenterol Hepatol, 27(10):1180-1186.

[70]YauT, TangVYF, YaoTJ, et al., 2014. Development of Hong Kong Liver Cancer staging system with treatment stratification for patients with hepatocellular carcinoma. Gastroenterology, 146(7):1691-1700.e3.

[71]ZhangGQ, LiRF, ZhaoXY, et al., 2018. Validation of the American Joint Committee on Cancer eighth edition staging system in patients undergoing hepatectomy for hepatocellular carcinoma: a US population-based study. J Surg Res, 222:55-68.

[72]ZhangXP, WangK, WeiXB, et al., 2019. An Eastern Hepatobiliary Surgery Hospital microvascular invasion scoring system in predicting prognosis of patients with hepatocellular carcinoma and microvascular invasion after R0 liver resection: a large-scale, multicenter study. Oncologist, 24(12):e1476-e1488.

[73]ZhangZH, ShenSL, ChenB, et al., 2019. Hepatic resection provides survival benefit for selected intermediate-stage (BCLC-B) hepatocellular carcinoma patients. Cancer Res Treat, 51(1):65-72.

[74]ZhongJH, KeY, GongWF, et al., 2014. Hepatic resection associated with good survival for selected patients with intermediate and advanced-stage hepatocellular carcinoma. Ann Surg, 260(2):329-340.

[75]ZhouJ, SunHC, WangZ, et al., 2020. Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition). Liver Cancer, 9(6):682-720.

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE