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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2200174


Tertiary lymphoid structures as unique constructions associated with the organization, education and function of tumor infiltrating immunocytes


Author(s):  Jing CHEN, Jian CHEN, Lie WANG

Affiliation(s):  Department of Gastrointestinal Surgery of the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310000, China; more

Corresponding email(s):   wanglie@zju.edu.cn, zrchenjian@zju.edu.cn

Key Words:  Tertiary lymphoid structures, Tumor infiltrating immunocytes, Tumor microenvironment


Jing CHEN, Jian CHEN, Lie WANG. Tertiary lymphoid structures as unique constructions associated with the organization, education and function of tumor infiltrating immunocytes[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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Abstract: 
tertiary lymphoid structures (TLSs) are formations at sites with persistent inflammatory stimulation, including tumors. These ectopic lymphoid organs mainly consist of chemo-attracting B cells, T cells, and supporting dendritic cells (DC). Mature TLSs exhibit functional organization for the optimal development and collaboration of adaptive immune response, delivering an augmented effect on the tumor microenvironment (TME). The description of the positive correlation between TLSs and tumor prognosis is reliable only under a certain condition involving the localization and maturation of TLSs. Emerging evidence suggests that underlying mechanisms of the anti-tumor effect of TLSs pave the way for novel immunotherapies. Several approaches have been developed to take advantage of intratumoral TLSs, either by combining it with therapeutic agents, or by inducing the neogenesis of TLSs.

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