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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.1 P.1-22


Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases

Author(s):  Yi LUAN, Yang YANG, Ying LUAN, Hui LIU, Han XING, Jinyan PEI, Hengdao LIU, Bo QIN, Kaidi REN

Affiliation(s):  Clinical Systems Biology Research Laboratories, Translational Medicine Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; more

Corresponding email(s):   renkd006@163.com, boqin@mail.ustc.edu.cn, fccliuhd@zzu.edu.cn

Key Words:  Cardiovascular disease, Iron, Ferroptosis, Ferritinophagy, Therapeutic target

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Yi LUAN, Yang YANG, Ying LUAN, Hui LIU, Han XING, Jinyan PEI, Hengdao LIU, Bo QIN, Kaidi REN. Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases[J]. Journal of Zhejiang University Science B, 2024, 25(1): 1-22.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%A Yang YANG
%A Ying LUAN
%A Hui LIU
%A Jinyan PEI
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%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300097

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A1 - Yi LUAN
A1 - Yang YANG
A1 - Ying LUAN
A1 - Hui LIU
A1 - Han XING
A1 - Jinyan PEI
A1 - Hengdao LIU
A1 - Bo QIN
A1 - Kaidi REN
J0 - Journal of Zhejiang University Science B
VL - 25
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2300097

cardiovascular diseases (CVDs) are a leading factor driving mortality worldwide. iron, an essential trace mineral, is important in numerous biological processes, and its role in CVDs has raised broad discussion for decades. iron-mediated cell death, namely ferroptosis, has attracted much attention due to its critical role in cardiomyocyte damage and CVDs. Furthermore, ferritinophagy is the upstream mechanism that induces ferroptosis, and is closely related to CVDs. This review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy, and the regulatory pathways and molecular targets involved in ferritinophagy, and to determine their roles in CVDs. Furthermore, we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating CVDs. Collectively, this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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