CLC number:
On-line Access: 2024-01-02
Received: 2023-02-13
Revision Accepted: 2023-05-21
Crosschecked: 2024-01-02
Cited: 0
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Yi LUAN, Yang YANG, Ying LUAN, Hui LIU, Han XING, Jinyan PEI, Hengdao LIU, Bo QIN, Kaidi REN. Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases[J]. Journal of Zhejiang University Science B, 2024, 25(1): 1-22.
@article{title="Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases",
author="Yi LUAN, Yang YANG, Ying LUAN, Hui LIU, Han XING, Jinyan PEI, Hengdao LIU, Bo QIN, Kaidi REN",
journal="Journal of Zhejiang University Science B",
volume="25",
number="1",
pages="1-22",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300097"
}
%0 Journal Article
%T Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases
%A Yi LUAN
%A Yang YANG
%A Ying LUAN
%A Hui LIU
%A Han XING
%A Jinyan PEI
%A Hengdao LIU
%A Bo QIN
%A Kaidi REN
%J Journal of Zhejiang University SCIENCE B
%V 25
%N 1
%P 1-22
%@ 1673-1581
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300097
TY - JOUR
T1 - Targeting ferroptosis and ferritinophagy: new targets for cardiovascular diseases
A1 - Yi LUAN
A1 - Yang YANG
A1 - Ying LUAN
A1 - Hui LIU
A1 - Han XING
A1 - Jinyan PEI
A1 - Hengdao LIU
A1 - Bo QIN
A1 - Kaidi REN
J0 - Journal of Zhejiang University Science B
VL - 25
IS - 1
SP - 1
EP - 22
%@ 1673-1581
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300097
Abstract: cardiovascular diseases (CVDs) are a leading factor driving mortality worldwide. iron, an essential trace mineral, is important in numerous biological processes, and its role in CVDs has raised broad discussion for decades. iron-mediated cell death, namely ferroptosis, has attracted much attention due to its critical role in cardiomyocyte damage and CVDs. Furthermore, ferritinophagy is the upstream mechanism that induces ferroptosis, and is closely related to CVDs. This review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy, and the regulatory pathways and molecular targets involved in ferritinophagy, and to determine their roles in CVDs. Furthermore, we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating CVDs. Collectively, this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.
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