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 ORCID:

Qingqing WANG

https://orcid.org/0000-0002-0415-0052

Yin SHI

https://orcid.org/0000-0003-3858-8500

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Journal of Zhejiang University SCIENCE B 2025 Vol.26 No.3 P.203-226

http://doi.org/10.1631/jzus.B2300492


Immune checkpoint blockade for cancer therapy: current progress and perspectives


Author(s):  Hongying YE, Weijie LIAO, Jiongli PAN, Yin SHI, Qingqing WANG

Affiliation(s):  Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China; more

Corresponding email(s):   wqq@zju.edu.cn, yinshi@zju.edu.cn

Key Words:  Immune checkpoint blockade, Cancer immunotherapy, Tumor immune evasion, Immune normalization


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Hongying YE, Weijie LIAO, Jiongli PAN, Yin SHI, Qingqing WANG. Immune checkpoint blockade for cancer therapy: current progress and perspectives[J]. Journal of Zhejiang University Science B, 2025, 26(3): 203-226.

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year="2025",
publisher="Zhejiang University Press & Springer",
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Abstract: 
Dysfunction of anti-tumor immune responses is crucial for cancer progression. immune checkpoint blockade (ICB), which can potentiate T cell responses, is an effective strategy for the normalization of host anti-tumor immunity. In recent years, immune checkpoints, expressed on both tumor cells and immune cells, have been identified; some of them have exhibited potential druggability and have been approved by the US Food and Drug Administration (FDA) for clinical treatment. However, limited responses and immune-related adverse events (irAEs) cannot be ignored. This review outlines the development and applications of ICBs, potential strategies for overcoming resistance, and future directions for ICB-based cancer immunotherapy.

免疫检查点阻断的癌症治疗:最新进展与展望

叶弘颖1,2,廖炜杰1,2,潘炯利1,2,诗音3,王青青1,2
1浙江大学医学院免疫学研究所,中国杭州市,310058
2浙江省免疫与炎症疾病重点实验室,中国杭州市,310058
3浙江大学医学院生物化学系,中国杭州市,310058
摘要:抗肿瘤免疫反应的功能缺陷对癌症进展至关重要。免疫检查点阻断(ICB)可增强T细胞反应,是宿主抗肿瘤免疫正常化的有效策略。近年来,多项表达于肿瘤细胞和免疫细胞的免疫检查点已被鉴定,其中一些显示出良好的成药性,并已获得美国食品药品监督管理局(FDA)的批准用于临床治疗。然而,有限的治疗反应和免疫相关不良事件(irAEs)不容忽视。本文综述了ICB的发展和应用,并就基于ICB的癌症免疫疗法克服耐药性的潜在策略和未来方向展开讨论。

关键词:免疫检查点阻断;癌症免疫疗法;肿瘤免疫逃逸;免疫正常化

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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