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Abstract: White-matter tracts play a pivotal role in transmitting sensory and motor information, facilitating interhemispheric communication and integrating different brain regions. Meanwhile, sensorimotor disturbance is a common symptom in patients with major depressive disorder (MDD). However, the role of aberrant sensorimotor white-matter system in MDD remains largely unknown. Herein, we investigated the topological structure alterations of white-matter morphological brain networks in 233 MDD patients versus 257 matched healthy controls (HCs) from the DIRECT consortium. White-matter networks were derived from magnetic resonance imaging (MRI) data by combining voxel-based morphometry (VBM) and three-dimensional discrete wavelet transform (3D-DWT) approaches. Support vector machine (SVM) analysis was performed to discriminate MDD patients from HCs. The results indicated that the network topological changes in node degree, node efficiency, and node betweenness were mainly located in the sensorimotor superficial white-matter system in MDD. Using network nodal topological properties as classification features, the SVM model could effectively distinguish MDD patients from HCs. These findings provide new evidence to highlight the importance of the sensorimotor system in brain mechanisms underlying MDD from a new perspective of white-matter morphological network.

重度抑郁症感觉运动浅表白质系统的网络拓扑结构异常

[1]Alexander-BlochA,ClasenL,StockmanM,et al.,2016.Subtle in-scanner motion biases automated measurement of brain anatomy from in vivo MRI.Hum Brain Mapp,37(7):2385-2397.

[2]AshburnerJ,2007.A fast diffeomorphic image registration algorithm.NeuroImage,38(1):95-113.

[3]AydoganDB,JacobsR,DulawaS,et al.,2018.When tractography meets tracer injections: a systematic study of trends and variation sources of diffusion-based connectivity.Brain Struct Funct,223(6):2841-2858.

[4]BassettDS,SpornsO,2017.Network neuroscience.Nat Neurosci,20(3):353-364.

[5]BaumGL,RoalfDR,CookPA,et al.,2018.The impact of in-scanner head motion on structural connectivity derived from diffusion MRI.NeuroImage,173:275-286.

[6]BullmoreE,SpornsO,2012.The economy of brain network organization.Nat Rev Neurosci,13(5):336-349.

[7]CanbeyliR,2013.Sensorimotor modulation of mood and depression: in search of an optimal mode of stimulation.Front Hum Neurosci,7:428.

[8]ChenX,LuB,LiHX,et al.,2022.The direct consortium and the REST-meta-MDD project: towards neuroimaging biomarkers of major depressive disorder.Psychoradiology,2(1):32-42.

[9]FanYS,LiZH,DuanXJ,et al.,2020.Impaired interactions among white-matter functional networks in antipsychotic-naive first-episode schizophrenia.Hum Brain Mapp,41(1):230-240.

[10]FieldsRD,2010.Change in the brain’s white matter.Science,330(6005):768-769.

[11]FilleyCM,1998.The behavioral neurology of cerebral white matter.Neurology,50(6):1535-1540.

[12]FortinJP,CullenN,ShelineYI,et al.,2018.Harmonization of cortical thickness measurements across scanners and sites.NeuroImage,167:104-120.

[13]GeorgiadisF,LarivièreS,GlahnD,et al.,2024.Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study.Mol Psychiatry,29:1869-1881.

[14]HoneyCJ,ThiviergeJP,SpornsO,2010.Can structure predict function in the human brain?NeuroImage,52(3):766-776.

[15]IwabuchiSJ,KrishnadasR,LiCB,et al.,2015.Localized connectivity in depression: a meta-analysis of resting state functional imaging studies.Neurosci Biobehav Rev,51:77-86.

[16]KorgaonkarMS,FornitoA,WilliamsLM,et al.,2014.Abnormal structural networks characterize major depressive disorder: a connectome analysis.Biol Psychiatry,76(7):567-574.

[17]LiHR,YangJ,YinL,et al.,2021.Alteration of single-subject gray matter networks in major depressed patients with suicidality.J Magn Reson Imaging,54(1):215-224.

[18]LiJ,ChenH,FanFY,et al.,2020.White-matter functional topology: a neuromarker for classification and prediction in unmedicated depression.Transl Psychiat,10:365.

[19]LiJL,LiZ,YangYP,et al.,2023.Morphological brain networks of white matter: mapping, evaluation, characterization, and application.Adv Sci,11(35):e2400061.

[20]LiaoXH,VasilakosAV,HeY,2017.Small-world human brain networks: perspectives and challenges.Neurosci Biobehav Rev,77:286-300.

[21]LuFM,CuiQ,HuangXJ,et al.,2020.Anomalous intrinsic connectivity within and between visual and auditory networks in major depressive disorder.Prog Neuro-Psychopharmacol Biol Psychiatry,100:109889.

[22]LuscherB,ShenQ,SahirN,2011.The GABaergic deficit hypothesis of major depressive disorder.Mol Psychiatry,16(4):383-406.

[23]MaN,LiLJ,ShuN,et al.,2007.White matter abnormalities in first-episode, treatment-naive young adults with major depressive disorder.Am J Psychiatry,164(5):823-826.

[24]MalhiGS,MannJJ,2018.Depression.Lancet,392(10161):2299-2312.

[25]MaslovS,SneppenK,2002.Specificity and stability in topology of protein networks.Science,296(5569):910-913.

[26]MeinertzhagenIA,2018.Of what use is connectomics?A personal perspective on the Drosophila connectome. J Exp Biol,221(10):jeb164954.

[27]NakanoT,TakamuraM,IchikawaN,et al.,2020.Enhancing multi-center generalization of machine learning-based depression diagnosis from resting-state fMRI.Front Psychiatry,11:400.

[28]PardoeHR,MartinSP,2022.In-scanner head motion and structural covariance networks.Hum Brain Mapp,43(14):4335-4346.

[29]PeerM,NitzanM,BickAS,et al.,2017.Evidence for functional networks within the human brain’s white matter.J Neurosci,37(27):6394-6407.

[30]PetersenSE,SpornsO,2015.Brain networks and cognitive architectures.Neuron,88(1):207-219.

[31]PetrellaJR,2011.Use of graph theory to evaluate brain networks: a clinical tool for a small world?Radiology,259(2):317-320.

[32]PowerJD,CohenAL,NelsonSM,et al.,2011.Functional network organization of the human brain.Neuron,72(4):665-678.

[33]RamasubbuR,BrownMRG,CorteseF,et al.,2016.Accuracy of automated classification of major depressive disorder as a function of symptom severity.NeuroImage Clin,12:320-331.

[34]Sampaio-BaptistaC,Johansen-BergH,2017.White matter plasticity in the adult brain.Neuron,96(6):1239-1251.

[35]SchillingKG,GaoYR,StepniewskaI,et al.,2019.Anatomical accuracy of standard-practice tractography algorithms in the motor system‍ –‍ a histological validation in the squirrel monkey brain.Magn Reson Imaging,55:7-25.

[36]SeidlitzJ,VášaF,ShinnM,et al.,2018.Morphometric similarity networks detect microscale cortical organization and predict inter-individual cognitive variation.Neuron,97(1):231-247.e7.

[37]ShiYC,ZhangLH,WangZ,et al.,2021.Multivariate machine learning analyses in identification of major depressive disorder using resting-state functional connectivity: a multicentral study.ACS Chem Neurosci,12(15):‍2878-2886.

[38]WangJH,WangXD,XiaMR,et al.,2015.GRETNA: a graph theoretical network analysis toolbox for imaging connectomics.Front Hum Neurosci,9:386.

[39]WangP,WangJL,MichaelA,et al.,2022.White matter functional connectivity in resting-state fMRI: robustness, reliability, and relationships to gray matter.Cereb Cortex,32(8):1547-1559.

[40]WangXH,ZhaoBH,LiLH,2022.Mapping white matter structural covariance connectivity for single subject using wavelet transform with T1-weighted anatomical brain MRI.Front Neurosci,16:1038514.

[41]WangY,LiuG,HongDD,et al.,2016.White matter injury in ischemic stroke.Prog Neurobiol,141:45-60.

[42]WhitwellJL,2009.Voxel-based morphometry: an automated technique for assessing structural changes in the brain.J Neurosci,29(31):9661-9664.

[43]XiaoY,ZhaoL,ZangXL,et al.,2023.Compressed primary-to-transmodal gradient is accompanied with subcortical alterations and linked to neurotransmitters and cellular signatures in major depressive disorder.Hum Brain Mapp,44(17):5919-5935.

[44]YanCG,ChenX,LiL,et al.,2019.Reduced default mode network functional connectivity in patients with recurrent major depressive disorder.Proc Natl Acad Sci USA,116(18):9078-9083.

[45]YangH,ChenX,ChenZB,et al.,2021.Disrupted intrinsic functional brain topology in patients with major depressive disorder.Mol Psychiatry,26(12):7363-7371.

[46]YeoBTT,KrienenFM,SepulcreJ,et al.,2011.The organization of the human cerebral cortex estimated by intrinsic functional connectivity.J Neurophysiol,106(3):1125-1165.

[47]ZaleskyA,FornitoA,HardingIH,et al.,2010.Whole-brain anatomical networks: does the choice of nodes matter?NeuroImage,50(3):970-983.

[48]ZhangFF,PengW,SweeneyJA,et al.,2018.Brain structure alterations in depression: psychoradiological evidence.CNS Neurosci Ther,24(11):994-1003.

[49]ZhangYR,LiuXY,HouZH,et al.,2021.Global topology alteration of the brain functional network affects the 8-week antidepressant response in major depressive disorder.J Affect Disord,294:491-496.

[50]ZhangZQ,LiaoW,ChenHF,et al.,2011.Altered functional–structural coupling of large-scale brain networks in idiopathic generalized epilepsy.Brain,134(10):2912-2928.

[51]ZhouY,ZhuYH,YeHT,et al.,2024.Abnormal changes of dynamic topological characteristics in patients with major depressive disorder.J Affect Disord,345:349-357.