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On-line Access: 2025-03-13
Received: 2024-01-07
Revision Accepted: 2024-02-15
Crosschecked: 2025-03-13
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Citations: Bibtex RefMan EndNote GB/T7714
https://orcid.org/0000-0002-4270-671X
https://orcid.org/0000-0001-8542-1688
Ziyin YANG, Lei HAI, Xiaoyu CHEN, Siwen WU, Yan LV, Dawei CUI, Jue XIE. OX40 ligand promotes follicular helper T cell differentiation and development in mice with immune thrombocytopenia[J]. Journal of Zhejiang University Science B, 2025, 26(3): 240-253.
@article{title="OX40 ligand promotes follicular helper T cell differentiation and development in mice with immune thrombocytopenia",
author="Ziyin YANG, Lei HAI, Xiaoyu CHEN, Siwen WU, Yan LV, Dawei CUI, Jue XIE",
journal="Journal of Zhejiang University Science B",
volume="26",
number="3",
pages="240-253",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300947"
}
%0 Journal Article
%T OX40 ligand promotes follicular helper T cell differentiation and development in mice with immune thrombocytopenia
%A Ziyin YANG
%A Lei HAI
%A Xiaoyu CHEN
%A Siwen WU
%A Yan LV
%A Dawei CUI
%A Jue XIE
%J Journal of Zhejiang University SCIENCE B
%V 26
%N 3
%P 240-253
%@ 1673-1581
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300947
TY - JOUR
T1 - OX40 ligand promotes follicular helper T cell differentiation and development in mice with immune thrombocytopenia
A1 - Ziyin YANG
A1 - Lei HAI
A1 - Xiaoyu CHEN
A1 - Siwen WU
A1 - Yan LV
A1 - Dawei CUI
A1 - Jue XIE
J0 - Journal of Zhejiang University Science B
VL - 26
IS - 3
SP - 240
EP - 253
%@ 1673-1581
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300947
Abstract: immune thrombocytopenia (ITP) is a hemorrhagic autoimmune disease characterized by antibody-mediated platelet injury. ITP has complicated immunopathological mechanisms that need further elucidation. It is well known that the costimulatory molecules OX40 ligand (OX40L) and OX40 play essential roles in the immunological mechanisms of autoimmune diseases. Previously, we discovered that the expression ofOX40L andOX40 is significantly increased in the peripheral blood mononuclear cells (PBMCs) of ITP patients. In our present study, OX40L-induced follicular helper T (Tfh) cells exhibited an activated phenotype with elevated expression of inducible T-cell costimulator (ICOS), programmed cell death protein-1 (PD-1), and cluster of differentiation 40 ligand (CD40L) in vitro. Moreover, aberrant OX40L‒OX40 expression might promote the Tfh1-to-Tfh2 shift in vivo, inducing the generation of autoantibodies by enhancing the helper function of Tfh cells for B lymphocytes in a mouse model, which might accelerate the progression of ITP. Additionally, signal transduction through the OX40L‒OX40 axis might be related to the activation of tumor necrosis factor receptor-associated factor (TRAF)‒nuclear factor-κB (NF-κB) and Janus kinase (JAK)‒signal transducer and activator of transcription (STAT) signaling pathways. Overall, OX40L‒OX40 signaling is proposed as a potential novel therapeutic target for ITP.
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