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Received: 2023-10-17
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Design and realization of lung organoid cultures for COVID-19 applications
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Bing Ren, Tryanni R. Chiaravalloti, Nadine L. Belony, Diana I. Romero, Wenxuan Chai, Christopher Leon, Lizi Wu, Nazarius S. Lamango, Ite A. Offringa & Yong Huang. Design and realization of lung organoid cultures for COVID-19 applications[J]. Journal of Zhejiang University Science D, 2023, 6(6): 646-660.
@article{title="Design and realization of lung organoid cultures for COVID-19 applications",
author="Bing Ren, Tryanni R. Chiaravalloti, Nadine L. Belony, Diana I. Romero, Wenxuan Chai, Christopher Leon, Lizi Wu, Nazarius S. Lamango, Ite A. Offringa & Yong Huang",
journal="Journal of Zhejiang University Science D",
volume="6",
number="6",
pages="646-660",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-023-00255-1"
}
%0 Journal Article
%T Design and realization of lung organoid cultures for COVID-19 applications
%A Bing Ren
%A Tryanni R. Chiaravalloti
%A Nadine L. Belony
%A Diana I. Romero
%A Wenxuan Chai
%A Christopher Leon
%A Lizi Wu
%A Nazarius S. Lamango
%A Ite A. Offringa & Yong Huang
%J Journal of Zhejiang University SCIENCE D
%V 6
%N 6
%P 646-660
%@ 1869-1951
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-023-00255-1
TY - JOUR
T1 - Design and realization of lung organoid cultures for COVID-19 applications
A1 - Bing Ren
A1 - Tryanni R. Chiaravalloti
A1 - Nadine L. Belony
A1 - Diana I. Romero
A1 - Wenxuan Chai
A1 - Christopher Leon
A1 - Lizi Wu
A1 - Nazarius S. Lamango
A1 - Ite A. Offringa & Yong Huang
J0 - Journal of Zhejiang University Science D
VL - 6
IS - 6
SP - 646
EP - 660
%@ 1869-1951
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-023-00255-1
Abstract: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has spread globally and threatens public health. Advanced in vitro models that recapitulate the architecture and functioning of specific tissues and organs are in high demand for COVID-19-related pathology studies and drug screening. Since three-dimensional in vitro cultures, such as self-assembled and engineered organoid cultures, surpass conventional two-dimensional cultures and animal models with respect to increased cellular complexity, an environment more relevant to humans, and reduced cost, they are promising platforms for understanding viral pathogenesis and developing new therapeutics. This review highlights the recent advances in self-assembled and engineered organoid technologies that are used for COVID-19 studies. The challenges and future perspectives are also discussed.
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