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Dual-functional chameleon microneedles based on Cel/Fe-GA-OKGM/Gel for programmed biofilm eradication and real-time healing surveillance in chronic wounds
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Xi Pan, Qida Zong, Qianwen Zhang, Ruizeng Luo, Feizhi Weng, Wei Sun, Yinglei Zhai, Zhou Li. Dual-functional chameleon microneedles based on Cel/Fe-GA-OKGM/Gel for programmed biofilm eradication and real-time healing surveillance in chronic wounds[J]. Journal of Zhejiang University Science D, 2026, 9(5): 979 - 1000.
@article{title="Dual-functional chameleon microneedles based on Cel/Fe-GA-OKGM/Gel for programmed biofilm eradication and real-time healing surveillance in chronic wounds",
author="Xi Pan, Qida Zong, Qianwen Zhang, Ruizeng Luo, Feizhi Weng, Wei Sun, Yinglei Zhai, Zhou Li",
journal="Journal of Zhejiang University Science D",
volume="9",
number="5",
pages="979 - 1000",
year="2026",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2500505"
}
%0 Journal Article
%T Dual-functional chameleon microneedles based on Cel/Fe-GA-OKGM/Gel for programmed biofilm eradication and real-time healing surveillance in chronic wounds
%A Xi Pan
%A Qida Zong
%A Qianwen Zhang
%A Ruizeng Luo
%A Feizhi Weng
%A Wei Sun
%A Yinglei Zhai
%A Zhou Li
%J Journal of Zhejiang University SCIENCE D
%V 9
%N 5
%P 979 - 1000
%@ 1869-1951
%D 2026
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2500505
TY - JOUR
T1 - Dual-functional chameleon microneedles based on Cel/Fe-GA-OKGM/Gel for programmed biofilm eradication and real-time healing surveillance in chronic wounds
A1 - Xi Pan
A1 - Qida Zong
A1 - Qianwen Zhang
A1 - Ruizeng Luo
A1 - Feizhi Weng
A1 - Wei Sun
A1 - Yinglei Zhai
A1 - Zhou Li
J0 - Journal of Zhejiang University Science D
VL - 9
IS - 5
SP - 979
EP - 1000
%@ 1869-1951
Y1 - 2026
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2500505
Abstract: Wound dressings play a critical role in wound management, yet engineering specialized solutions for biofilm-compromised chronic infections remains a formidable challenge. To address this, we developed a cellulase (Cel)-integrated hydrogel microneedle (MN) patch—comprising gallic acid (GA)-grafted oxidized konjac glucomannan (GA-OKGM), gelatin (Gel), and iron ions (denoted as Cel/Fe-GA-OKGM/Gel MNs)—for the programmed therapy and monitoring of chronic infected wounds. This hydrogel system features dual crosslinking via Fe-phenolic hydroxyl coordination bonds (GA-Fe) and Schiff base linkages (OKGM-Gel). By leveraging the physical penetration of MNs, surface-loaded cellulase efficiently degrades biofilms, thereby overcoming biofilm-mediated antimicrobial resistance. In vivo and in vitro studies demonstrate that these MNs exhibit potent biofilm-disrupting, antibacterial, anti-inflammatory, antioxidant, and macrophage-polarizing properties, collectively reprogramming the wound microenvironment to accelerate healing. Furthermore, the GA-Fe complex undergoes microenvironment-dependent chromatic transitions within wounds, serving as a real-time visual biomarker that dynamically reflects the progression of healing and infection status. This dual-functional “chameleon” system thus holds exceptional promise for the precise management of chronic infected wounds and future clinical translation.
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CLC number:
On-line Access: 2026-09-12
Received: 2025-10-04
Revision Accepted: 2026-02-09
Crosschecked: 0000-00-00
Cited:
Clicked: 43
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