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Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines
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MALLIKARJUNA B.P., SURESH KUMAR G.V., SASTRY B.S., NAGARAJ, MANOHARA K.P.. Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines[J]. Journal of Zhejiang University Science B, 2007, 8(7): 526-532.
@article{title="Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines",
author="MALLIKARJUNA B.P., SURESH KUMAR G.V., SASTRY B.S., NAGARAJ, MANOHARA K.P.",
journal="Journal of Zhejiang University Science B",
volume="8",
number="7",
pages="526-532",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0526"
}
%0 Journal Article
%T Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines
%A MALLIKARJUNA B.P.
%A SURESH KUMAR G.V.
%A SASTRY B.S.
%A NAGARAJ
%A MANOHARA K.P.
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 7
%P 526-532
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0526
TY - JOUR
T1 - Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines
A1 - MALLIKARJUNA B.P.
A1 - SURESH KUMAR G.V.
A1 - SASTRY B.S.
A1 - NAGARAJ
A1 - MANOHARA K.P.
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 7
SP - 526
EP - 532
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0526
Abstract: In the present research, a series of 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5,286-Bis aryl 1%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>6-Bis aryl 1,2,4-triazines 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5a~285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5f were synthesized by condensation of various benzils 4a~4f with aminoguanidine bicarbonate and were screened in vivo, for their anticonvulsant and neurotoxicity studies. Compounds 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5a, 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5b and 285%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>2f4a8b>5d were found to be potent molecules of this series, when compared with the reference drugs phenytoin sodium, diazepam and lamotrigine. The structures of these compounds were established by IR, 1H NMR, 13C NMR and mass spectroscopic data.
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