CLC number: R593.2
On-line Access: 2010-10-05
Received: 2010-03-11
Revision Accepted: 2010-07-05
Crosschecked: 2010-09-13
Cited: 0
Clicked: 5136
Xi Xie, Jin-wei Chen, Fen Li, Jing Tian, Jie-sheng Gao, David Zhang. Infliximab treatment in two Chinese patients with psoriatic arthritis[J]. Journal of Zhejiang University Science B, 2010, 11(10): 779-782.
@article{title="Infliximab treatment in two Chinese patients with psoriatic arthritis",
author="Xi Xie, Jin-wei Chen, Fen Li, Jing Tian, Jie-sheng Gao, David Zhang",
journal="Journal of Zhejiang University Science B",
volume="11",
number="10",
pages="779-782",
year="2010",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1000087"
}
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000087
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T1 - Infliximab treatment in two Chinese patients with psoriatic arthritis
A1 - Xi Xie
A1 - Jin-wei Chen
A1 - Fen Li
A1 - Jing Tian
A1 - Jie-sheng Gao
A1 - David Zhang
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 10
SP - 779
EP - 782
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000087
Abstract: Psoriatic arthritis (PsA) is a rheumatoid factor (RF)-seronegative systemic inflammatory disorder associated with psoriasis. Current treatment for PsA in China is still focused on disease modifying anti-rheumatic drugs (DMARDs). In this paper, we report two Chinese patients with active longstanding PsA treated with infliximab, a human-mouse chimeric monoclonal antibody against tumor necrosis factor alpha (TNF-α). The results show that infliximab acted quickly and effectively in relieving peripheral and axial symptoms and refractory skin lesions, even in recombinant human TNF-α receptor (rhTNFR)-resistant case. The take-home message from our cases is that infliximab is a useful therapeutic option for refractory PsA, especially when a patient has a combination of psoriasis and psoriatic arthritis. Further local evidence and experience must be accumulated in order to make anti-TNF-α therapy more accessible to PsA patients in China.
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