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On-line Access: 2010-10-05

Received: 2010-03-11

Revision Accepted: 2010-07-05

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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.10 P.779-782


Infliximab treatment in two Chinese patients with psoriatic arthritis

Author(s):  Xi Xie, Jin-wei Chen, Fen Li, Jing Tian, Jie-sheng Gao, David Zhang

Affiliation(s):  Department of Rheumatology, the Second Xiangya Hospital, Central South University, Changsha 410011, China; more

Corresponding email(s):   jinwei73104@yahoo.com.cn

Key Words:  Refractory psoriatic arthritis, Skin lesions, Infliximab, Anti-tumor necrosis factor alpha (TNF-α, ) treatment

Xi Xie, Jin-wei Chen, Fen Li, Jing Tian, Jie-sheng Gao, David Zhang. Infliximab treatment in two Chinese patients with psoriatic arthritis[J]. Journal of Zhejiang University Science B, 2010, 11(10): 779-782.

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T1 - Infliximab treatment in two Chinese patients with psoriatic arthritis
A1 - Xi Xie
A1 - Jin-wei Chen
A1 - Fen Li
A1 - Jing Tian
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A1 - David Zhang
J0 - Journal of Zhejiang University Science B
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1000087

Psoriatic arthritis (PsA) is a rheumatoid factor (RF)-seronegative systemic inflammatory disorder associated with psoriasis. Current treatment for PsA in China is still focused on disease modifying anti-rheumatic drugs (DMARDs). In this paper, we report two Chinese patients with active longstanding PsA treated with infliximab, a human-mouse chimeric monoclonal antibody against tumor necrosis factor alpha (TNF-α). The results show that infliximab acted quickly and effectively in relieving peripheral and axial symptoms and refractory skin lesions, even in recombinant human TNF-α receptor (rhTNFR)-resistant case. The take-home message from our cases is that infliximab is a useful therapeutic option for refractory PsA, especially when a patient has a combination of psoriasis and psoriatic arthritis. Further local evidence and experience must be accumulated in order to make anti-TNF-α therapy more accessible to PsA patients in China.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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