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Abstract: mandibular defect occurs more frequently in recent years, and clinical repair operations via bone transplantation are difficult to be further improved due to some intrinsic flaws. tissue engineering, which is a hot research field of biomedical engineering, provides a new direction for mandibular defect repair. As the basis and key part of tissue engineering, scaffolds have been widely and deeply studied in regards to the basic theory, as well as the principle of biomaterial, structure, design, and fabrication method. However, little research is targeted at tissue regeneration for clinic repair operations. Since mandibular bone has a special structure, rather than uniform and regular structure in existing studies, a methodology based on tissue engineering is proposed for mandibular defect repair in this paper. Key steps regarding scaffold digital design, such as external shape design and internal microstructure design directly based on triangular meshes are discussed in detail. By analyzing the theoretical model and the measured data from the test parts fabricated by rapid prototyping, the feasibility and effectiveness of the proposed methodology are properly verified. More works about mechanical and biological improvements need to be done to promote its clinical application in future.

[1]Abu-Serriah, M.M., Odell, E., Lock, C., Gillar, A., Ayoub, A.F., Fleming, R.H., 2004. Histological assessment of bioengineered new bone in repairing osteoperiosteal mandibular defects in sheep using recombinant human bone morphogenetic protein-7. Br. J. Oral Maxillofac. Surg., 42(5):410-418.

[2]Abu-Serriah, M.M., Ayoub, A., Wray, D., Milne, N., Carmichael, S., Boyd, J., 2006. Contour and volume assessment of repairing mandibular osteoperiosteal continuity defects in sheep using recombinant human osteogenic protein 1. J. Craniomaxillofac. Surg., 34(3):162-167.

[3]Adachi, T., Osako, Y., Tanaka, M., Hojo, M., Hollister, S.J., 2006. Framework for optimal design of porous scaffold microstructure by computational simulation of bone regeneration. Biomaterials, 27(21):3964-3972.

[4]Armillotta, A., Pelzer, R., 2008. Modeling of porous structures for rapid prototyping of tissue engineering scaffolds. Int. J. Adv. Manuf. Technol., 39(5-6):501-511.

[5]Ciocca, L., D′Crescenzio, F., Fantini, M., Scotti, R., 2009. CAD/CAM and rapid prototyped scaffold construction for bone regenerative medicine and surgical transfer of virtual planning: a pilot study. Comput. Med. Imaging Graph., 33(1):58-62.

[6]d′Anquino, R., de Rosa, A., Lanza, V., Tirino, V., Laino, L., Graziano, A., 2009. Human mandible bone defect repair by the grafting of dental pulp stem/progenitor cells and collagen sponge biocomplexes. Eur. Cell Mater., 18:75-83.

[7]Drosse, I., Volkmer, E., Capanna, R., D′Biase, P., Mutschler, W., Schieker, M., 2008. Tissue engineering for bone defect healing: an update on a multi-component approach. Injury, 39(S2):s9-s20.

[8]Fang, Z., Starly, B., Sun, W., 2005. Computer-aided characterization for effective mechanical properties of porous tissue scaffolds. Comput. Aided Des., 37(1):65-72.

[9]Gurtner, G.C., Werner, S., Barrandon, Y., Longaker, M.T., 2008. Wound repair and regeneration. Nature, 453(7193):314-321.

[10]Hollister, S.J., Cheng, Y.L., 2007. Computational design of tissue engineering scaffolds. Comput. Methods Appl. Mech. Eng., 196(31-32):2991-2998.

[11]Jiang, X.Q., Zhao, J., Wang, S.Y., Sun, X.J., Zhang, X.L., Chen, J., Kaplan, D.L., Zhang, Z.Y., 2009. Mandibular repair in rats with premineralized silk scaffolds and BMP-2-modified bMSCs. Biomaterials, 30(27):4522-4532.

[12]Langer, R., Vacanti, J.P., 1993. Tissue engineering. Science, 260(5110):920-926.

[13]Más Estellés, J., Vidaurre, A., Duenas, J.M.M., Cortázar, I.C., 2008. Physical characterization of polycaprolactone scaffolds. J. Mater. Sci. Mater. Med., 19(1):189-195.

[14]Sachlos, E., Czernuszka, J.T., 2003. Making tissue engineering scaffolds work. Review of the application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur. Cell Mater., 5:29-40.

[15]Sun, W., Lal, P., 2002. Recent development on computer aided tissue engineering—a review. Comput. Methods Programs Biomed., 67(2):85-103.

[16]Sun, W., Starly, B., Nam, J., Darling, A., 2005. Bio-CAD modeling and its applications in computer-aided tissue engineering. Comput. Aided Des., 37(11):1097-1114.

[17]Williams, J.M., Adewunmi, A., Schek, R.M., Flanagan, C.L., Krebsbach, P.H., Feinberg, S.E., Hollister, S.J., Das, S., 2005. Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering. Biomaterials, 26(23):4817-4827.

[18]Yuan, J., Cui, L., Zhang, W.J., Liu, W., Cao, Y.L., 2007. Repair of canine mandibular bone defects with bone marrow stromal cells and porous β-tricalcium phosphate. Biomaterials, 28(6):1005-1013.

[19]Zhao, J., Zhang, Z., Wang, S., Sun, X., Chen, J., Kaplan, D.L., Jiang, X., 2009. Apatite-coated silk fibroin scaffolds to healing mandibular border defects in canines. Bone, 45(3):517-527.