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Abstract: The recent article by Liang et al. (2011) , published in Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), is highly interesting. Interestingly, the past few years have seen the increasing application of berbamine as an anti-cancer agent in other systemic malignancies besides chronic myeloid leukemia.

[1]Cheng, Y.H., Qi, J., Xiong, D.S., Liu, J.W., Qi, S.L., Pan, B., Yang, C.Z., Zhu, H.F., 2006. Reversal of multidrug resistance in drug-resistant human breast cancer cell line MCF-7/ADR by calmodulin antagonist O-(4-ethoxyl-butyl)-berbamine. Acta Acad. Med. Sin., 28(2):164-168 (in Chinese).

[2]Du, H.P., Shen, J.K., Yang, M., Wang, Y.Q., Yuan, X.Q., Ma, Q.L., Jin, J., 2010. 4-Chlorobenzoyl berbamine induces apoptosis and G₂/M cell cycle arrest through the PI3K/Akt and NF-kappaB signal pathway in lymphoma cells. Oncol. Rep., 23(3):709-716.

[3]Duan, H., Luan, J., Liu, Q., Yagasaki, K., Zhang, G., 2010. Suppression of human lung cancer cell growth and migration by berbamine. Cytotechnology, 62(4):341-348.

[4]Liang, Y., Xu, R.Z., Zhang, L., Zhao, X.Y., 2009a. Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells. Acta Pharmacol. Sin., 30(12):1659-1665.

[5]Liang, Y., Zhao, X.Y., Wei, Y.L., Xu, R.Z., 2009b. Berbamine induces apoptosis of multiple myeloma RPMI 8226 cells by activating GADD45/JNK pathway. J. Zhejiang Univ. (Med. Sci.), 38(5):439-444 (in Chinese).

[6]Liang, Y., Qiu, X., Xu, R.Z., Zhao, X.Y., 2011. Berbamine inhibits proliferation and induces apoptosis of KU812 cells by increasing Smad3 activity. J. Zhejiang Univ.-Sci. B (Biomed. & Biotechnol.), 12(7):568-574.

[7]Liu, R., Zhang, Y., Chen, Y., Qi, J., Ren, S.M., Xushi, M.Y., Yang, C.Z., Zhu, H., Xiong, D.S., 2010. A novel calmodulin antagonist O-(4-ethoxyl-butyl)-berbamine overcomes multidrug resistance in drug-resistant MCF-7/ADR breast carcinoma cells. J. Pharm. Sci., 99(7):3266-3275.

[8]Wang, G.Y., Zhang, J.W., Lu, Q.H., Xu, R.Z., Dong, Q.H., 2007. Berbamine induces apoptosis in human hepatoma cell line SMMC7721 by loss in mitochondrial transmembrane potential and caspase activation. J. Zhejiang Univ.-Sci. B, 8(4):248-555.

[9]Wang, G.Y., Lv, Q.H., Dong, Q., Xu, R.Z., Dong, Q.H., 2009. Berbamine induces Fas-mediated apoptosis in human hepatocellular carcinoma HepG2 cells and inhibits its tumor growth in nude mice. J. Asian Nat. Prod. Res., 11(3):219-228.

[10]Wang, S., Liu, Q., Zhang, Y., Liu, K., Yu, P.F., Liu, K., Luan, J.L., Duan, H.Y., Lu, Z.Q., Wang, F.F., et al., 2009. Suppression of growth, migration and invasion of highly-metastatic human breast cancer cells by berbamine and its molecular mechanisms of action. Mol. Cancer, 8(1):81.