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Abstract: Coronavirus disease 2019 (COVID-19) is a global infectious disease that seriously endangers human life and health and affects normal social activities. Since the pandemic outbreak from December 2019 to February 2023, the total number of confirmed cases has exceeded 753 million, and the deaths caused by COVID-19 have reached 6.6 million (https://covid19.who.int; accessed on Feb. 16, 2023). Currently, supportive therapy is the primary treatment for patients, as some antiviral drugs have demonstrated significant side effects during clinical treatment. Although vaccination has a particular effect on the prevention of novel coronavirus infection and the emergence of severe diseases, the variation in the virus strain caused the vaccine�s protective effect to be greatly weakened or lost. Therefore, there is an urgent need to identify safe and effective drugs to prevent and cure COVID-19. Relevant research and exploration can also provide a reference for drug screening with which to address similar infectious diseases and public health events in the future.

羊栖菜来源的褐藻多糖硫酸酯调控人胚肺二倍体成纤维细胞中新冠病毒受体分子AXL的表达

[1]BarataPC, RiniBI, 2017. Treatment of renal cell carcinoma: current status and future directions. CA Cancer J Clin, 67(6):507-524.

[2]BéressA, WassermannO, BruhnT, et al., 1993. A new procedure for the isolation of anti-HIV compounds (polysaccharides and polyphenols) from the marine alga fucus vesiculosus. J Nat Prod, 56(4):478-488.

[3]BoehmerTK, DeViesJ, CarusoE, et al., 2020. Changing age distribution of the COVID-19 pandemic—‍United States, May‍–‍August 2020. MMWR Morb Mort Wkly Rep, 69(39):1404-1409.

[4]BuckCB, ThompsonCD, RobertsJN, et al., 2006. Carrageenan is a potent inhibitor of papillomavirus infection. PLoS Pathog, 2(7):e69.

[5]ChoiEM, KimAJ, KimYO, et al., 2005. Immunomodulating activity of arabinogalactan and fucoidan in vitro. J Med Food, 8(4):446-453.

[6]DamonteEB, MatulewiczMC, CerezoAS, 2004. Sulfated seaweed polysaccharides as antiviral agents. Curr Med Chem, 11(18):2399-2419.

[7]FeneyrollesC, SpenlinhauerA, GuietL, et al., 2014. Axl kinase as a key target for oncology: focus on small molecule inhibitors. Mol Cancer Ther, 13(9):2141-2148.

[8]HoshinoT, HayashiT, HayashiK, et al., 1998. An antivirally active sulfated polysaccharide from Sargassum horneri (TURNER) C.AGARDH. Biol Pharm Bull, 21(7):‍730-734.

[9]JinWH, TangH, ZhangJM, et al., 2020. Structural analysis of a novel sulfated galacto-fuco-xylo-glucurono-mannan from Sargassum fusiforme and its anti-lung cancer activity. Int J Biol Macromol, 149:450-458.

[10]LiJH, ZhangZY, TongTJ, 1995. The proliferative response and anti-oncogene expression in old 2BS cells after growth factor stimulation. Mech Ageing Dev, 80(1):25-34.

[11]LimS, ZhangM, ChangTL, 2022. ACE2-independent alternative receptors for SARS-CoV-2. Viruses, 14(11):2535.

[12]LukassenS, ChuaRL, TrefzerT, et al., 2020. SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells. EMBO J, 39(10):e105114.

[13]MaoGX, WangY, QiuQ, et al., 2010. Salidroside protects human fibroblast cells from premature senescence induced by H₂O₂ partly through modulating oxidative status. Mech Ageing Dev, 131(11-12):723-731.

[14]MoralesA, Rojo RelloS, CristóbalH, et al., 2021. Growth arrest-specific factor 6 (GAS6) is increased in COVID-19 patients and predicts clinical outcome. Biomedicines, 9(4):335.

[15]QueirozKCS, MedeirosVP, QueirozLS, et al., 2008. Inhibition of reverse transcriptase activity of HIV by polysaccharides of brown algae. Biomed Pharmacother, 62(5):303-307.

[16]ReyfmanPA, WalterJM, JoshiN, et al., 2019. Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis. Am J Respir Crit Care Med, 199(12):1517-1536.

[17]SungnakW, HuangN, BécavinC, et al., 2020. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med, 26(5):‍681-687.

[18]TangZ, ZhangZ, ZhengY, et al., 1994. Cell aging of human diploid fibroblasts is associated with changes in responsiveness to epidermal growth factor and changes in HER-2 expression. Mech Ageing Dev, 73(1):57-67.

[19]UndurragaEA, ChowellG, MizumotoK, 2021. COVID-19 case fatality risk by age and gender in a high testing setting in Latin America: Chile, March‍–‍August 2020. Inf Dis Poverty, 10:11.

[20]ValverdeP, 2005. Effects of Gas6 and hydrogen peroxide in Axl ubiquitination and downregulation. Biochem Biophys Res Commun, 333(1):180-185.

[21]WangS, QiuZY, HouYN, et al., 2021. AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. Cell Res, 31(2):‍‍126-140.

[22]WangSY, XuXG, SunC, et al., 2021. Sulphated glucuronomannan tetramer and hexamer from Sargassum thunbergii exhibit anti-human cytomegalovirus activity by blocking viral entry. Carbohyd Polym, 273:118510.