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Abstract: glufosinate-ammonium herbicides are the most widely used broad-spectrum, non-selective herbicides in the world. glufosinate-ammonium is a structural analogue of glutamate (Glu) which can irreversibly inhibit the activity of glutamine synthetase (GS) and Glu decarboxylase in plants, thereby blocking the synthesis of glutamine (Gln) from Glu and ammonia (Hoerlein, 1994). This causes the plants to die because of the nitrogen metabolism disorder and subsequent intracellular accumulation of ammonia. In humans, the characteristic features of glufosinate-ammonium herbicide poisoning include gastrointestinal symptoms and neurotoxicity (Watanabe and Sano, 1998). Currently, there are no antidotes for glufosinate-ammonium herbicide poisoning, and thus supportive care is the key treatment.

三例以癫痫为主要表现的急性草铵膦中毒患者的病例报告

[1]ChaYS,KimH,LeeY,et al.,2018.The relationship between serum ammonia level and neurologic complications in patients with acute glufosinate ammonium poisoning: a prospective observational study.Hum Exp Toxicol,37(6):571-579.

[2]HermenegildoC,MonfortP,FelipoV,2000.Activation ofN-methyl-D-aspartate receptors in rat brainin vivo following acute ammonia intoxication: characterization byin vivo brain microdialysis.Hepatology,31(3):709-715.

[3]HoerleinG,1994.Glufosinate (phosphinothricin), a natural amino acid with unexpected herbicidal properties. In: Ware GW (Ed.),Reviews of Environmental Contamination and Toxicology: Continuation of Residue Reviews.Springer,New York, p.73-145.

[4]HoriY,TanakaT,FujisawaM,et al.,2003.Toxicokinetics of DL-glufosinate enantiomer in human BASTA^® poisoning.Biol Pharm Bull,26(4):540-543.

[5]KimJ,ChunBJ,MoonJM,et al.,2022.Prognostic value of neutrophil to lymphocyte ratio in the diagnosis of neurotoxicity after glufosinate ammonium poisoning.J Toxicol Environ Health Part A,85(12):511-519.

[6]ParkS,KimDE,ParkSY,et al.,2018.Seizures in patients with acute pesticide intoxication, with a focus on glufosinate ammonium.Hum Exp Toxicol,37(4):331-337.

[7]ParkS,KimJI,ChoNJ,et al.,2020.Decreased glucose utilization contributes to memory impairment in patients with glufosinate ammonium intoxication.J Clin Med,9(4):1213.

[8]QinCF,YangYM,LuYQ,2023.Perforation of the esophagus: an overlooked cause of chest pain as a complication of esophageal foreign bodies.J Zhejiang Univ-Sci B (Biomed & Biotechnol),24(5):455-457.

[9]Rangroo ThraneV,ThraneAS,WangFS,et al.,2013.Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering.Nat Med,19(12):1643-1648.

[10]SongCY,LuYQ,2022.A man with fever and cogwheel-like dermal lesions.Int Emerg Med,17(8):2423-2425.

[11]SongHY,KimYH,SeokSJ,et al.,2012.Cellular toxicity of surfactants used as herbicide additives.J Korean Med Sci,27(1):3-9.

[12]TongT,DuanWX,XuYD,et al.,2022.Paraquat exposure induces Parkinsonism by altering lipid profile and evoking neuroinflammation in the midbrain.Environ Int,169:107512.

[13]WangP,SongCY,LuYQ,2022.Isolated superior mesenteric artery rupture caused by abdominal trauma.J Zhejiang Univ-Sci B (Biomed & Biotechnol),23(12):1065-1068.

[14]WangZD,LuX,YangYM,et al.,2023.Inflammatory granuloma of the trachea: a rare case with Epstin-Barr virus infection.J Zhejiang Univ-Sci B (Biomed & Biotechnol),24(6):539-542.

[15]WatanabeT,SanoT,1998.Neurological effects of glufosinate poisoning with a brief review.Hum Exp Toxicol,17(1):35-39.

[16]ZhouX,HollernD,LiaoJ,et al.,2013.NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors.Cell Death Dis,4(3):e560.