CLC number:
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 0000-00-00
Cited: 0
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Judith Synofzik, Sebastian Heene, Rebecca Jonczyk & Cornelia Blume. Ink-structing the future of vascular tissue engineering: a review of the physiological bioink design[J]. Journal of Zhejiang University Science D, 2024, 7(2): 181-205.
@article{title="Ink-structing the future of vascular tissue engineering: a review
of the physiological bioink design",
author="Judith Synofzik, Sebastian Heene, Rebecca Jonczyk & Cornelia Blume",
journal="Journal of Zhejiang University Science D",
volume="7",
number="2",
pages="181-205",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-024-00270-w"
}
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%A Judith Synofzik
%A Sebastian Heene
%A Rebecca Jonczyk & Cornelia Blume
%J Journal of Zhejiang University SCIENCE D
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%N 2
%P 181-205
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%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-024-00270-w
TY - JOUR
T1 - Ink-structing the future of vascular tissue engineering: a review
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A1 - Judith Synofzik
A1 - Sebastian Heene
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J0 - Journal of Zhejiang University Science D
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PB - Zhejiang University Press & Springer
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DOI - 10.1007/s42242-024-00270-w
Abstract: Three-dimensional (3D) printing and bioprinting have come into view for a plannable and standardizable generation of
implantable tissue-engineered constructs that can substitute native tissues and organs. These tissue-engineered structures are
intended to integrate with the patient’s body. Vascular tissue engineering (TE) is relevant in TE because it supports the sustained
oxygenization and nutrition of all tissue-engineered constructs. bioinks have a specific role, representing the necessary medium
for printability and vascular cell growth. This review aims to understand the requirements for the design of vascular bioinks.
First, an in-depth analysis of vascular cell interaction with their native environment must be gained. A physiological bioink
suitable for a tissue-engineered vascular graft (TEVG) must not only ensure good printability but also induce cells to behave
like in a native vascular vessel, including self-regenerative and growth functions. This review describes the general structure of
vascular walls with wall-specific cell and extracellular matrix (ECM) components and biomechanical properties and functions.
Furthermore, the physiological role of vascular ECM components for their interaction with vascular cells and the mode of
interaction is introduced. Diverse currently available or imaginable bioinks are described from physiological matrix proteins to
nonphysiologically occurring but natural chemical compounds useful for vascular bioprinting. The physiological performance
of these bioinks is evaluated with regard to biomechanical properties postprinting, with a view to current animal studies of
3D printed vascular structures. Finally, the main challenges for further bioink development, suitable bioink components to
create a self-assembly bioink concept, and future bioprinting strategies are outlined. These concepts are discussed in terms
of their suitability to be part of a TEVG with a high potential for later clinical use.
Open peer comments: Debate/Discuss/Question/Opinion
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