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Bio-Design and Manufacturing  2022 Vol.5 No.3 P.556-579

http://doi.org/10.1007/s42242-022-00182-7


Application of additively manufactured 3D scaffolds for bone cancer treatment: a review


Author(s):  Yanhao Hou, Weiguang Wang & Paulo Bartolo

Affiliation(s):  Department of Mechanical, Aerospace and Civil Engineering, School of Engineering, Faculty of Science and Engineering, The University of Manchester, Manchester M13 9PL, UK; more

Corresponding email(s):   weiguang.wang@manchester.ac.uk, paulojorge.dasilvabartolo@manchester.ac.uk, pbartolo@ntu.edu.sg

Key Words:  Additive manufacturing, Biomanufacturing, Bone cancer, Implants, Tissue engineering


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Yanhao Hou, Weiguang Wang & Paulo Bartolo. Application of additively manufactured 3D scaffolds for bone cancer treatment: a review[J]. Journal of Zhejiang University Science D, 2022, 5(3): 556-579.

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Abstract: 
bone cancer is a critical health problem on a global scale, and the associated huge clinical and economic burdens are still rising. Although many clinical approaches are currently used for bone cancer treatment, these methods usually affect the normal body functions and thus present significant limitations. Meanwhile, advanced materials and additive manufacturing have opened up promising avenues for the development of new strategies targeting both bone cancer treatment and post-treatment bone regeneration. This paper presents a comprehensive review of bone cancer and its current treatment methods, particularly focusing on a number of advanced strategies such as scaffolds based on advanced functional materials, drug-loaded scaffolds, and scaffolds for photothermal/magnetothermal therapy. Finally, the main research challenges and future perspectives are elaborated.

曼彻斯特大学Paulo Bartolo等 | 增材制造3D支架在骨癌治疗中的应用综述

本综述论文聚焦增材制造3D支架在骨癌治疗中的应用研究。骨癌是全球范围内的一个重大健康问题,随之而来的巨大临床和经济负担仍在上升。虽然目前有许多临床方法用于骨癌治疗,但这些方法通常影响正常的身体功能,因此存在显著的局限性。与此同时,先进材料和增材制造为开发针对骨癌治疗和治疗后骨再生的新策略开辟了广阔的途径。本文综述了骨癌及其现有治疗方法,特别关注基于先进功能材料的支架、载药支架、光热/磁热治疗支架等先进策略。最后,阐述了主要的研究挑战和未来前景。

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