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Bio-Design and Manufacturing  2024 Vol.7 No.5 P.670-686

http://doi.org/10.1007/s42242-024-00279-1


Enhanced wear resistance, antibacterial performance, and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro


Author(s):  Qingge Wang, Jia Liu, Hong Wu, Jingbo Liu, Yaojia Ren, Luxin Liang, Xinxin Yan, Ian Baker, Shifeng Liu, V. V. Uglov, Chengliang Yang, Liqiang Wang

Affiliation(s):  State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China; more

Corresponding email(s):   hwucsu@csu.edu.cn, wuhong927@126.com, stbyyl@126.com, wang_liqiang@sjtu.edu.cn

Key Words:  βTi alloy · Surface modification · Wear resistance · Corrosion resistance · Osteogenic behavior · Antibacterial activity


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Qingge Wang, Jia Liu, Hong Wu, Jingbo Liu, Yaojia Ren, Luxin Liang, Xinxin Yan, Ian Baker, Shifeng Liu, V. V. Uglov, Chengliang Yang, Liqiang Wang. Enhanced wear resistance, antibacterial performance, and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro[J]. Journal of Zhejiang University Science D, 2024, 7(5): 670-686.

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Abstract: 
A good Ti-based joint implant should prevent stress shielding and achieve good bioactivity and anti-infection performance. To meet these requirements, the low-elastic-modulus alloy—Ti–35Nb–2Ta–3Zr—was used as the substrate, and functional coatings that contained bioceramics and Ag ions were prepared for coating on TiO2 nanotubes (diameter: (80±20) nm and (150±40) nm) using anodization, deposition, and spin-coating methods. The effects of the bioceramics (nano-β-tricalcium phosphate, microhydroxyapatite (micro-HA), and meso-CaSiO3) and Ag nanoparticles (size: (50±20) nm) on the antibacterial activity and the tribocorrosion, corrosion, and early in vitro osteogenic behaviors of the nanotubes were investigated. The tribocorrosion and corrosion results showed that the wear rate and corrosive rate were highly dependent on the features of the nanotube surface. Micro-HA showed great wear resistance with a wear rate of (1.26±0.06)×10−3 mm3/(N·m) due to adhesive and abrasive wear. Meso-CaSiO3 showed enhanced cell adhesion, proliferation, and alkaline phosphatase activity. The coatings that contained nano-Ag exhibited good antibacterial activity with an antibacterial rate of ≥89.5% against Escherichia coli. These findings indicate that hybrid coatings may have the potential to accelerate osteogenesis.

中南大学吴宏上海交通大学王立强团队 | 利用含有纳米银和生物陶瓷的纳米管提升耐磨性、抗菌性能和体外生物相容性

本研究论文结合多种表面改性技术在低模量钛合金表面构建功能复合改性层,利用含有纳米银和生物陶瓷的纳米管提升耐磨性、抗菌性能和体外生物相容性。理想的钛基关节植入物应避免应力屏蔽, 且具有良好的生物活性和抗感染性能。为满足这些要求, 研究人员以低弹性模量合金Ti–35Nb–2Ta–3Zr为基体, 采用阳极氧化、沉积和旋涂等方法制备含有生物陶瓷和银离子的功能涂层, 并将其涂覆在TiO2纳米管 ((80 ± 20) nm 和(150 ± 40) nm) 表面。研究了生物陶瓷 (nano-β-TCP, micro-HA, meso-CaSiO3) 和Ag纳米颗粒 ((50 ± 20) nm) 对纳米管的抗菌活性、摩擦、腐蚀和早期体外成骨行为的影响。摩擦和腐蚀结果表明, 磨损率和腐蚀速率与纳米管表面形貌密切相关。由于黏着磨损和磨粒磨损, 生物陶瓷micro-HA 表现出优异的耐磨性, 磨损率为(1.26 ± 0.06)×10–3 mm3/(N m)。生物陶瓷meso-CaSiO3显示出良好的细胞黏附、增殖能力和碱性磷酸酶活性。含有纳米银的涂层具有良好的抗菌活性, 对大肠杆菌的抗菌率 ≥ 89.5%。研究结果表明, 该功能涂层具有促进成骨的潜力。

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