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Mg2+ containing composite scaffolds mediate macrophage polarization to enhance meniscus regeneration
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Zong Li, Weili Shi, Ming Tian, Wenqiang Yan, Yifei Fan, Jin Cheng, Xiaoqing Hu, Xi Gong, Yingfang Ao. Mg2+ containing composite scaffolds mediate macrophage polarization to enhance meniscus regeneration[J]. Journal of Zhejiang University Science D, 2016, -1(-1): .
@article{title="Mg2+ containing composite scaffolds mediate macrophage
polarization to enhance meniscus regeneration",
author="Zong Li, Weili Shi, Ming Tian, Wenqiang Yan, Yifei Fan, Jin Cheng, Xiaoqing Hu, Xi Gong, Yingfang Ao",
journal="Journal of Zhejiang University Science D",
volume="-1",
number="-1",
pages="",
year="2016",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400313"
}
%0 Journal Article
%T Mg2+ containing composite scaffolds mediate macrophage
polarization to enhance meniscus regeneration
%A Zong Li
%A Weili Shi
%A Ming Tian
%A Wenqiang Yan
%A Yifei Fan
%A Jin Cheng
%A Xiaoqing Hu
%A Xi Gong
%A Yingfang Ao
%J Journal of Zhejiang University SCIENCE D
%V -1
%N -1
%P
%@ 1869-1951
%D 2016
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400313
TY - JOUR
T1 - Mg2+ containing composite scaffolds mediate macrophage
polarization to enhance meniscus regeneration
A1 - Zong Li
A1 - Weili Shi
A1 - Ming Tian
A1 - Wenqiang Yan
A1 - Yifei Fan
A1 - Jin Cheng
A1 - Xiaoqing Hu
A1 - Xi Gong
A1 - Yingfang Ao
J0 - Journal of Zhejiang University Science D
VL - -1
IS - -1
SP -
EP -
%@ 1869-1951
Y1 - 2016
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400313
Abstract: Meniscal injury, a prevalent and challenging medical condition, is characterized by
poor self-healing potential and a complex microenvironment. Tissue engineering
scaffolds, particularly those made of silk fibroin (SF)/hyaluronic acid methacryloy
(HAMA) and encapsulating Mg2+, are promising options for meniscal repair. However,
the inflammatory response following implantation is a significant concern. In this
study, we prepared a composite SF/HAMA-Mg hydrogel scaffold, evaluated its
physical and chemical properties, and detected its fibrochondrogenic differentiation
effect in vitro and the healing effect in a rabbit meniscus defect model in vivo. Our
results showed that the scaffold differentiates pro-inflammatory M1 macrophages into
anti-inflammatory M2 macrophages after implantation, thereby reducing
inflammation and facilitating the growth and repair of meniscus tissue. Further, the
composite scaffold provided a conducive milieu for cell proliferation, anticipatory
differentiation, and generation of extracellular matrix. In summary, composite
SF/HAMA-Mg scaffolds display exceptional biocompatibility, anti-inflammatory
properties, and superior potential for meniscus repair.
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