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On-line Access: 2025-09-19
Received: 2024-09-02
Revision Accepted: 2025-03-23
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Evaluation of the 3D printable temperature-responsive shape-memory PLTG terpolymers for minimally invasive surgery
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Xulin Hu (胡旭麟), Jun Wang (王均), Shuhao Yang (杨舒皓), Jun Deng (邓俊), Wanyue Feng (冯万月), Haoming Wu (邬浩明), Dongdong Han (韩冬冬), Leilei Qin (秦磊磊), Jianye Yang (杨建业), Zhengguang Pu (蒲正广), Xin Yong (雍鑫), Yanlin Li (李彦林), Shuai Li (李帅) & Ning Hu (胡宁). Evaluation of the 3D printable temperature-responsive shape-memory PLTG terpolymers for minimally invasive surgery[J]. Journal of Zhejiang University Science D, 2025, 8(5): 709-723.
@article{title="Evaluation of the 3D printable temperature-responsive shape-memory PLTG
terpolymers for minimally invasive surgery",
author="Xulin Hu (胡旭麟), Jun Wang (王均), Shuhao Yang (杨舒皓), Jun Deng (邓俊), Wanyue Feng (冯万月), Haoming Wu (邬浩明), Dongdong Han (韩冬冬), Leilei Qin (秦磊磊), Jianye Yang (杨建业), Zhengguang Pu (蒲正广), Xin Yong (雍鑫), Yanlin Li (李彦林), Shuai Li (李帅) & Ning Hu (胡宁)",
journal="Journal of Zhejiang University Science D",
volume="8",
number="5",
pages="709-723",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400486"
}
%0 Journal Article
%T Evaluation of the 3D printable temperature-responsive shape-memory PLTG
terpolymers for minimally invasive surgery
%A Xulin Hu (胡旭麟)
%A Jun Wang (王均)
%A Shuhao Yang (杨舒皓)
%A Jun Deng (邓俊)
%A Wanyue Feng (冯万月)
%A Haoming Wu (邬浩明)
%A Dongdong Han (韩冬冬)
%A Leilei Qin (秦磊磊)
%A Jianye Yang (杨建业)
%A Zhengguang Pu (蒲正广)
%A Xin Yong (雍鑫)
%A Yanlin Li (李彦林)
%A Shuai Li (李帅) & Ning Hu (胡宁)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 5
%P 709-723
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400486
TY - JOUR
T1 - Evaluation of the 3D printable temperature-responsive shape-memory PLTG
terpolymers for minimally invasive surgery
A1 - Xulin Hu (胡旭麟)
A1 - Jun Wang (王均)
A1 - Shuhao Yang (杨舒皓)
A1 - Jun Deng (邓俊)
A1 - Wanyue Feng (冯万月)
A1 - Haoming Wu (邬浩明)
A1 - Dongdong Han (韩冬冬)
A1 - Leilei Qin (秦磊磊)
A1 - Jianye Yang (杨建业)
A1 - Zhengguang Pu (蒲正广)
A1 - Xin Yong (雍鑫)
A1 - Yanlin Li (李彦林)
A1 - Shuai Li (李帅) & Ning Hu (胡宁)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 5
SP - 709
EP - 723
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400486
Abstract: Three-dimensional (3D) printing has revolutionized the design and production of customized scaffolds, but the minimally in
vasive implantation of 3D-printed structures into the human body remains challenging. This has prompted the exploration of
innovative materials and technical solutions. Shape-memory polymers, as advanced intelligent materials, exhibit considerable
potential in minimally invasive surgical applications. Herein, we developed a novel thermosetting shape-memory polymer,
poly(L-lactic acid)-trimethylene carbonate-glycolic acid (PLLA-TMC-GA), for the fabrication of bioengineered scaffolds with
body temperature-activated shape-memory functionality. We comprehensively evaluated the mechanical properties, thermal
stability, shape-memory capabilities, biocompatibility, biodegradability, and 3D printing performance of PLLA-TMC-GA
terpolymers with various compositions. The results indicate that PLLA-TMC-GA exhibits exceptional shape-memory perfor
mance, adjustable material properties, favorable biocompatibility, and the potential for controlled biodegradation and reab
sorption. The use of PLLA-TMC-GA as a biodegradable shape-memory polymer allows the reduction of implant volume,
simplifies implantation, and enables on-demand activation at body temperature. These characteristics present new opportuni
ties for the advancement of minimally invasive surgical techniques.
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