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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2022-09-16
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BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation
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Mengdan YU, Qianwei ZHAO, Jinxia LI, Fang XU, Zhibiao ZHANG, Yixian LIU, Liping DAI, Bingxia ZHANG, Jianying ZHANG, Jintao ZHANG. BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation[J]. Journal of Zhejiang University Science B, 2022, 23(9): 760-769.
@article{title="BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation",
author="Mengdan YU, Qianwei ZHAO, Jinxia LI, Fang XU, Zhibiao ZHANG, Yixian LIU, Liping DAI, Bingxia ZHANG, Jianying ZHANG, Jintao ZHANG",
journal="Journal of Zhejiang University Science B",
volume="23",
number="9",
pages="760-769",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2100985"
}
%0 Journal Article
%T BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation
%A Mengdan YU
%A Qianwei ZHAO
%A Jinxia LI
%A Fang XU
%A Zhibiao ZHANG
%A Yixian LIU
%A Liping DAI
%A Bingxia ZHANG
%A Jianying ZHANG
%A Jintao ZHANG
%J Journal of Zhejiang University SCIENCE B
%V 23
%N 9
%P 760-769
%@ 1673-1581
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100985
TY - JOUR
T1 - BCAT1 promotes lung adenocarcinoma progression through enhanced mitochondrial function and NF-κB pathway activation
A1 - Mengdan YU
A1 - Qianwei ZHAO
A1 - Jinxia LI
A1 - Fang XU
A1 - Zhibiao ZHANG
A1 - Yixian LIU
A1 - Liping DAI
A1 - Bingxia ZHANG
A1 - Jianying ZHANG
A1 - Jintao ZHANG
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 9
SP - 760
EP - 769
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2100985
Abstract: Lung cancer is one of the most prevalent and malignant cancers, among which lung adenocarcinoma (LUAD) accounts for the majority and remains a major cause of cancer-related mortality worldwide (
[1]AnanievaEA, WilkinsonAC, 2018. Branched-chain amino acid metabolism in cancer. Curr Opin Clin Nutr Metab Care, 21(1):64-70.
[2]ChenLP, LiQ, ZhengZW, et al., 2019. Design and optimize N-substituted EF24 as effective and low toxicity NF-κB inhibitor for lung cancer therapy via apoptosis-to-pyroptosis switch. Chem Biol Drug Des, 94(1):1368-1377.
[3]CuiYM, FangWF, LiCF, et al., 2019. Development and validation of a novel signature to predict overall survival in “driver gene-negative” lung adenocarcinoma (LUAD): results of a multicenter study. Clin Cancer Res, 25(5):1546-1556.
[4]FuSJ, LiZ, XiaoLB, et al., 2019. Glutamine synthetase promotes radiation resistance via facilitating nucleotide metabolism and subsequent DNA damage repair. Cell Rep, 28(5):1136-1143.E4.
[5]KoJH, OlonaA, PapathanassiuAE, et al., 2020. BCAT1 affects mitochondrial metabolism independently of leucine transamination in activated human macrophages. J Cell Sci, 133(22):jcs247957.
[6]LinXM, TanST, FuL, et al., 2020. BCAT1 overexpression promotes proliferation, invasion, and Wnt signaling in non-small cell lung cancers. Onco Targets Ther, 13:3583-3594.
[7]LoukiliN, Rosenblatt-VelinN, RolliJ, et al., 2010. Oxidants positively or negatively regulate nuclear factor κB in a context-dependent manner. J Biol Chem, 285(21):15746-15752.
[8]LuoJ, YaoY, JiSG, et al., 2019. PITX2 enhances progression of lung adenocarcinoma by transcriptionally regulating WNT3A and activating Wnt/β-catenin signaling pathway. Cancer Cell Int, 19:96.
[9]MorganMJ, LiuZG, 2011. Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res, 21(1):103-115.
[10]OktyabriD, IshimuraA, TangeS, et al., 2016. DOT1L histone methyltransferase regulates the expression of BCAT1 and is involved in sphere formation and cell migration of breast cancer cell lines. Biochimie, 123:20-31.
[11]RaiAK, JaiswaN, MauryaCK, et al., 2019. Fructose-induced AGEs-RAGE signaling in skeletal muscle contributes to impairment of glucose homeostasis. J Nutr Biochem, 71:35-44.
[12]ShamekhiS, AbdolalizadehJ, OstadrahimiA, et al., 2020. Apoptotic effect of Saccharomyces cerevisiae on human colon cancer SW480 cells by regulation of Akt/NF-κB signaling pathway. Probiotics Antimicrob Proteins, 12(1):311-319.
[13]TyagiM, PatroBS, 2019. Salinomycin reduces growth, proliferation and metastasis of cisplatin resistant breast cancer cells via NF-κB deregulation. Toxicol in Vitro, 60:125-133.
[14]XuY, YuWM, YangTT, et al., 2018. Overexpression of BCAT1 is a prognostic marker in gastric cancer. Hum Pathol, 75:41-46.
[15]ZhangJQ, SunGY, MeiXD, et al., 2019. Elevated FAM83A expression predicts poorer clincal outcome in lung adenocarcinoma. Cancer Biomark, 26(3):367-373.
[16]ZhangJX, WangXL, VikashV, et al., 2016. ROS and ROS-mediated cellular signaling. Oxid Med Cell Longev, 2016:4350965.
[17]ZhangL, HanJQ, 2017. Branched-chain amino acid transaminase 1 (BCAT1) promotes the growth of breast cancer cells through improving mTOR-mediated mitochondrial biogenesis and function. Biochem Biophys Res Commun, 486(2):224-231.
[18]ZhouLS, DongCS, XuZM, et al., 2021. NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis. J Zhejiang Univ-Sci B (Biomed & Biotechnol), 22(11):959-965.
[19]ZhuWJ, ShaoYQ, PengY, 2017. MicroRNA-218 inhibits tumor growth and increases chemosensitivity to CDDP treatment by targeting BCAT1 in prostate cancer. Mol Carcinog, 56(6):1570-1577.
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