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Abstract: food allergy (FA) is a global health problem that affects a large population, and thus effective treatment is highly desirable. oral immunotherapy (OIT) has been showing reasonable efficacy and favorable safety in most FA subjects. Dependable biomarkers are needed for treatment assessment and outcome prediction during OIT. Several immunological indicators have been used as biomarkers in OIT, such as skin prick tests, basophil and mast cell reactivity, T cell and B cell responses, allergen-specific antibody levels, and cytokines. Other novel indicators also could be potential biomarkers. In this review, we discuss and assess the application of various immunological indicators as biomarkers for OIT.

口服免疫治疗中的生物标志物

朱海涛¹，唐开发²，陈国强¹，刘仲伟^3
1西北妇女儿童医院儿内三科，中国西安，710061
²贵州医科大学附属医院泌尿外科，中国贵阳，550004
³陕西省人民医院心血管内科，中国西安，710068
概要：食物过敏（food allergy，FA）是影响大量人口的全球健康问题之一，因此非常需要有效的治疗。口服免疫治疗（oral immunotherapy，OIT）在大多数FA受试者中显示出良好的疗效和安全性。OIT期间需要可靠的生物标志物进行治疗评估和结果预测。多种免疫学指标已被用作OIT的生物标志物，例如皮肤点刺试验、嗜碱性粒细胞和肥大细胞反应性、T细胞和B细胞应答反应、过敏原特异性抗体水平和细胞因子等。其他新的指标也可作为潜在的生物标志物。本文讨论并评估了各种免疫相关指标作为OIT生物标志物的应用。

关键词：食物过敏；口服免疫治疗；生物标记物；免疫耐受；脱敏

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