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Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases
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Qihui ZHOU, Panpan CEN, Zhi CHEN, Jie JIN. Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases",
author="Qihui ZHOU, Panpan CEN, Zhi CHEN, Jie JIN",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
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year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2400053"
}
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%T Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases
%A Qihui ZHOU
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%J Journal of Zhejiang University SCIENCE B
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%@ 1673-1581
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2400053
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DOI - 10.1631/jzus.B2400053
Abstract: Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an intracellular transcription factor that helps protect against oxidative stress in different types of cells under pathological conditions. Mitochondria are vital organelles functioning in diverse metabolic processes in the body, including redox reactions, lipid metabolism and cell death. mitophagy, a specific form of autophagy for damaged mitochondria, plays a critical role in the pathophysiology of liver diseases. In this review we explain in detail the roles of the nrf2 signaling pathway and mitophagy, and the relationship between them, in various hepatic diseases (nonalcoholic fatty liver disease, viral hepatitis, alcoholic liver disease, drug-induced liver injury, autoimmune hepatitis, hepatic ischemia–reperfusion injury and liver cancer). We also offer some potential insights and treatments relevant to clinical applications.
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