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Abstract: Nuclear factor erythroid 2-related factor 2 (Nrf2) is an intracellular transcription factor that helps protect against oxidative stress in different types of cells under pathological conditions. Mitochondria are vital organelles that function in diverse metabolic processes in the body, including redox reactions, lipid metabolism, and cell death. mitophagy, a specific form of autophagy for damaged mitochondria, plays a critical role in the pathophysiology of liver diseases. In this review, we explain in detail the roles of the nrf2 signaling pathway and mitophagy, and the relationship between them, in various hepatic diseases (nonalcoholic fatty liver disease, viral hepatitis, alcoholic liver disease, drug-induced liver injury, autoimmune hepatitis, hepatic ischemia‒reperfusion injury, and liver cancer). We also offer some potential insights and treatments relevant to clinical applications.

Keap1/Nrf2通路和线粒体自噬在肝脏疾病中的作用

周琦惠¹，岑盼盼¹，陈智²，金洁^1
1西湖大学医学院附属杭州市第一人民医院感染性疾病科，中国杭州市，310006
²浙江大学医学院附属第一医院感染性疾病科，传染病诊治国家重点实验，国家传染病临床研究中心，传染病诊治协同创新中心，中国杭州市，310003
摘要：核因子E2相关因子2（Nrf2）是一种细胞内转录因子，在病理条件下有助于保护不同类型细胞免受氧化应激。线粒体参与机体内多种代谢过程，包括氧化还原反应、脂质代谢和细胞死亡等。线粒体自噬是自噬的一种特殊形式，专门负责清除受损的线粒体，在肝脏疾病病理生理机制中起着重要作用。本综述详细阐述了Nrf2信号通路和线粒体自噬在各种肝脏疾病（非酒精性脂肪性肝病、病毒性肝炎、酒精性肝病、药物性肝损伤、自身免疫性肝炎、肝缺血再灌注损伤和肝癌）中的作用及其相互关系，同时提供了一些临床应用相关的潜在见解和治疗方法。

关键词：Nrf2信号通路；细胞自噬；肝脏疾病

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