CLC number: R965
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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FENG Zhou-yan, ZHENG Xiao-xiang. The effect of Jujuboside A on the evoked field potentials of granule cells in dentate gyrus[J]. Journal of Zhejiang University Science A, 2002, 3(5): 591-593.
@article{title="The effect of Jujuboside A on the evoked field potentials of granule cells in dentate gyrus",
author="FENG Zhou-yan, ZHENG Xiao-xiang",
journal="Journal of Zhejiang University Science A",
volume="3",
number="5",
pages="591-593",
year="2002",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2002.0591"
}
%0 Journal Article
%T The effect of Jujuboside A on the evoked field potentials of granule cells in dentate gyrus
%A FENG Zhou-yan
%A ZHENG Xiao-xiang
%J Journal of Zhejiang University SCIENCE A
%V 3
%N 5
%P 591-593
%@ 1869-1951
%D 2002
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2002.0591
TY - JOUR
T1 - The effect of Jujuboside A on the evoked field potentials of granule cells in dentate gyrus
A1 - FENG Zhou-yan
A1 - ZHENG Xiao-xiang
J0 - Journal of Zhejiang University Science A
VL - 3
IS - 5
SP - 591
EP - 593
%@ 1869-1951
Y1 - 2002
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2002.0591
Abstract: Jujuboside A (JuA) is a main component of Jujubogenin extracted from the seeds of Ziziphus. The authors have not seen any report on JuA's direct effect on the neurons of the central nervous system. This study aimed to assess the effect of JuA on paired-pulse responses of dentate gyrus granule cells in urethane-anaesthetized rats, used intracerebroventricular (i.c.v.) JuA to mimic in vitro bath conditions in vivo. Paired-pulse stimuli with 80 ms interpulse interval were used to stimulate the perforant pathway. Evoked responses were recorded in the dentate gyrus cell layer after i.c.v. administration of 0.9% normal saline or JuA. In the first responses, the slopes of excitatory postsynaptic potential (EPSP1) and the amplitudes of population spike (PS1) decreased significantly after administration of JuA while the PS1 latencies increased significantly. In the second responses, the EPSP2 slopes and PS2 latencies were changed similarly to those of the first ones, but PS2 amplitudes increased. The results showed that JuA may have some inhibitory effect on the granule cell excitability mediated by presynaptic mechanism but may have little effect on the excitability mediated by postsynaptic mechanism since the second evoked N-methyl-D-aspartic mediating paired-pulse facilitation is a postsynaptic mechanism.
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