Full Text:   <2661>

CLC number: R573

On-line Access: 

Received: 2002-11-01

Revision Accepted: 2003-05-19

Crosschecked: 0000-00-00

Cited: 4

Clicked: 5137

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE A 2004 Vol.5 No.2 P.242-245

http://doi.org/10.1631/jzus.2004.0242


Distribution of H. pylori antigens in gastric mucosa and its significance


Author(s):  LU Xin-liang, QIAN Ke-da, TANG Xun-qiu, ZHU Yong-liang

Affiliation(s):  Department of Gastroenterology, the Second Affiliated Hospital, clollege of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   xl_lu@hotmail.com.cn

Key Words:  Helicobacter pylori, Immunohistochemistry, Antigen, Gastric cancer, Precancerous change


Share this article to: More

LU Xin-liang, QIAN Ke-da, TANG Xun-qiu, ZHU Yong-liang. Distribution of H. pylori antigens in gastric mucosa and its significance[J]. Journal of Zhejiang University Science A, 2004, 5(2): 242-245.

@article{title="Distribution of H. pylori antigens in gastric mucosa and its significance",
author="LU Xin-liang, QIAN Ke-da, TANG Xun-qiu, ZHU Yong-liang",
journal="Journal of Zhejiang University Science A",
volume="5",
number="2",
pages="242-245",
year="2004",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2004.0242"
}

%0 Journal Article
%T Distribution of H. pylori antigens in gastric mucosa and its significance
%A LU Xin-liang
%A QIAN Ke-da
%A TANG Xun-qiu
%A ZHU Yong-liang
%J Journal of Zhejiang University SCIENCE A
%V 5
%N 2
%P 242-245
%@ 1869-1951
%D 2004
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2004.0242

TY - JOUR
T1 - Distribution of H. pylori antigens in gastric mucosa and its significance
A1 - LU Xin-liang
A1 - QIAN Ke-da
A1 - TANG Xun-qiu
A1 - ZHU Yong-liang
J0 - Journal of Zhejiang University Science A
VL - 5
IS - 2
SP - 242
EP - 245
%@ 1869-1951
Y1 - 2004
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2004.0242


Abstract: 
Objective: To investigate the distribution of H. pylori antigens in the gastric mucosa in patients with H. pylori infection, and the relationship between the distribution and gastric cancer. Methods: Of 112 patients confirmed by pathological study to have chronic superficial gastritis, precancerous changes (chronic atrophic gastritis, intestinal metaplasia or atypical hyperplasia) and gastric cancer, 28 were H. pylori negative and 84 were H. pyloripositive. H. pylori antigens in the gastric mucosa were detected by immunohistochemistry. Results: The H.pylori positive group, comprised 12 of 22 (50.0%) in the chronic superficial gastritis group, 22 of 25 (88.0%) in the precancerous changes group and 13 of 35 (37.1%) in the gastric cancer group. The positive rates of H. pylori antigens in the cytoplasm progressively increased, respectively at 0.0% (0/12), 63.6% (14/22) and 84.6% (11/13) for the same groups (χ²=19.76, P=0.000); H. pylori antigens were located in the mucus layer and above the neck of the mucosal gland in 9 of 12 (75.0%) cases with chronic superficial gastritis, at the neck of the mucosal gland and the isthmus in 12 of 22 (54.5%) cases with precancerous changes, below the isthmus in 9 of 13 (69.2%) cases with gastric cancer (χ²=25.30, P=0.000). In the H.pylori negative group, no H. pylori antigen was observed. Conclusion: With the progression of chronic superficial gastritis→precancerous changes→gastric cancer, H. pylori antigens progressively migrated from the outer part to the inner part of the cell, and from the superficial to the deep gastric mucosa.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Cerutti, P.A., 1994. Oxy-radicals and cancer.Lancet,344(8926):862-863.

[2] Davies, G.R., Simmonds, N.J., Stevens, T.R., Sheaff, M.T., Banatvala, N., Laurenson, I.F., Blake, D.R., Rampton, D.S., 1994.Helicobater pyloristimulates antral mucosal reactive oxygen metabolite production in vivo.Gut,35(2):179-185.

[3] Engstrand, L., Graham, D., Scheynius, A., Genta, R.M., El-Zaatari, F., 1997. Is the sanctuary whereHelicobacter pyloriavoids antibacterial treatment intracellularAm J Clin Pathol,108(5):504-509.

[4] Ernst, P., 1999. Review article: the role of inflammation in the pathogenesis of gastric cancer.Aliment Pharmacol Ther,13(Suppl 1):13-18.

[5] Ko, G.H., Kang, S.M., Kim, Y.K., Lee, J.H., Park, C.K., Youn, H.S., Baik, S.C., Cho, M.J., Lee, W.K., Rhee, K.H., 1999. Invasiveness of Helicobacter pylori intohuman gastric mucosa.Helicobacter,4(2):77-81.

[6] Watanabe, T., Tada, M., Nagai, H., Sasaki, S., Nakao, M., 1998.Helicobacter pyloriinfection induces gastric cancer in Mongolian gerbils.Gastroenterology,115(3):642-648.

[7] Yang, Y., Deng, C.S., Yao, X.J., Liu, H.Y., Chen, M., 2000. Electron microscopic observation after interaction betweenHelicobacter pyloriand gastric epithelial cells.Chinese Journal of Internal Medicine,39(7):454-456 (in Chinese).

[8] Yu, D.H., Ye, H.P., Wang, P., Yao, M., Ding, R.P., 1997. Relationship betweenHelicobacter pyloriL-form and Gastric Malignant Neoplasm.Chinese Journal of Zoonoses,13(1):7-9(in Chinese).

[9] Zheng, P.Y., Tang, F.A., Hua, J.S., Ho, B., Duan, F.L., 1999. Study on the dimorphism ofHelicobacter pylori.Chinese Journal of Digestion, 19(4):230-232(in Chinese).

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE