CLC number:
On-line Access: 2023-01-11
Received: 2022-11-28
Revision Accepted: 2022-12-13
Crosschecked: 2023-01-13
Cited: 0
Clicked: 31087
Citations: Bibtex RefMan EndNote GB/T7714
Deng-ke ZHAO, He-qi XU, Jun YIN, Hua-yong YANG. Inkjet 3D bioprinting for tissue engineering and pharmaceutics[J]. Journal of Zhejiang University Science A, 2022, 23(12): 955-973.
@article{title="Inkjet 3D bioprinting for tissue engineering and pharmaceutics",
author="Deng-ke ZHAO, He-qi XU, Jun YIN, Hua-yong YANG",
journal="Journal of Zhejiang University Science A",
volume="23",
number="12",
pages="955-973",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.A2200569"
}
%0 Journal Article
%T Inkjet 3D bioprinting for tissue engineering and pharmaceutics
%A Deng-ke ZHAO
%A He-qi XU
%A Jun YIN
%A Hua-yong YANG
%J Journal of Zhejiang University SCIENCE A
%V 23
%N 12
%P 955-973
%@ 1673-565X
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.A2200569
TY - JOUR
T1 - Inkjet 3D bioprinting for tissue engineering and pharmaceutics
A1 - Deng-ke ZHAO
A1 - He-qi XU
A1 - Jun YIN
A1 - Hua-yong YANG
J0 - Journal of Zhejiang University Science A
VL - 23
IS - 12
SP - 955
EP - 973
%@ 1673-565X
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.A2200569
Abstract: 3D bioprinting has the capability to create 3D cellular constructs with the desired shape using a layer-by-layer approach. inkjet 3D bioprinting, as a key component of 3D bioprinting, relies on the deposition of cell-laden droplets to create native-like tissues/organs which are envisioned to be transplantable into human body for replacing damaged ones. Benefiting from its superiorities such as high printing resolution and deposition accuracy, inkjet 3D bioprinting has been widely applied to various areas, including, but not limited to, tissue engineering and drug screening in pharmaceutics. Even though inkjet 3D bioprinting has proved its feasibility and versatility in various fields, the current applications of inkjet 3D bioprinting are still limited by the printing technique and material selection. This review, which specifically focuses on inkjet 3D bioprinting, firstly summarizes the techniques, materials, and applications of inkjet 3D bioprinting in tissue engineering and drug screening, subsequently discusses the major challenges that inkjet 3D bioprinting is facing, and lastly summarizes potential solutions to those challenges.
[1]AlbannaM, BinderKW, MurphySV, et al., 2019. In situ bioprinting of autologous skin cells accelerates wound healing of extensive excisional full-thickness wounds. Scientific Reports, 9(1):1856.
[2]ArrabitoG, PignataroB, 2010. Inkjet printing methodologies for drug screening. Analytical Chemistry, 82(8):3104-3107.
[3]BasaranOA, GaoHJ, BhatPP, 2013. Nonstandard inkjets. Annual Review of Fluid Mechanics, 45:85-113.
[4]BedellML, TorresAL, HoganKJ, et al., 2022. Human gelatin-based composite hydrogels for osteochondral tissue engineering and their adaptation into bioinks for extrusion, inkjet, and digital light processing bioprinting. Biofabrication, 14(4):045012.
[5]BlaeserA, Duarte CamposDF, PusterU, et al., 2016. Controlling shear stress in 3D bioprinting is a key factor to balance printing resolution and stem cell integrity. Advanced Healthcare Materials, 5(3):326-333.
[6]CaiSX, SunYL, WangZ, et al., 2021. Mechanisms, influencing factors, and applications of electrohydrodynamic jet printing. Nanotechnology Reviews, 10(1):1046-1078.
[7]CampbellA, MohlJE, GutierrezDA, et al., 2020. Thermal bioprinting causes ample alterations of expression of LUCAT1, IL6, CCL26, and NRN1L genes and massive phosphorylation of critical oncogenic drug resistance pathways in breast cancer cells. Frontiers in Bioengineering and Biotechnology, 8:82.
[8]ChenEP, ToksoyZ, DavisBA, et al., 2021. 3D bioprinting of vascularized tissues for in vitro and in vivo applications. Frontiers in Bioengineering and Biotechnology, 9:664188.
[9]ChristensenK, XuCX, ChaiWX, et al., 2015. Freeform inkjet printing of cellular structures with bifurcations. Biotechnology and Bioengineering, 112(5):1047-1055.
[10]CooperGM, MillerED, DeCesareGE, et al., 2010. Inkjet-based biopatterning of bone morphogenetic protein-2 to spatially control calvarial bone formation. Tissue Engineering Part A, 16(5):1749-1759.
[11]CuiXF, BolandT, 2009. Human microvasculature fabrication using thermal inkjet printing technology. Biomaterials, 30(31):6221-6227.
[12]CuiXF, BolandT, D’LimaDD, et al., 2012. Thermal inkjet printing in tissue engineering and regenerative medicine. Recent Patents on Drug Delivery & Formulation, 6(2):149-155.
[13]DerbyB, 2010. Inkjet printing of functional and structural materials: fluid property requirements, feature stability, and resolution. Annual Review of Materials Research, 40:395-414.
[14]DerbyB, 2012. Printing and prototyping of tissues and scaffolds. Science, 338(6109):921-926.
[15]Duarte CamposDF, RohdeM, RossM, et al., 2019. Corneal bioprinting utilizing collagen-based bioinks and primary human keratocytes. Journal of Biomedical Materials Research Part A, 107(9):1945-1953.
[16]DufourA, GallostraXB, O’KeeffeC, et al., 2022. Integrating melt electrowriting and inkjet bioprinting for engineering structurally organized articular cartilage. Biomaterials, 283:121405.
[17]EggersJ, VillermauxE, 2008. Physics of liquid jets. Reports on Progress in Physics, 71(3):036601.
[18]Faulkner-JonesA, FyfeC, CornelissenDJ, et al., 2015. Bioprinting of human pluripotent stem cells and their directed differentiation into hepatocyte-like cells for the generation of mini-livers in 3D. Biofabrication, 7(4):044102.
[19]FreemanFE, PitaccoP, van DommelenLHA, et al., 2020. 3D bioprinting spatiotemporally defined patterns of growth factors to tightly control tissue regeneration. Science Advances, 6(33):eabb5093.
[20]GaoDJ, ZhouJG, 2019. Designs and applications of electrohydrodynamic 3D printing. International Journal of Bioprinting, 5(1):172.
[21]GaoGF, YonezawaT, HubbellK, et al., 2015. Inkjet‐bioprinted acrylated peptides and PEG hydrogel with human mesenchymal stem cells promote robust bone and cartilage formation with minimal printhead clogging. Biotechnology Journal, 10(10):1568-1577.
[22]GasperiniL, ManiglioD, MottaA, et al., 2015. An electrohydrodynamic bioprinter for alginate hydrogels containing living cells. Tissue Engineering Part C: Methods, 21(2):123-132.
[23]GodlemanJ, LerouxF, ReynoldsS, et al., 2021. Aromatic poly (fluorocarbinol)s: soluble, hydrophobic binders for inkjet formulations. Progress in Organic Coatings, 158:106378.
[24]GriffithLG, WuB, CimaMJ, et al., 1997. In vitro organogenesis of liver tissue. Annals of the New York Academy of Sciences, 831(1):382-397.
[25]GudapatiH, OzbolatIT, 2020. The role of concentration on drop formation and breakup of collagen, fibrinogen, and thrombin solutions during inkjet bioprinting. Langmuir, 36(50):15373-15385.
[26]GudapatiH, DeyM, OzbolatI, 2016. A comprehensive review on droplet-based bioprinting: past, present and future. Biomaterials, 102:20-42.
[27]GurkanUA, El AssalR, YildizSE, et al., 2014. Engineering anisotropic biomimetic fibrocartilage microenvironment by bioprinting mesenchymal stem cells in nanoliter gel droplets. Molecular Pharmaceutics, 11(7):2151-2159.
[28]GuvendirenM, MoldeJ, SoaresRMD, et al., 2016. Designing biomaterials for 3D printing. ACS Biomaterials Science & Engineering, 2(10):1679-1693.
[29]HeY, NieJ, XieM, et al., 2020. Why choose 3D bioprinting? Part III: printing in vitro 3D models for drug screening. Bio-Design and Manufacturing, 3:160-163.
[30]HerranCL, HuangY, 2012. Alginate microsphere fabrication using bipolar wave-based drop-on-demand jetting. Journal of Manufacturing Processes, 14(2):98-106.
[31]HerranCL, CoutrisN, 2013. Drop-on-demand for aqueous solutions of sodium alginate. Experiments in Fluids, 54(6):1548.
[32]HoathSD, 2016. Fundamentals of Inkjet Printing: the Science of Inkjet and Droplets. John Wiley & Sons, Weinheim, Germany.
[33]HoppB, SmauszT, SzabóG, et al., 2012. Femtosecond laser printing of living cells using absorbing film-assisted laser-induced forward transfer. Optical Engineering, 51(1):014302.
[34]JungMS, SkhinasJN, DuEY, et al., 2022. A high-throughput 3D bioprinted cancer cell migration and invasion model with versatile and broad biological applicability. Biomaterials Science, 10(20):5876-5887.
[35]KangD, ParkJA, KimW, et al., 2021. All‐inkjet‐printed 3D alveolar barrier model with physiologically relevant microarchitecture. Advanced Science, 8(10):2004990.
[36]KimYK, ParkJA, YoonWH, et al., 2016. Drop-on-demand inkjet-based cell printing with 30-μm nozzle diameter for cell-level accuracy. Biomicrofluidics, 10(6):064110.
[37]KlebeRJ, 1988. Cytoscribing: a method for micropositioning cells and the construction of two-and three-dimensional synthetic tissues. Experimental Cell Research, 179(2):362-373.
[38]KnowltonS, OnalS, YuCH, et al., 2015. Bioprinting for cancer research. Trends in Biotechnology, 33(9):504-513.
[39]KumarP, EbbensS, ZhaoXB, 2021. Inkjet printing of mammalian cells–theory and applications. Bioprinting, 23:e00157.
[40]KwonKS, RahmanMK, PhungTH, et al., 2020. Review of digital printing technologies for electronic materials. Flexible and Printed Electronics, 5(4):043003.
[41]LeeBK, YunYH, ChoiJS, et al., 2012. Fabrication of drug-loaded polymer microparticles with arbitrary geometries using a piezoelectric inkjet printing system. International Journal of Pharmaceutics, 427(2):305-310.
[42]LeeW, DebasitisJC, LeeVK, et al., 2009. Multi-layered culture of human skin fibroblasts and keratinocytes through three-dimensional freeform fabrication. Biomaterials, 30(8):1587-1595.
[43]LevatoR, JungstT, ScheuringRG, et al., 2020. From shape to function: the next step in bioprinting. Advanced Materials, 32(12):1906423.
[44]LiHY, LiuJK, LiK, et al., 2019. Piezoelectric micro-jet devices: a review. Sensors and Actuators A: Physical, 297:111552.
[45]LiXD, LiuBX, PeiB, et al., 2020. Inkjet bioprinting of biomaterials. Chemical Reviews, 120(19):10793-10833.
[46]LimJH, KukK, ShinSJ, et al., 2005. Failure mechanisms in thermal inkjet printhead analyzed by experiments and numerical simulation. Microelectronics Reliability, 45(3-4):473-478.
[47]LiuJC, ShahriarM, XuHQ, et al., 2022. Cell-laden bioink circulation-assisted inkjet-based bioprinting to mitigate cell sedimentation and aggregation. Biofabrication, 14(4):045020.
[48]LiuWJ, HeinrichMA, ZhouYX, et al., 2017. Extrusion bioprinting of shear‐thinning gelatin methacryloyl bioinks. Advanced Healthcare Materials, 6(12):1601451.
[49]MaL, LiYT, WuYT, et al., 2020. The construction of in vitro tumor models based on 3D bioprinting. Bio-Design and Manufacturing, 3(3):227-236.
[50]MaXY, LiuJ, ZhuW, et al., 2018. 3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling. Advanced Drug Delivery Reviews, 132:235-251.
[51]MandryckyC, WangZJ, KimK, et al., 2016. 3D bioprinting for engineering complex tissues. Biotechnology Advances, 34(4):422-434.
[52]MatsusakiM, SakaueK, KadowakiK, et al., 2013. Three‐dimensional human tissue chips fabricated by rapid and automatic inkjet cell printing. Advanced Healthcare Materials, 2(4):534-539.
[53]MironovV, BolandT, TruskT, et al., 2003. Organ printing: computer-aided jet-based 3D tissue engineering. Trends in Biotechnology, 21(4):157-161.
[54]MkhizeN, BhaskaranH, 2022. Electrohydrodynamic jet printing: introductory concepts and considerations. Small Science, 2(2):2100073.
[55]MoroniL, BurdickJA, HighleyC, et al., 2018. Biofabrication strategies for 3D in vitro models and regenerative medicine. Nature Reviews Materials, 3(5):21-37.
[56]MurphySV, AtalaA, 2014. 3D bioprinting of tissues and organs. Nature Biotechnology, 32(8):773-785.
[57]NakamuraM, KobayashiA, TakagiF, et al., 2005. Biocompatible inkjet printing technique for designed seeding of individual living cells. Tissue Engineering, 11(11-12):1658-1666.
[58]NakamuraM, IwanagaS, HenmiC, et al., 2010. Biomatrices and biomaterials for future developments of bioprinting and biofabrication. Biofabrication, 2(1):014110.
[59]NgWL, LeeJM, YeongWY, et al., 2017. Microvalve-based bioprinting–process, bio-inks and applications. Biomaterials Science, 5(4):632-647.
[60]NgWL, HuangX, ShkolnikovV, et al., 2022. Controlling droplet impact velocity and droplet volume: key factors to achieving high cell viability in sub-nanoliter droplet-based bioprinting. International Journal of Bioprinting, 8(1):424.
[61]NishiyamaY, HenmiC, IwanagaS, et al., 2008. Ink jet three-dimensional digital fabrication for biological tissue manufacturing: analysis of alginate microgel beads produced by ink jet droplets for three dimensional tissue fabrication. Journal of Imaging Science and Technology, 52(6):060201.
[62]NishiyamaY, NakamuraM, HenmiC, et al., 2009. Development of a three-dimensional bioprinter: construction of cell supporting structures using hydrogel and state-of-the-art inkjet technology. Journal of Biomechanical Engineering, 131(3):035001.
[63]PengWJ, DattaP, AyanB, et al., 2017. 3D bioprinting for drug discovery and development in pharmaceutics. Acta Biomaterialia, 57:26-46.
[64]PepelanovaI, KruppaK, ScheperT, et al., 2018. Gelatin-methacryloyl (GelMA) hydrogels with defined degree of functionalization as a versatile toolkit for 3D cell culture and extrusion bioprinting. Bioengineering, 5(3):55.
[65]PhungTH, KwonKS, 2022. Improved continuous inkjet for selective area coating using high‐viscosity insulating inks. Advanced Engineering Materials, 24(8):2101527.
[66]PoellmannMJ, BartonKL, MishraS, et al., 2011. Patterned hydrogel substrates for cell culture with electrohydrodynamic jet printing. Macromolecular Bioscience, 11(9):1164-1168.
[67]RamezaniH, ZhouLY, ShaoL, et al., 2020. Coaxial 3D bioprinting of organ prototyps from nutrients delivery to vascularization. Journal of Zhejiang University-SCIENCE A (Applied Physics & Engineering), 21(11):859-875.
[68]Rodríguez-DévoraJI, ZhangBM, ReynaD, et al., 2012. High throughput miniature drug-screening platform using bioprinting technology. Biofabrication, 4(3):035001.
[69]SantoniS, GugliandoloSG, SponchioniM, et al., 2022. 3D bioprinting: current status and trends—a guide to the literature and industrial practice. Bio-Design and Manufacturing, 5(1):14-42.
[70]ScoutarisN, ChaiF, MaurelB, et al., 2016. Development and biological evaluation of inkjet printed drug coatings on intravascular stent. Molecular Pharmaceutics, 13(1):125-133.
[71]ShahMA, LeeDG, LeeBY, et al., 2021. Classifications and applications of inkjet printing technology: a review. IEEE Access, 9:140079-140102.
[72]ShapiraA, DvirT, 2021. 3D tissue and organ printing—hope and reality. Advanced Science, 8(10):2003751.
[73]ShiJ, WuB, LiSH, et al., 2018. Shear stress analysis and its effects on cell viability and cell proliferation in drop-on-demand bioprinting. Biomedical Physics & Engineering Express, 4(4):045028.
[74]SuntornnondR, NgWL, HuangX, et al., 2022. Improving printability of hydrogel-based bio-inks for thermal inkjet bioprinting applications via saponification and heat treatment processes. Journal of Materials Chemistry B, 10(31):5989-6000.
[75]TakagiD, LinWK, MatsumotoT, et al., 2019. High-precision three-dimensional inkjet technology for live cell bioprinting. International Journal of Bioprinting, 5(2):208.
[76]TalbotEL, BersonA, BrownPS, et al., 2012. Evaporation of picoliter droplets on surfaces with a range of wettabilities and thermal conductivities. Physical Review E, 85(6):061604.
[77]TaymourR, Chicaiza-CabezasNA, GelinskyM, et al., 2022. Core–shell bioprinting of vascularized in vitro liver sinusoid models. Biofabrication, 14(4):045019.
[78]TirellaA, VozziF, de MariaC, et al., 2011. Substrate stiffness influences high resolution printing of living cells with an ink-jet system. Journal of Bioscience and Bioengineering, 112(1):79-85.
[79]TsaiP, HendrixMHW, DijkstraRRM, et al., 2011. Microscopic structure influencing macroscopic splash at high weber number. Soft Matter, 7(24):11325-11333.
[80]TseC, WhiteleyR, YuT, et al., 2016. Inkjet printing Schwann cells and neuronal analogue NG108-15 cells. Biofabrication, 8:015017.
[81]UnagollaJM, JayasuriyaAC, 2020. Hydrogel-based 3D bioprinting: a comprehensive review on cell-laden hydrogels, bioink formulations, and future perspectives. Applied Materials Today, 18:100479.
[82]WijshoffH, 2010. The dynamics of the piezo inkjet printhead operation. Physics Reports, 491(4-5):77-177.
[83]WorkmanVL, TezeraLB, ElkingtonPT, et al., 2014. Controlled generation of microspheres incorporating extracellular matrix fibrils for three‐dimensional cell culture. Advanced Functional Materials, 24(18):2648-2657.
[84]WuDZ, XuCX, 2018. Predictive modeling of droplet formation processes in inkjet-based bioprinting. Journal of Manufacturing Science and Engineering, 140(10):101007.
[85]XieMJ, GaoQ, FuJZ, et al., 2020. Bioprinting of novel 3D tumor array chip for drug screening. Bio-Design and Manufacturing, 3(3):175-188.
[86]XuCX, ChaiWX, HuangY, et al., 2012. Scaffold‐free inkjet printing of three‐dimensional zigzag cellular tubes. Biotechnology and Bioengineering, 109(12):3152-3160.
[87]XuCX, ZhangZY, ChristensenK, et al., 2014. Freeform vertical and horizontal fabrication of alginate-based vascular-like tubular constructs using inkjetting. Journal of Manufacturing Science and Engineering, 136(6):061020.
[88]XuHQ, LiuJC, ZhangZY, et al., 2022a. Cell sedimentation during 3D bioprinting: a mini review. Bio-Design and Manufacturing, 5(3):617-626.
[89]XuHQ, Martinez SalazarDM, XuCX, 2022b. Investigation of cell concentration change and cell aggregation due to cell sedimentation during inkjet-based bioprinting of cell-laden bioink. Machines, 10(5):315.
[90]XuT, JinJ, GregoryC, et al., 2005. Inkjet printing of viable mammalian cells. Biomaterials, 26(1):93-99.
[91]XuT, RohozinskiJ, ZhaoWX, et al., 2009. Inkjet-mediated gene transfection into living cells combined with targeted delivery. Tissue Engineering Part A, 15(1):95-101.
[92]XuT, BinderKW, AlbannaMZ, et al., 2012. Hybrid printing of mechanically and biologically improved constructs for cartilage tissue engineering applications. Biofabrication, 5(1):015001.
[93]XuT, ZhaoWX, ZhuJM, et al., 2013. Complex heterogeneous tissue constructs containing multiple cell types prepared by inkjet printing technology. Biomaterials, 34(1):130-139.
[94]YangJX, ZhengF, DerbyB, 2021. Stability of lines with zero receding contact angle produced by inkjet printing at small drop volume. Langmuir, 37(1):26-34.
[95]YarinAL, 2006. Drop impact dynamics: splashing, spreading, receding, bouncing…. Annual Review of Fluid Mechanics, 38:159-192.
[96]YinJ, ZhaoDK, LiuJY, 2019. Trends on physical understanding of bioink printability. Bio-Design and Manufacturing, 2(1):50-54.
[97]YumotoM, HemmiN, SatoN, et al., 2020. Evaluation of the effects of cell-dispensing using an inkjet-based bioprinter on cell integrity by RNA-seq analysis. Scientific Reports, 10(1):7158.
[98]ZhangB, HeJK, LiX, et al., 2016. Micro/nanoscale electrohydrodynamic printing: from 2D to 3D. Nanoscale, 8(34):15376-15388.
[99]ZhangB, GaoL, MaL, et al., 2019. 3D bioprinting: a novel avenue for manufacturing tissues and organs. Engineering, 5(4):777-794.
[100]ZhangYS, KhademhosseiniA, 2020. Engineering in vitro human tissue models through bio-design and manufacturing. Bio-Design and Manufacturing, 3:155-159.
[101]ZhaoDK, ZhouHZ, WangYF, et al., 2021. Drop-on-demand (DOD) inkjet dynamics of printing viscoelastic conductive ink. Additive Manufacturing, 48:102451.
[102]ZhouHZ, LiuP, GaoZQ, et al., 2022. Simultaneous multimaterial multimethod bioprinting. Bio-Design and Manufacturing, 5:433-436.
[103]ZhuW, MaXY, GouML, et al., 2016. 3D printing of functional biomaterials for tissue engineering. Current Opinion in Biotechnology, 40:103-112.
Open peer comments: Debate/Discuss/Question/Opinion
<1>