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CLC number: R782.12

On-line Access: 2012-05-04

Received: 2011-12-21

Revision Accepted: 2012-03-27

Crosschecked: 2012-04-18

Cited: 25

Clicked: 5303

Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.5 P.364-371


Fluorescence microscopic analysis of bone osseointegration of strontium-substituted hydroxyapatite implants

Author(s):  Dan-li Fu, Qiao-hong Jiang, Fu-ming He, Guo-li Yang, Li Liu

Affiliation(s):  Department of General Dentistry, Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China; more

Corresponding email(s):   liuli0529@yahoo.com.cn

Key Words:  Strontium-substituted hydroxyapatite, Hydroxyapatite, Osseointegration

Dan-li Fu, Qiao-hong Jiang, Fu-ming He, Guo-li Yang, Li Liu. Fluorescence microscopic analysis of bone osseointegration of strontium-substituted hydroxyapatite implants[J]. Journal of Zhejiang University Science B, 2012, 13(5): 364-371.

@article{title="Fluorescence microscopic analysis of bone osseointegration of strontium-substituted hydroxyapatite implants",
author="Dan-li Fu, Qiao-hong Jiang, Fu-ming He, Guo-li Yang, Li Liu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Fluorescence microscopic analysis of bone osseointegration of strontium-substituted hydroxyapatite implants
%A Dan-li Fu
%A Qiao-hong Jiang
%A Fu-ming He
%A Guo-li Yang
%A Li Liu
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 5
%P 364-371
%@ 1673-1581
%D 2012
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1100381

T1 - Fluorescence microscopic analysis of bone osseointegration of strontium-substituted hydroxyapatite implants
A1 - Dan-li Fu
A1 - Qiao-hong Jiang
A1 - Fu-ming He
A1 - Guo-li Yang
A1 - Li Liu
J0 - Journal of Zhejiang University Science B
VL - 13
IS - 5
SP - 364
EP - 371
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1100381

The purpose of this study was to analyze the effect of hydroxyapatite%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>strontium-substituted hydroxyapatite (Sr-HA) on bone osseointegration of the implants using fluorescence microscopy. We allocated 20 implants to two groups: Sr-HA group and HA group. Electrochemically deposited HA and Sr-HA coatings were applied onto the implants separately. All the implants were inserted into femur bone of rabbits. Oxytetracycline hydrochloride, alizarin-complexon, and calcein green were respectively administered 7, 28, and 46 d after the implantation. After eight weeks, femurs were retrieved and prepared for the fluorescence microscopy observation. We analyzed the bone mineral apposition rates (MARs), bone area ratios (BARs), and bone to implant contact (BIC) of the two groups. Fluorescence microscopic observation showed that all groups exhibited extensive early peri-implant bone formation. The MAR of the Sr-HA group was greater than that for pure HA from 7 to 28 d after implantation, but no significant difference was found at later stage. And the BIC showed difference at 7 and 28 d compared with pure HA. We concluded that Sr-HA coating can improve the bone osseointegration of the implant in the early stage compared with the HA coating.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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