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CLC number: R782.05

On-line Access: 2013-06-04

Received: 2012-11-24

Revision Accepted: 2013-01-17

Crosschecked: 2013-05-10

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.6 P.518-525


Effects of zinc-substituted nano-hydroxyapatite coatings on bone integration with implant surfaces

Author(s):  Shi-fang Zhao, Wen-jing Dong, Qiao-hong Jiang, Fu-ming He, Xiao-xiang Wang, Guo-li Yang

Affiliation(s):  Department of Oral Implantology, Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China

Corresponding email(s):   guo_li1977@yahoo.cn

Key Words:  Zinc, Hydroxyapatite coating, Electrochemical process, Osseointegration, Implant

Shi-fang Zhao, Wen-jing Dong, Qiao-hong Jiang, Fu-ming He, Xiao-xiang Wang, Guo-li Yang. Effects of zinc-substituted nano-hydroxyapatite coatings on bone integration with implant surfaces[J]. Journal of Zhejiang University Science B, 2013, 14(6): 518-525.

@article{title="Effects of zinc-substituted nano-hydroxyapatite coatings on bone integration with implant surfaces",
author="Shi-fang Zhao, Wen-jing Dong, Qiao-hong Jiang, Fu-ming He, Xiao-xiang Wang, Guo-li Yang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effects of zinc-substituted nano-hydroxyapatite coatings on bone integration with implant surfaces
%A Shi-fang Zhao
%A Wen-jing Dong
%A Qiao-hong Jiang
%A Fu-ming He
%A Xiao-xiang Wang
%A Guo-li Yang
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 6
%P 518-525
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200327

T1 - Effects of zinc-substituted nano-hydroxyapatite coatings on bone integration with implant surfaces
A1 - Shi-fang Zhao
A1 - Wen-jing Dong
A1 - Qiao-hong Jiang
A1 - Fu-ming He
A1 - Xiao-xiang Wang
A1 - Guo-li Yang
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 6
SP - 518
EP - 525
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200327

Objective: The purpose of this study was to investigate the effects of a zinc-substituted nano-hydroxyapatite (Zn-HA) coating, applied by an electrochemical process, on implant osseointegraton in a rabbit model. Methods: A Zn-HA coating or an HA coating was deposited using an electrochemical process. Surface morphology was examined using field-emission scanning electron microscopy. The crystal structure and chemical composition of the coatings were examined using an X-ray diffractometer (XRD) and Fourier transform infrared spectroscopy (FTIR). A total of 78 implants were inserted into femurs and tibias of rabbits. After two, four, and eight weeks, femurs and tibias were retrieved and prepared for histomorphometric evaluation and removal torque (RTQ) tests. Results: Rod-like HA crystals appeared on both implant surfaces. The dimensions of the Zn-HA crystals seemed to be smaller than those of HA. XRD patterns showed that the peaks of both coatings matched well with standard HA patterns. FTIR spectra showed that both coatings consisted of HA crystals. The Zn-HA coating significantly improved the bone area within all threads after four and eight weeks (P<0.05), the bone to implant contact (BIC) at four weeks (P<0.05), and RTQ values after four and eight weeks (P<0.05). Conclusions: The study showed that an electrochemically deposited Zn-HA coating has potential for improving bone integration with an implant surface.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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