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CLC number: R962

On-line Access: 2013-11-04

Received: 2013-05-13

Revision Accepted: 2013-09-06

Crosschecked: 2013-10-15

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Journal of Zhejiang University SCIENCE B 2013 Vol.14 No.11 P.1004-1012


Neuroprotective effects of flavonoids extracted from licorice on kainate-induced seizure in mice through their antioxidant properties

Author(s):  Ling-hui Zeng, Hua-dan Zhang, Cai-ju Xu, Yu-jia Bian, Xue-jiao Xu, Qiang-min Xie, Rong-hua Zhang

Affiliation(s):  Department of Pharmacy, Zhejiang University City College, Hangzhou 310015, China; more

Corresponding email(s):   rhzhang@cdc.zj.cn

Key Words:  Seizure, Kainate, Flavonoid, Licorice, Antioxidant, Malondialdehyde (MDA), Superoxide dismutase (SOD)

Ling-hui Zeng, Hua-dan Zhang, Cai-ju Xu, Yu-jia Bian, Xue-jiao Xu, Qiang-min Xie, Rong-hua Zhang. Neuroprotective effects of flavonoids extracted from licorice on kainate-induced seizure in mice through their antioxidant properties[J]. Journal of Zhejiang University Science B, 2013, 14(11): 1004-1012.

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author="Ling-hui Zeng, Hua-dan Zhang, Cai-ju Xu, Yu-jia Bian, Xue-jiao Xu, Qiang-min Xie, Rong-hua Zhang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Neuroprotective effects of flavonoids extracted from licorice on kainate-induced seizure in mice through their antioxidant properties
%A Ling-hui Zeng
%A Hua-dan Zhang
%A Cai-ju Xu
%A Yu-jia Bian
%A Xue-jiao Xu
%A Qiang-min Xie
%A Rong-hua Zhang
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 11
%P 1004-1012
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300138

T1 - Neuroprotective effects of flavonoids extracted from licorice on kainate-induced seizure in mice through their antioxidant properties
A1 - Ling-hui Zeng
A1 - Hua-dan Zhang
A1 - Cai-ju Xu
A1 - Yu-jia Bian
A1 - Xue-jiao Xu
A1 - Qiang-min Xie
A1 - Rong-hua Zhang
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 11
SP - 1004
EP - 1012
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300138

A relationship between status epilepticus (SE) and oxidative stress has recently begun to be recognized. To explore whether the flavonoids extracted from licorice (LFs) have any protective effect on kainate (KA)-induced seizure in mice, we treated mice with LFs before and after KA injection. In KA-treated mice, we found that superoxide dismutase (SOD) activity decreased immediately after the onset of seizure at 1 h and then increased at 6 h. It returned to baseline 1 d after seizure and then increased again at 3, 7, and 28 d, while malondialdehyde (MDA) content remained at a high level at 1 h, 6 h, 3 d, 7 d, and 28 d, indicating a more oxidized status related to the presence of more reactive oxygen species (ROS). Treatment with LFs before KA injection reversed the seizure-induced change in SOD activity and MDA content at 1 h, 6 h, 3 d, 7 d, and 28 d. Treatment with LFs after seizure decreased KA-induced SOD activity and MDA content at 7 and 28 d. Also, LF pre- and post-KA treatments decreased seizure-induced neuronal cell death. Subsequently, Morris water maze tests revealed that the escape latency was significantly decreased and the number of target quadrant crossings was markedly increased in the LF-treated groups. Thus, our data indicate that LFs have protective effects on seizure-induced neuronal cell death and cognitive impairment through their anti-oxidative effects.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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