CLC number: R55
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2015-08-17
Cited: 6
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Ji-min Shi, Xu-ying Pei, Yi Luo, Ya-min Tan, Ru-xiu Tie, Jing-song He, Wei-yan Zheng, Jie Zhang, Zhen Cai, Mao-fang Lin, He Huang. Invasive fungal infection in allogeneic hematopoietic stem cell transplant recipients: single center experiences of 12 years[J]. Journal of Zhejiang University Science B, 2015, 16(9): 796-804.
@article{title="Invasive fungal infection in allogeneic hematopoietic stem cell transplant recipients: single center experiences of 12 years",
author="Ji-min Shi, Xu-ying Pei, Yi Luo, Ya-min Tan, Ru-xiu Tie, Jing-song He, Wei-yan Zheng, Jie Zhang, Zhen Cai, Mao-fang Lin, He Huang",
journal="Journal of Zhejiang University Science B",
volume="16",
number="9",
pages="796-804",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1500005"
}
%0 Journal Article
%T Invasive fungal infection in allogeneic hematopoietic stem cell transplant recipients: single center experiences of 12 years
%A Ji-min Shi
%A Xu-ying Pei
%A Yi Luo
%A Ya-min Tan
%A Ru-xiu Tie
%A Jing-song He
%A Wei-yan Zheng
%A Jie Zhang
%A Zhen Cai
%A Mao-fang Lin
%A He Huang
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 9
%P 796-804
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1500005
TY - JOUR
T1 - Invasive fungal infection in allogeneic hematopoietic stem cell transplant recipients: single center experiences of 12 years
A1 - Ji-min Shi
A1 - Xu-ying Pei
A1 - Yi Luo
A1 - Ya-min Tan
A1 - Ru-xiu Tie
A1 - Jing-song He
A1 - Wei-yan Zheng
A1 - Jie Zhang
A1 - Zhen Cai
A1 - Mao-fang Lin
A1 - He Huang
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 9
SP - 796
EP - 804
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1500005
Abstract: invasive fungal infection (IFI) is a growing cause of morbidity and mortality among patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). We retrospectively reviewed the records of 408 patients undergoing allo-HSCTs during the period November 1998 to December 2009, analyzed the incidence and risk factors of IFI, and examined the impact of IFI on overall survival. A total of 92 (22.5%) episodes suffered proven or probable IFI (4 patients were proven, 88 patients were probable). Candida was the most common pathogen for early IFI, and mold was the most frequent causative organism for late IFI. A prior history of IFI, human leukocyte antigen (HLA) mismatch, long-time neutropenia, and acute graft-versus-host-disease (GVHD) were risk factors for early IFI. A prior history of IFI, corticosteroid therapy, cytomegalovirus (CMV) disease, and chronic GVHD were risk factors for late IFI. IFI-related mortality was 53.26%. The 12-year overall survival (OS) rate for IFI was significantly lower than that of patients without IFI (41.9% vs. 63.6%, P<0.01).
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