CLC number: R562.25
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2018-08-07
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Citations: Bibtex RefMan EndNote GB/T7714
Sheng-tao Zhao, Chang-zheng Wang. Regulatory T cells and asthma[J]. Journal of Zhejiang University Science B, 2018, 19(9): 663-673.
@article{title="Regulatory T cells and asthma",
author="Sheng-tao Zhao, Chang-zheng Wang",
journal="Journal of Zhejiang University Science B",
volume="19",
number="9",
pages="663-673",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700346"
}
%0 Journal Article
%T Regulatory T cells and asthma
%A Sheng-tao Zhao
%A Chang-zheng Wang
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 9
%P 663-673
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700346
TY - JOUR
T1 - Regulatory T cells and asthma
A1 - Sheng-tao Zhao
A1 - Chang-zheng Wang
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 9
SP - 663
EP - 673
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700346
Abstract: asthma is a chronic disease of airway inflammation due to excessive T helper cell type 2 (Th2) response. Present treatment based on inhalation of synthetic glucocorticoids can only control Th2-driven chronic eosinophilic inflammation, but cannot change the immune tolerance of the body to external allergens. regulatory T cells (Tregs) are the main negative regulatory cells of the immune response. Tregs play a great role in regulating allergic, autoimmune, graft-versus-host responses, and other immune responses. In this review, we will discuss the classification and biological characteristics, the established immunomodulatory mechanisms, and the characteristics of induced differentiation of Tregs. We will also discuss the progress of Tregs in the field of asthma. We believe that further studies on the regulatory mechanisms of Tregs will provide better treatments and control strategies for asthma.
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