CLC number: X131
On-line Access: 2018-05-05
Received: 2018-01-18
Revision Accepted: 2018-03-20
Crosschecked: 2018-04-18
Cited: 0
Clicked: 3966
Mei-qing Jin, Dong Zhang, Ying Zhang, Shan-shan Zhou, Xian-ting Lu, Hong-ting Zhao. Neurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane[J]. Journal of Zhejiang University Science B, 2018, 19(5): 400-408.
@article{title="Neurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane",
author="Mei-qing Jin, Dong Zhang, Ying Zhang, Shan-shan Zhou, Xian-ting Lu, Hong-ting Zhao",
journal="Journal of Zhejiang University Science B",
volume="19",
number="5",
pages="400-408",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1800033"
}
%0 Journal Article
%T Neurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane
%A Mei-qing Jin
%A Dong Zhang
%A Ying Zhang
%A Shan-shan Zhou
%A Xian-ting Lu
%A Hong-ting Zhao
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 5
%P 400-408
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1800033
TY - JOUR
T1 - Neurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane
A1 - Mei-qing Jin
A1 - Dong Zhang
A1 - Ying Zhang
A1 - Shan-shan Zhou
A1 - Xian-ting Lu
A1 - Hong-ting Zhao
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 5
SP - 400
EP - 408
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1800033
Abstract: decabromodiphenylethane (DBDPE) has been widely used as an alternative flame retardant due to the restriction or phase-out of traditional polybrominated diphenyl ethers (PBDEs), and is of increasing concern regarding its ubiquity, persistence, and potential adverse effects. In the present study, the toxicological effects of DBDPE were evaluated using zebrafish as an in vivo model. Upon being exposed to DBDPE-polluted sediments for a short term, it was found that the mortality and malformation of zebrafish (including edema, bent notochord, and bent tail) were not affected even at the highest concentration tested (1000.0 µg/kg dry sediment). Regarding behavioral responses, it was found that zebrafish larvae of 48 hours post fertilization (hpf) in all groups escaped successfully with a touch to the dorsal fin. However, when exposed to the highest DBDPE concentration, the larvae of 120 hpf exhibited significantly smaller distances as compared to the control. Moreover, the results of the acetylcholinesterase (AChE) activity, the expression levels of two important nerve-related genes, and the cell apoptosis all indicated that DBDPE posed low neurotoxicity in embryo-larval zebrafish. The results in this study shed some light on the potential risks of DBDPE in the real environment and highlight the application of the sediment exposure route in the future.
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