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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.3 P.197-211


Advances in the study of mitophagy in osteoarthritis

Author(s):  Hong CAO, Xuchang ZHOU, Bowen XU, Han HU, Jianming GUO, Miao WANG, Nan LI, Jun ZOU

Affiliation(s):  Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai 200438, China; more

Corresponding email(s):   junzou@sus.edu.cn, linan@immunol.org

Key Words:  Mitophagy, Osteoarthritis, Chondrocyte, Mitochondria, Apoptosis

Hong CAO, Xuchang ZHOU, Bowen XU, Han HU, Jianming GUO, Miao WANG, Nan LI, Jun ZOU. Advances in the study of mitophagy in osteoarthritis[J]. Journal of Zhejiang University Science B, 2024, 25(3): 197-211.

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author="Hong CAO, Xuchang ZHOU, Bowen XU, Han HU, Jianming GUO, Miao WANG, Nan LI, Jun ZOU",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Advances in the study of mitophagy in osteoarthritis
%A Hong CAO
%A Xuchang ZHOU
%A Bowen XU
%A Han HU
%A Jianming GUO
%A Miao WANG
%A Nan LI
%A Jun ZOU
%J Journal of Zhejiang University SCIENCE B
%V 25
%N 3
%P 197-211
%@ 1673-1581
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300402

T1 - Advances in the study of mitophagy in osteoarthritis
A1 - Hong CAO
A1 - Xuchang ZHOU
A1 - Bowen XU
A1 - Han HU
A1 - Jianming GUO
A1 - Miao WANG
A1 - Nan LI
A1 - Jun ZOU
J0 - Journal of Zhejiang University Science B
VL - 25
IS - 3
SP - 197
EP - 211
%@ 1673-1581
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300402

osteoarthritis (OA), characterized by cartilage degeneration, synovial inflammation, and subchondral bone remodeling, is among the most common musculoskeletal disorders globally in people over 60 years of age. The initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic process. Cartilage degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte metabolism. Therefore, maintaining mitochondrial homeostasis is an important strategy to mitigate OA. mitophagy is a vital process for autophagosomes to target, engulf, and remove damaged and dysfunctional mitochondria, thereby maintaining mitochondrial homeostasis. Cumulative studies have revealed a strong association between mitophagy and OA, suggesting that the regulation of mitophagy may be a novel therapeutic direction for OA. By reviewing the literature on mitophagy and OA published in recent years, this paper elaborates the potential mechanism of mitophagy regulating OA, thus providing a theoretical basis for studies related to mitophagy to develop new treatment options for OA.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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