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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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Magnesium and Gallium co-loaded microspheres accelerate bone repair through osteogenesis and antibiosis
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Jin Bai,Si Shen,Yan Liu,Shendan Xu,Tianqi Li,Zirou Wang,Weili Liu, Lingling Pu,Gang Chen,Xinxing Wang. Magnesium and Gallium co-loaded microspheres accelerate bone repair through osteogenesis and antibiosis[J]. Journal of Zhejiang University Science , , (): .
@article{title="Magnesium and Gallium co-loaded microspheres accelerate bone repair through
osteogenesis and antibiosis",
author="Jin Bai,Si Shen,Yan Liu,Shendan Xu,Tianqi Li,Zirou Wang,Weili Liu, Lingling Pu,Gang Chen,Xinxing Wang",
journal="Journal of Zhejiang University Science ",
volume="",
number="",
pages="",
year="",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-BDMJ-D-23-00253"
}
%0 Journal Article
%T Magnesium and Gallium co-loaded microspheres accelerate bone repair through
osteogenesis and antibiosis
%A Jin Bai
%A Si Shen
%A Yan Liu
%A Shendan Xu
%A Tianqi Li
%A Zirou Wang
%A Weili Liu
%A Lingling Pu
%A Gang Chen
%A Xinxing Wang
%J Journal of Zhejiang University SCIENCE
%V
%N
%P
%@ 1673-1581
%D
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-BDMJ-D-23-00253
TY - JOUR
T1 - Magnesium and Gallium co-loaded microspheres accelerate bone repair through
osteogenesis and antibiosis
A1 - Jin Bai
A1 - Si Shen
A1 - Yan Liu
A1 - Shendan Xu
A1 - Tianqi Li
A1 - Zirou Wang
A1 - Weili Liu
A1 - Lingling Pu
A1 - Gang Chen
A1 - Xinxing Wang
J0 - Journal of Zhejiang University Science
VL -
IS -
SP -
EP -
%@ 1673-1581
Y1 -
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-BDMJ-D-23-00253
Abstract: Bone defects have serious economic and clinical impacts; however, despite improvements in their management, their outcome
s are limited. A variety of biomaterials have been used to treat complex bone defects. However, the final bone repair outcome
might be adversely affected by poor osteogenic capacity and risk of infection. Consequently, therapeutic methods are required
that reduce bacterial contamination and increase the osteogenic properties of biomaterials. Herein, poly (lactic acid-co-glycol
ic acid) (PLGA) microspheres co-loaded with magnesium ions (Mg2+) and gallium ions (Ga3+) (Mg-Ga@PLGA) were prepare
d, which could fill irregular bone defects and display good biosafety. In vitro, Mg-Ga@PLGA not only showed a synergistic e
ffect on promoting osteogenic differentiation but also inhibited osteoclastic differentiation. We found that Mg-Ga@PLGA de
monstrated a superior antibacterial effect. In vivo, Mg-Ga@PLGA exhibited a good osteogenic ability in situ. In conclusion,
Mg-Ga@PLGA has good potential to treat bone defects at risk of infection.
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