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On-line Access: 2019-04-15
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Polycaprolactone–carboxymethyl cellulose composites for manufacturing porous scaffolds by material extrusion
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M. E. Alemán-Domínguez, Z. Ortega, A. N. Benítez, Mario Monzón, L. V. Garzón, Sara Ajami, Chaozong Liu. Polycaprolactone–carboxymethyl cellulose composites for manufacturing porous scaffolds by material extrusion[J]. Journal of Zhejiang University Science D, 2018, 1(4): 245-253.
@article{title="Polycaprolactone–carboxymethyl cellulose composites for manufacturing porous scaffolds by material extrusion",
author="M. E. Alemán-Domínguez, Z. Ortega, A. N. Benítez, Mario Monzón, L. V. Garzón, Sara Ajami, Chaozong Liu",
journal="Journal of Zhejiang University Science D",
volume="1",
number="4",
pages="245-253",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-018-0024-z"
}
%0 Journal Article
%T Polycaprolactone–carboxymethyl cellulose composites for manufacturing porous scaffolds by material extrusion
%A M. E. Alemán-Domínguez
%A Z. Ortega
%A A. N. Benítez
%A Mario Monzón
%A L. V. Garzón
%A Sara Ajami
%A Chaozong Liu
%J Journal of Zhejiang University SCIENCE D
%V 1
%N 4
%P 245-253
%@ 1869-1951
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-018-0024-z
TY - JOUR
T1 - Polycaprolactone–carboxymethyl cellulose composites for manufacturing porous scaffolds by material extrusion
A1 - M. E. Alemán-Domínguez
A1 - Z. Ortega
A1 - A. N. Benítez
A1 - Mario Monzón
A1 - L. V. Garzón
A1 - Sara Ajami
A1 - Chaozong Liu
J0 - Journal of Zhejiang University Science D
VL - 1
IS - 4
SP - 245
EP - 253
%@ 1869-1951
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-018-0024-z
Abstract: Polycaprolactone–carboxymethyl cellulose composites have been obtained and used to print porous structures by material extrusion.Thematerialsusedcontained0,2and5%w/wofthecarboxymethylcelluloseadditive.Thesestructureshavebeen analyzed in terms of their morphology (including the evaluation of their porosity), mechanical properties under compression loadandcellaffinity.Cellaffinityhasbeenevaluatedbyculturingsheepmesenchymalstemcellsandanalyzingtheirviability bytheAlamarBlue® assayatdays1,3,6and8.Theresultsshowthatcompositessampleshavesimilarvaluesofporosityand apparent density than pure polycaprolactone ones. However, samples containing 5% w/w of carboxymethyl cellulose have micropores on the filaments due to a hindered deposition process. This characteristic affects the mechanical properties of the structures,sotheseoneshaveameancompressionmodulussignificantlylowerthanpurepolycaprolactonescaffolds.However, the samples containing 2% w/w of carboxymethyl cellulose show no significant difference with the pure polycaprolactone onesintermsoftheirmechanicalproperties.Moreover,thepresenceof2%w/wofadditiveimprovescellproliferationonthe surface of the porous structures. As complementary information, the flow properties of the composite materials were studied and the power law equations at 210 °C obtained, as this temperature was the 3D printing temperature. These equations can be useful for simulation and designing purposes of other manufacturing processes.
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