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On-line Access: 2025-09-06
Received: 2024-12-07
Revision Accepted: 2025-02-11
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Microporous 3D bioprinting: a novel technology for biofabrication
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Hongxiang Cai (???), Yongrui Cai (???), Zichuan Ding (???), Jiaxuan Fan (???), Yahao Lai (???), Chao Huang (??), Boyi Jiang (???), Can Zhou (??), Zongke Zhou (???), Xingcai Zhang (???) & Zeyu Luo (???) . Microporous 3D bioprinting: a novel technology for biofabrication[J]. Journal of Zhejiang University Science D, 2025, 8(5): 847-876.
@article{title="Microporous 3D bioprinting: a novel technology for biofabrication",
author="Hongxiang Cai (???), Yongrui Cai (???), Zichuan Ding (???), Jiaxuan Fan (???), Yahao Lai (???), Chao Huang (??), Boyi Jiang (???), Can Zhou (??), Zongke Zhou (???), Xingcai Zhang (???) & Zeyu Luo (???) ",
journal="Journal of Zhejiang University Science D",
volume="8",
number="5",
pages="847-876",
year="2025",
publisher="Zhejiang University Press & Springer",
doi="10.1631/bdm.2400490"
}
%0 Journal Article
%T Microporous 3D bioprinting: a novel technology for biofabrication
%A Hongxiang Cai (???)
%A Yongrui Cai (???)
%A Zichuan Ding (???)
%A Jiaxuan Fan (???)
%A Yahao Lai (???)
%A Chao Huang (??)
%A Boyi Jiang (???)
%A Can Zhou (??)
%A Zongke Zhou (???)
%A Xingcai Zhang (???) & Zeyu Luo (???)
%J Journal of Zhejiang University SCIENCE D
%V 8
%N 5
%P 847-876
%@ 1869-1951
%D 2025
%I Zhejiang University Press & Springer
%DOI 10.1631/bdm.2400490
TY - JOUR
T1 - Microporous 3D bioprinting: a novel technology for biofabrication
A1 - Hongxiang Cai (???)
A1 - Yongrui Cai (???)
A1 - Zichuan Ding (???)
A1 - Jiaxuan Fan (???)
A1 - Yahao Lai (???)
A1 - Chao Huang (??)
A1 - Boyi Jiang (???)
A1 - Can Zhou (??)
A1 - Zongke Zhou (???)
A1 - Xingcai Zhang (???) & Zeyu Luo (???)
J0 - Journal of Zhejiang University Science D
VL - 8
IS - 5
SP - 847
EP - 876
%@ 1869-1951
Y1 - 2025
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/bdm.2400490
Abstract: Three-dimensional (3D) bioprinting provides a rapid and efficient method for fabricating customized bioprinted tissues that
replicate the complex architecture of native tissues. However, in 3D bioprinting, the need for dense biomaterial networks to
ensure mechanical strength and structural fidelity often restricts the spreading, migration, and proliferation of encapsulated
cells, as well as the transport of materials. This review summarizes effective strategies for manufacturing microporous bio?
printed tissues via 3D bioprinting. The term microporous refers to interconnected, micrometer-sized pore-like structures
within the internal materials of bioprinted tissues, including the microstructure of a single extruded fiber in extrusion print?
ing. This differs from the macroscopic pore structure formed between fibers composed of print tracks or computer-aided de?
sign presets. These micropores play a crucial role in advancing biomanufacturing and 3D bioprinting by providing space for
cell adhesion and proliferation while facilitating the timely transport of nutrients and metabolic waste essential for cell
growth. Additionally, microporous bioprinted tissues offer the mechanical support needed for cell seeding and serve as sites
for extracellular matrix deposition. As microporous 3D bioprinting continues to advance, it has the potential to address unre?
solved challenges in fields such as organ transplantation, tissue regeneration, and tissue replacement.
Open peer comments: Debate/Discuss/Question/Opinion
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